Effects and mechanism of Weinaokang on reperfusion-induced vascular injury to cerebral microvessels after global cerebral ischemia

Chinese Journal of Integrative Medicine

Volumn 16, Issue 2, 2010, Pages 145-150

  Zheng, Yong Qiu ^a   Liu, Jian Xun ^a   Li, Xin Zhi ^a   Xu, Li ^a  

^a XIYUAN HOSPITAL   (China)

Author keywords

Cerebral ischemia reperfusion; Extracellular signal regulated kinase1 2; G protein coupled receptor kinase; Microvascular endothelial cell; Nitric oxide synthase

Indexed keywords

CHINESE DRUG; CROCIN; G PROTEIN COUPLED RECEPTOR KINASE 2; GELATINASE B; MITOGEN ACTIVATED PROTEIN KINASE 1; NITRIC OXIDE SYNTHASE; UNCLASSIFIED DRUG; WEINAOKANG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY OCCLUSION; ARTICLE; BLOOD VESSEL INJURY; BRAIN BLOOD VESSEL; BRAIN EDEMA; BRAIN ISCHEMIA; C57BL 6 MOUSE; CELL DAMAGE; CELL MEMBRANE; CELL STRUCTURE; COMMON CAROTID ARTERY; CONTROLLED STUDY; CYTOSOL; DRUG EFFECT; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; MALE; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REPERFUSION INJURY; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

ANIMALS; BRAIN ISCHEMIA; CEREBRAL CORTEX; DRUG EVALUATION, PRECLINICAL; DRUGS, CHINESE HERBAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; G-PROTEIN-COUPLED RECEPTOR KINASE 2; MALE; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; MICROVESSELS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHORYLATION; REPERFUSION INJURY; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION;

EID: 77954467053     PISSN: 16720415     EISSN: 19930402     Source Type: Journal    
DOI: 10.1007/s11655-010-0145-5     Document Type: Article

References (22)

1. Fagan SC, Hess DC, Hohnadel EJ, Pollock DM, Ergul A. Targets for vascular protection after acute ischemic stroke. Stroke 2004; 35: 2220-2225.
2. Gursoy-Ozdemir Y, Can A, Dalkara T. Reperfusion-induced oxidative/nitrative injury to neurovascular unit after focal cerebral ischemia. Stroke 2004; 35: 1449-1453.
3. Maier CM, Hsieh L, Crandall T, Narasimhan P, Chan PH. Evaluating therapeutic targets for reperfusion-related brain hemorrhage. Ann Neurol 2006; 59: 929-938.
4. He SY, Qian ZY, Tang FT, Wen N, Xu GL, Sheng L. Effect of Crocin on experimental atherosclerosis in quails and its mechanisms. Life Sci 2005; 77: 907-921.
5. Sugiura M, Shoyama Y, Saito H, Abe K. Crocin (crocetin digentiobiose ester) prevents the inhibitory effect of ethanol on long-term potentiation in the dentate gyrus in vivo. J Pharmacol Exp Ther 1994; 271: 703-707. (Pubitemid 24377753)
6. Zhang Y, Shoyama Y, Sugiura M, Saito H. Effects of Crocus sativus L. on the ethanol-induced impairment of passive avoidance performances in mice. Biol Pharm Bull 1994;17:217-221. (Pubitemid 24112339)
7. Mdzinarishvili A, Kiewert C, Kumar V, Hillert M, Klein J. Bilobalide prevents ischemia-induced edema formation in vitro and in vivo. Neuroscience 2007; 144: 217-222.
8. Zhang G, Liu A, Zhou Y, San X, Jin T, Jin Y. Panax ginseng ginsenoside-Rg2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia. J Ethnopharmacol 2008; 115: 441-448.
9. Huang Y, McNamara JO. Ischemic stroke: "acidotoxicity" is a perpetrator. Cell 2004; 118 : 665-666.
10. Shah ZA, Gilani RA, Sharma P, Vohora SB. Cerebroprotective effect of Korean ginseng tea against global and focal models of ischemia in rats. J Ethnopharmacol 2005; 101: 299-307.
11. Zheng YQ, Liu JX, Wang JN, Xu L. Effects of Crocin on reperfusion-induced oxidative/nitrative injury to cerebral microvessels after global cerebral ischemia. Brain Res 2007;1138:86-94.
12. Preston E, Webster J. Differential passage of [14C]sucrose and [3H]inulin across rat blood-brain barrier after cerebral ischemia. Acta Neuropathol (Berl) 2002; 103: 237-242.
13. Gursoy-Ozdemir Y, Bolay H, Saribas O, Dalkara T. Role of endothelial nitric oxide generation and peroxynitrite formation in reperfusion injury after focal cerebral ischemia. Stroke 2000; 31: 1974-1980.
14. Mark KS, Burroughs AR, Brown RC, Huber JD, Davis TP. Nitric oxide mediates hypoxia-induced changes in paracellular permeability of cerebral microvasculature. Am J Physiol Heart Circ Physiol 2004; 286: H174-180.
15. Harris CA, Chuang TT, Scorer CA. Expression of GRK2 is increased in the left ventricles of cardiomyopathic hamsters. Basic Res Cardiol 2001 ; 96: 364-368.
16. Hata JA, Williams ML, Schroder JN, Lima B, Keys JR, Blaxall BC, et al. Lymphocyte levels of GRK2 (betaARK1) mirror changes in the LVAD-supported failing human heart: lower GRK2 associated with improved beta-adrenergic signaling after mechanical unloading. J Card Fail 2006;12: 360-368.
17. Liu S, Premont RT, Kontos CD, Zhu S, Rockey DC. A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension. Nat Med 2005;11: 952-958. (Pubitemid 41294440)
18. Imura T, Shimohama S, Sato M, Nishikawa H, Madono K, Akaike A, et al. Differential expression of small heat shock proteins in reactive astrocytes after focal ischemia: possible role of beta-adrenergic receptor. J Neurosci 1999;19: 9768-9779. (Pubitemid 30226650)
19. Fardoun RZ, Asghar M, Lokhandwala M. Role of oxidative stress in defective renal dopamine D1 receptor-G protein coupling and function in old Fischer 344 rats. Am J Physiol Renal Physiol 2006;291: F945-951.
20. Mak JC, Hisada T, Salmon M, Barnes PJ, Chung KF. Glucocorticoids reverse IL-1 beta-induced impairment of beta-adrenoceptor-mediated relaxation and up-regulation of G-protein-coupled receptor kinases. Br J Pharmacol 2002;135: 987-996. (Pubitemid 34214458)
21. Cobelens PM, Kavelaars A, Heijnen CJ, Ribas C, Mayor F, Penela P. Hydrogen peroxide impairs GRK2 translation via a calpain-dependent and cdk1-mediated pathway. Cell Signal 2007;19:269-277
22. Hagen SA, Kondyra AL, Grocott HP, El-Moalem H, Bainbridge D, Mathew JP, et al. Cardiopulmonary bypass decreases G protein-coupled receptor kinase activity and expression in human peripheral blood mononuclear cells. Anesthesiology 2003;98: 343-348.