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Rapid Communications in Mass Spectrometry

Volumn 24, Issue 14, 2010, Pages 2151-2161

The use of 18O-exchange and base-catalyzed n-dealkylation with liquid chromatography/tandem mass spectrometry to identify carbinolamide metabolites

(5) Bessire, Andrew J a Vaz, Alfin D N a Walker, Gregory S a Wang, Wei Wei a Sharma, Raman a

a PFIZER GLOBAL RESEARCH AND DEVELOPMENT (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMOLECULES; CATALYSIS; CHROMATOGRAPHIC ANALYSIS; DRUG PRODUCTS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE; PHYSIOLOGY; WATER TREATMENT;

ALPHA CARBON; BASE CATALYZED; CARBON ATOMS; COMPOUND SELECTION; DRUG DISCOVERY; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; N-DEALKYLATION; STRUCTURAL ASSIGNMENTS; STRUCTURAL ELUCIDATION;

METABOLITES;

5 ((4' TRIFLUOROMETHYL BIPHENYL 2 CARBONYL) AMINO) 1H INDOLE 2 CARBOXYLIC ACID BENZYLMETHYL CARBAMOYLAMIDE; 5-((4'-TRIFLUOROMETHYL-BIPHENYL-2-CARBONYL)-AMINO)-1H-INDOLE-2-CARBOXYLIC ACID BENZYLMETHYL CARBAMOYLAMIDE; CARBAMIC ACID DERIVATIVE; INDOLE DERIVATIVE; OXYGEN;

ANIMAL; ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; DEALKYLATION; EVALUATION; FEMALE; LIQUID CHROMATOGRAPHY; MALE; METABOLISM; METHODOLOGY; RAT; SPRAGUE DAWLEY RAT; TANDEM MASS SPECTROMETRY;

ANIMALS; CARBAMATES; CATALYSIS; CHROMATOGRAPHY, LIQUID; DEALKYLATION; FEMALE; INDOLES; MALE; MOLECULAR STRUCTURE; OXYGEN ISOTOPES; RATS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY;

EID: 77954483755 PISSN: 09514198 EISSN: 10970231 Source Type: Journal
DOI: 10.1002/rcm.4595 Document Type: Article

Times cited : (2)

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