Crystal structure and functional characterization of an immunomodulatory salivary cystatin from the soft tick Ornithodoros moubata

Biochemical Journal

Volumn 429, Issue 1, 2010, Pages 103-112

  Salát, Jiří ^a,b   Paesen, Guido C ^c   Řezáčová, Pavlína ^d,e   Kotsyfakis, Michalis ^a,f   Kovářová, Zuzana ^d,g   Šanda, Miloslav ^d   Majtán, Juraj ^c   Grunclová, Lenka ^a,b   Horká, Helena ^a,b   Andersen, John F ^f   Brynda, Jiří ^d,e   Horn, Martin ^d   Nunn, Miles A ^c   Kopáček, Petr ^a,b   Kopecký, Jan ^a,b   Mareš, Michael ^d  

^a INSTITUTE OF PARASITOLOGY   (Czech Republic)

^b UNIVERSITY OF SOUTH BOHEMIA   (Czech Republic)

^c CENTRE FOR ECOLOGY AND HYDROLOGY   (United Kingdom)

^d INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^e INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^f NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^g CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Cathepsin; Cystatin; Ornithodoros moubata; Parasite; Peptidase inhibitor

Indexed keywords

ADAPTIVE IMMUNE RESPONSE; AFRICAN SWINE FEVER VIRUS; BIOLOGICAL CHARACTERIZATION; BIOLOGICAL IMPACTS; BORRELIA; CYSTATINS; DENDRITIC CELLS; DISEASE VECTORS; FUNCTIONAL CHARACTERIZATION; IN-VITRO; INFLAMMATORY CYTOKINES; INHIBITORY ACTIVITY; INTERLEUKIN-12; NECROSIS FACTORS; PARASITE-; PEPTIDASE INHIBITORS; PROTEOMIC ANALYSIS; T CELLS;

ANTIGENS; BODY FLUIDS; DENDRIMERS; VIRUSES;

CRYSTAL STRUCTURE;

CATHEPSIN L; CATHEPSIN S; CYSTATIN; CYSTATIN OMC2; EXOPEPTIDASE; INTERLEUKIN 12; PROTEINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYSTATIN S; IMMUNOLOGIC FACTOR;

ADAPTIVE IMMUNITY; ARTICLE; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DENDRITIC CELL; DISEASE CARRIER; ENZYME STRUCTURE; FEMALE; IMMUNOMODULATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ORNITHODOROS MOUBATA; PRIORITY JOURNAL; PROTEIN ANALYSIS; SALIVA ANALYSIS; STRUCTURE ACTIVITY RELATION; TICK; AMINO ACID SEQUENCE; ANIMAL; C3H MOUSE; C57BL MOUSE; CHEMISTRY; COMPARATIVE STUDY; CRYSTALLIZATION; IMMUNOLOGY; MOLECULAR GENETICS; PHYSIOLOGY; TRANSGENIC MOUSE; X RAY CRYSTALLOGRAPHY;

AFRICAN SWINE FEVER VIRUS; ARGASIDAE; BORRELIA DUTTONII; IXODIDA; MUS; ORNITHODOROS MOUBATA; SPIROCHAETA;

AMINO ACID SEQUENCE; ANIMALS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; FEMALE; IMMUNOLOGIC FACTORS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; ORNITHODOROS; SALIVARY CYSTATINS;

EID: 77954523062     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20100280     Document Type: Article

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