Antedrug budesonide by intrapulmonary treatment attenuates bleomycin-induced lung injury in rats with minimal systemic adverse effects

Biological and Pharmaceutical Bulletin

Volumn 33, Issue 7, 2010, Pages 1206-1211

  Kohno, Masayuki ^a   Haramoto, Mari ^a   Nakajima, Oumi ^a   Yang, Liying ^a   Hinotsu, Shiro ^a   Yokohira, Masanao ^a   Imaida, Katsumi ^b   Kawakami, Koji ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KAGAWA UNIVERSITY   (Japan)

Author keywords

Antedrug; Corticosteroid; Drug delivery; Intrapulmonary treatment

Indexed keywords

BLEOMYCIN; BUDESONIDE; COLLAGEN; DEXAMETHASONE; PROTEIN;

ADVERSE OUTCOME; AEROSOL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BODY WEIGHT; CELL COUNT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DOSAGE FORM COMPARISON; DRUG EFFECT; DRUG HALF LIFE; DRUG TISSUE LEVEL; FEMALE; HISTOPATHOLOGY; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATORY CELL; LUNG FIBROSIS; LUNG INJURY; LUNG LAVAGE; NONHUMAN; RAT; RISK BENEFIT ANALYSIS; SPLEEN WEIGHT; TREATMENT DURATION;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; AREA UNDER CURVE; BLEOMYCIN; BRONCHOALVEOLAR LAVAGE FLUID; BUDESONIDE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEXAMETHASONE; HALF-LIFE; LUNG; ORGAN SIZE; RATS;

EID: 77954511345     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.33.1206     Document Type: Article

References (30)

1. Katzenstein A. L. A., Myers J. L., Am. J. Respir. Crit. Care Med., 157, 1301-1315 (1998).
2. Luppi F., Cerri S., Beghe B., Fabbri L. M., Richeldi L., Respir. Med., 98, 1035-1044 (2004).
3. du Bois R. M., Nat. Rev. Drug Discov., 9, 129-140 (2010).
4. Flaherty K. R., Toews G. B., Lynch J. P. 3rd, Kazerooni E. A., Am. J. Med., 110, 278-282 (2001).
5. Lee H. J., Soliman M. R., Science, 215, 989-991 (1982).
6. Mygind N., Andersson M., Acta Otolaryngol., 126, 1022-1029 (2006).
7. Cerasoli F. Jr., Chest, 130, 54S-64S (2006).
8. Campieri M., Ferguson A., Doe W., Persson T., Nilsson L. G., Gut, 41, 209-214 (1997).
9. Yokohira M., Takeuchi H., Yamakawa K., Saoo K., Matsuda Y., Zeng Y., Hosokawa Y., Imaida K., Exp. Toxicol. Pathol., 58, 211-221 (2007).
10. Yokohira M., Kuno T., Yamakawa K., Hashimoto N., Ninomiya F., Suzuki S., Saoo K., Imaida K., J. Toxicol. Pathol., 22, 1-10 (2009).
11. Yao H. W., Zhu J. P., Zhao M. H., Lu Y., Respiration, 73, 236-242 (2006).
12. Iglesias Y., Fente C. A., Vázquez B., Franco C., Cepeda A., Mayo S., Gigosos P. G., J. Agric. Food Chem., 47, 4275-4279 (1999).
13. Chanoine F., Grenot C., Heidmann P., Junien J. L., Drug Metab. Dispos., 19, 546-553 (1991).
14. Gong L. K., Li X. H., Wang H., Zhang L., Chen F. P., Cai Y., Qi X. M., Liu L. L., Liu Y. Z., Wu X. F., Huang C. G., Ren J., J. Ethnopharmacol., 96, 537-544 (2005).
15. Günther A., Lübke N., Ermert M., Schermuly R. T., Weissmann N., Breithecker A., Markart P., Ruppert C., Quanz K., Ermert L., Grimminger F., Seeger W., Am. J. Respir. Crit. Care Med., 168, 1358-1365 (2003).
16. Huaux F., Liu T., McGarry B., Ullenbruch M., Phan S. H., J. Immunol., 170, 2083-2092 (2003).
17. Walter N., Collard H. R., King T. E. Jr., Proc. Am. Thorac. Soc., 3, 330-338 (2006).
18. Barnes P. J., Stockley R. A., Eur. Respir. J., 25, 1084-1106 (2005).
19. Labiris N. R., Dolovich M. B., Br. J. Clin. Pharmacol., 56, 600-612 (2003).
20. Laube B. L., Geller D. E., Lin T. C., Dalby R. N., Diener-West M., Zeitlin P. L., Respir. Care, 50, 1438-1444 (2005).
21. Newman S., Salmon A., Nave R., Drollmann A., Respir. Med., 100, 375-384 (2006).
22. Usmani O. S., Biddiscombe M. F., Barnes P. J., Am. J. Respir. Crit. Care Med., 172, 1497-1504 (2005).
23. Chen Z., Vaughn D. A., Blakely P., Fanestil D. D., J. Am. Soc. Nephrol., 5, 1361-1368 (1994).
24. Keil D. E., Luebke R. W., Pruett S. B., Int. J. Immunopharmacol., 17, 157-166 (1995).
25. Miller-Larsson A., Jansson P., Runström A., Brattsand R., Am. J. Respir. Crit. Care Med., 162, 1455-1461 (2000).
26. Samtani M. N., Jusko W. J., Biopharm. Drug Dispos., 26, 85-91 (2005).
27. Labiris N. R., Dolovich M. B., Br. J. Clin. Pharmacol., 56, 588-599 (2003).
28. Fichtner-Feigl S., Strober W., Kawakami K., Puri R. K., Kitani A., Nat. Med., 12, 99-106 (2006).
29. Ask K., Martin G. E., Kolb M., Gauldie J., Proc. Am. Thorac. Soc., 3, 389-393 (2006).
30. Moeller A., Ask K., Warburton D., Gauldie J., Kolb M., Int. J. Biochem. Cell Biol., 40, 362-382 (2008).