Application of bipolar electrodialysis to E. coli fermentation for simultaneous acetate removal and pH control

Biotechnology Letters

Volumn 32, Issue 8, 2010, Pages 1053-1057

  Wong, Michael ^a   Woodley, John M ^b   Lye, Gary J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

Acetate removal; Bipolar electrodialysis; E. coli TG1; pH control

Indexed keywords

ACETATE REMOVAL; ANION EXCHANGE; BASE ADDITION; BIPOLAR ELECTRODIALYSIS; BIPOLAR MEMBRANES; CATION EXCHANGES; CELL PAIRS; E. COLI; FED BATCHES; IN-SITU; PH CONTROL; RECOMBINANT PROTEIN; SIMULTANEOUS REMOVAL; STIRRED TANK BIOREACTORS;

ESCHERICHIA COLI; FERMENTATION; PREDICTIVE CONTROL SYSTEMS;

ELECTRODIALYSIS;

ACETIC ACID DERIVATIVE; AMMONIA; CULTURE MEDIUM;

ARTICLE; BIOREACTOR; CHEMISTRY; CULTURE MEDIUM; DIALYSIS; ESCHERICHIA COLI; FERMENTATION; METABOLISM; METHODOLOGY; PH; PROCEDURES; TOXICITY;

ACETATES; AMMONIA; BIOREACTORS; CULTURE MEDIA; DIALYSIS; ESCHERICHIA COLI; FERMENTATION; HYDROGEN-ION CONCENTRATION;

ESCHERICHIA COLI;

EID: 77954536561     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1007/s10529-010-0266-0     Document Type: Article

References (10)

1. Akesson M, Hagander P, Axelsson JP (2000) Avoiding acetate accumulation in Escherichia coli cultures using feedback control of glucose feeding. Biotechnol Bioeng 73: 223-230.
2. Eiteman M, Altman E (2006) Overcoming acetate in Escherichia coli recombinant protein fermentations. Trends Biotechnol 24: 530-536.
3. Grib H, Bonnal L, Sandeaux J, Sandeaux R, Gavach C, Mameri N (1998) Extraction of amphoteric amino acids by an electromembrane process. pH and electrical state control by electrodialysis with bipolar membranes. J Chem Technol Biotechnol 73: 64-70.
4. Han K, Lim H, Hong J (1992) Acetic acid formation in Escherichia coli fermentation. Biotechnol Bioeng 39: 663-671.
5. Huang C, Xu T, Zhang Y, Xue T, Chen G (2007) Application of electrodialysis to the production of organic acids: state-of-the-art and recent developments. J Membr Sci 288: 1-12.
6. Jaime-Ferrer JS, Couallier E, Viers Ph, Durand G, Rakib M (2008) Three-compartment bipolar membrane electrodialysis for splitting of sodium formate into formic acid and sodium hydroxide: role of diffusion of molecular acid. J Membr Sci 325: 528-536.
7. Korz DJ, Rinas U, Hellmuth K, Sanders EA, Deckwer WD (1995) Simple fed-batch technique for high cell density cultivation of Escherichia coli. J Biotechnol 39: 59-65.
8. Koter S, Warszawski A (2000) Electromembrane processes in environment protection. Pol J Environ Stud 9: 45-56.
9. Muller T, Walter B, Wirtz A, Burkovski A (2006) Ammonium toxicity in bacteria. Curr Microbiol 52: 400-406.
10. Wong M, Wright M, Woodley JM, Lye GJ (2009) Enhanced recombinant protein expression in batch and fed-batch Escherichia coli fermentation based on removal of inhibitory acetate by electrodialysis. J Chem Technol Biotechnol 84: 1284-1291.