Long-term stability of epinephrine dispensed in unsealed syringes for the first-aid treatment of anaphylaxis

Annals of Allergy, Asthma and Immunology

Volumn 102, Issue 6, 2009, Pages 500-503

  Rawas Qalaji, Mutasem ^a   Simons, F Estelle R ^b   Collins, David ^b   Simons, Keith J ^b,c  

^a NOVA SOUTHEASTERN UNIVERSITY   (United States)

^b UNIVERSITY OF MANITOBA   (Canada)

^c UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN;

ANAPHYLAXIS; ARTICLE; CONTROLLED STUDY; DARKNESS; DRUG STABILITY; DRUG STORAGE; ENVIRONMENTAL TEMPERATURE; FIRST AID; HIGH TEMPERATURE; HUMIDITY; LIGHT; LOW TEMPERATURE; PRIORITY JOURNAL; SYRINGE;

EID: 67549142348     PISSN: 10811206     EISSN: 15344436     Source Type: Journal    
DOI: 10.1016/S1081-1206(10)60124-X     Document Type: Article

References (10)

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2. Soar J, Pumphrey R, Cant A, et al. Emergency treatment of anaphylactic reactions-guidelines for healthcare providers. Resuscitation. 2008;77:157-169.
3. McLean-Tooke APC, Bethune CA, Fay AC, Spickett GP. Adrenaline in the treatment of anaphylaxis: what is the evidence? BMJ. 2003;327:1332-1335. (Pubitemid 37510459)
4. Simons FER. First-aid treatment of anaphylaxis to food: focus on epinephrine. J Allergy Clin Immunol. 2004;113:837-844. (Pubitemid 38608591)
5. Simons FER. Lack of worldwide availability of epinephrine autoinjectors for outpatients at risk of anaphylaxis. Ann Allergy Asthma Immunol. 2005;94:534-538. (Pubitemid 40712775)
6. Simons FER, for the World Allergy Organization. Epinephrine autoinjectors: first-aid treatment still out of reach for many at risk of anaphylaxis in the community. Ann Allergy Asthma Immunol. In press.
7. Simons FER, Chan ES, Gu X, Simons KJ. Epinephrine for the out-of-hospital (first aid) treatment of anaphylaxis in infants: is the ampule/syringe/needle method practical? J Allergy Clin Immunol. 2001;108:1040-1044. (Pubitemid 33151561)
8. USP/NF. Official Monograph: Epinephrine Injection. 30/25 ed. Rockville, MD: US Pharmacopeial Convention Inc; 2007.
9. Simons FER, Gu X, Simons KJ. Outdated EpiPen and EpiPen Jr autoinjectors: past their prime? J Allergy Clin Immunol. 2000;105:1025-1030.
10. Stepensky D, Chorny M, Dabour Z, Schumacher I. Long-term stability of L-adrenaline injections: kinetics of sulfonation and racemization pathways of drug degradation. J Pharm Sci. 2004;93:969-980. (Pubitemid 38420407)