Neuropathic pain and neuron-glia interactions in the spinal cord

Journal of Anesthesia

Volumn 24, Issue 2, 2010, Pages 325-327

  Kohno, Tatsuro ^a,b  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b Pain Mechanism Research Group   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GLUTAMATE DECARBOXYLASE; PURINERGIC P2X4 RECEPTOR;

ALLODYNIA; CONFERENCE PAPER; GATE CONTROL THEORY; HYPERALGESIA; MECHANICAL STIMULATION; MICROGLIA; NERVE CELL EXCITABILITY; NEUROPATHIC PAIN; NOCICEPTION; PERIPHERAL NERVE INJURY; SIGNAL TRANSDUCTION; SPINAL CORD; SPINAL CORD NERVE CELL; SYNAPTIC TRANSMISSION; THERMAL STIMULATION;

ANIMALS; CHRONIC DISEASE; HUMANS; MICROGLIA; NEURALGIA; PERIPHERAL NERVOUS SYSTEM DISEASES; RECEPTORS, PURINERGIC P2; SIGNAL TRANSDUCTION; SPINAL CORD;

EID: 77954509951     PISSN: 09138668     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00540-010-0918-1     Document Type: Conference Paper

References (16)

1. McCleskey EW. New player in pain. Nature. 2003;424:729-730
2. Melzack R, Wall PD. Pain mechanisms: a new theory. Science. 1965;150:971-979
3. Woolf CJ, Salter MW. Neuronal plasticity: increasing the gain in pain. Science. 2000;288:1765-1769
4. Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain. 1988;33:87-107.
5. Decosterd I, Woolf CJ. Spared nerve injury: an animal model of persistent peripheral neuropathic pain. Pain. 2000;87:149-158
6. Kohno T, Moore KA, Baba H, Woolf CJ. Peripheral nerve injury alters excitatory synaptic transmission in lamina II of the rat dorsal horn. J Physiol. 2003;548:131-138
7. Moore KA, Kohno T, Karchewski LA, Scholz J, Baba H, Woolf CJ. Partial peripheral nerve injury promotes a selective loss of GABAergic inhibition in the superficial dorsal horn of the spinal cord. J Neurosci. 2002;22:6724-6731
8. Watkins LR, Milligan ED, Maier SF. Glial activation: a driving force for pathological pain. Trends Neurosci. 2001;24:450-455
9. Tsuda M, Inoue K, Salter MW. Neuropathic pain and spinal microglia: a big problem from molecules in "small" glia. Trends Neurosci. 2005;28:101-107
10. Inoue K, Tsuda M. Microglia and neuropathic pain. Glia. 2009;57:1469-1479
11. Tsuda M, Shigemoto-Mogami Y, Koizumi S, Mizokoshi A, Kohsaka S, Salter MW, Inoue K. P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature. 2003;424:778-783
12. Coull JA, Beggs S, Boudreau D, Boivin D, Tsuda M, Inoue K, Gravel C, Salter MW, De Koninck Y. BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature. 2005;438:1017-1021
13. Torsney C, MacDermott AB. Neuroscience: a painful factor. Nature. 2005;438:923-925
14. Coull JA, Boudreau D, Bachand K, Prescott SA, Nault F, Sik A, De Koninck P, De Koninck Y. Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain. Nature. 2003;424:938-942
15. Ji RR, Kawasaki Y, Zhuang ZY, Wen YR, Decosterd I. Possible role of spinal astrocytes in maintaining chronic pain sensitization: review of current evidence with focus on bFGF/JNK pathway. Neuron Glia Biol. 2006;2:259-269
16. Kawasaki Y, Xu ZZ, Wang X, Park JY, Zhuang ZY, Tan PH, Gao YJ, Roy K, Corfas G, Lo EH, Ji RR. Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain. Nat Med. 2008;14:331-336