A systems biology approach to radiation therapy optimization

Radiation and Environmental Biophysics

Volumn 49, Issue 2, 2010, Pages 111-124

  Brahme, Anders ^a   Lind, Bengt K ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL APPROACH; CELLULAR DAMAGE; DAMAGE REPAIR; FUNCTIONAL GENOMICS; IN-VIVO; INTENSITY-MODULATED RADIATION THERAPY; LIGHT IONS; LIMITED SPACE; MOLECULAR RADIATION; MOLECULAR RESPONSE; NEW APPROACHES; NORMAL TISSUE; ORGANS AT RISKS; RADIATION RESISTANT; RADIATION THERAPY; RADIATION THERAPY OPTIMIZATION; SUB-CELLULAR; SYSTEMS BIOLOGY; TREATMENT OPTIMIZATION; TUMOR DEVELOPMENT; VASCULAR SYSTEM;

HIGH ENERGY PHYSICS; HISTOLOGY; IONIZING RADIATION; LIGHT; OPTIMIZATION; RADIOTHERAPY; TUMORS;

PHYSICAL THERAPY;

ANIMAL; CELL SURVIVAL; GENE SILENCING; GENETICS; HUMAN; METHODOLOGY; NEOPLASM; PATHOLOGY; RADIATION DOSE; RADIATION EXPOSURE; RADIOTHERAPY; REVIEW; SYSTEMS BIOLOGY;

ANIMALS; CELL SURVIVAL; GENE SILENCING; HUMANS; NEOPLASMS; RADIOTHERAPY; RADIOTHERAPY DOSAGE; SYSTEMS BIOLOGY;

EID: 77954458317     PISSN: 0301634X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00411-010-0268-2     Document Type: Review

References (37)

1. Adamus-Górka M, Mavroidis P, Brahme A, Lind BK (2008) The dose-response relation for rat spinal cord paralysis analyzed in terms of the effective size of the functional subunit. Phys Med Biol 53:6533-6547
2. Amundson SA, Bittner M, Fornace Jr AJ (2003) Functional genomics as a window on radiation stress signaling. Oncogene 22:5828-5833
3. Brahme A (1999) Optimized radiation therapy based on radiobiological objectives. Sem Oncol 9:35-47
4. Brahme A (2000) Development of radiation therapy optimization. Acta Oncol 39:579-595
5. Brahme A (2003a) Biologically optimized 3-dimensional in vivo predictive assay based radiation therapy using positron emission tomography-computerized tomography imaging. Acta Oncol 42:123-136
6. Brahme A (2003b) Fractionation & biologically optimized imrt using in vivo predictive assay based radiation therapy (bioart). Acta Oncol 42:123-136
7. Brahme A (2004) Recent advances in light ion radiation therapy. Int J Rad Onc Biol Phys 58:603-616
8. Brahme A, Rydberg B, Blomquist P (1997) Dual spatially correlated nucleosomal double strand breaks in cell inactivation. In: Microdosimetry: an interdisciplinary approach. The Royal Society of Chemistry, Philadelphia, pp 125-128
9. Curtis SB (1986) Lethal and potential lethal lesions induced by irradiation: a unified repair model. Radiat Res 106:252-270
10. Fei P, El-Deiry W (2003) P53 and radiation response. Oncogene 22:5774-5783
11. Guerrero M, Allen Li X (2004) Extending the linear-quadratic model for large fraction doses pertinent to stereotactic radiotherapy. Phys Med Biol 49:4825-4835
12. Hanahan D, Weinberg R (2000) The hallmarks of cancer. Cell 100:57-70
13. Hirokawa N, Takemura R (2005) Molecular motors and mechanisms of directional transport in neurons. Nature Rev 6:201-214
14. Hoeijmakers JHJ (2001) Genome maintenace mechanisms for preventing cancer. Nature 411:366-374
15. Huang L, Snyder AR, Morgan WF (2003) Radiation-induced genomic instability and its implications for radiation carcinogenesis. Oncogene 22:5848-5854
16. Ishikawa H, Tsuji H, Kamada T, Yanagi T, Mizoe J, Kanai T, Morita S, Wakatsuki M, Shimazaki J, Tsujii H (2006) Carbon ion radiation therapy for prostate cancer: results of a prospective phase ii study. Radiother Oncol 81:57-64
17. Kappos W, Pohlit W (1972) A cybernetic model for radiation reactions in living cells. Int J Radiat Biol 22:51-65
18. Källman P, Ågren AK, Brahme A (1992) Tumour and normal tissue responses to fractionated non-uniform dose delivery. Int J Radiat Biol 62:249-262
19. Lind BK, Brahme A (2007) The radiation response of heterogeneous tumors. Phys Med 23:91-99
20. Lind BK, Persson LM, Edgren MR, Hedlöf I, Brahme A (2003) Repairable conditionally repairable damage model based on dual poisson processes. Radiat Res 160:366-375
21. Lindborg L, Brahme A (1990) Influence of microdosimetric quantities on observed dose-response relationships in radiation therapy. Radiat Res 124:S23-S28
22. Marples B, Wouters BG, Collis SJ, Chalmers AJ, C JM (2004) Lowdose hyper-radiosensitivity: a consequence of ineffective cell cycle arrest of radiation-damaged g2-phas cells. Radiat Res 161:247-255
23. Michalik V, Frankenberg D (1994) Simple and complex doublestrand breaks induced by electrons. Adv Space Res 14:235-248
24. Nakamura Y (2004) Isolation of p53-target genes and their functional analysis. Cancer Sci 95:7-11 (Pubitemid 38208400)
25. Park C, Papiem L, Zhang S, Story M, Timmerman R (2008) Computation of cell survival in heavy ion beams for therapy. Int J Rad Onc Biol Phys 70:847-852
26. Scholz M, Kellerer A, Kraft-Weyrater W, Kraft G (1997) Computation of cell survival in heavy ion beams for therapy. Radiat Environ Biophys 36:59-66
27. Svensson H, Ringborg U, Näslund I, Brahme A (2004) Development of light ion therapy at the karolinska hospital and institute. Radiother Oncol 74:206-210
28. Tachibana A (2004) Genetic and physiological regulation of nonhomologous end-joining in mammalian cells. Adv Biophys 38:21-44
29. Takakura K, Takahashi M, Aoki M, Furusawa Y (2004) Mechanism of apoptosis induction in cultured cells irradiated with high let heavy-ion radiation. In: Yearly Report by NIRS pp 107-108 NIRS, Tokyo
30. Tilikidis A, Brahme A (1994) Microdosimetric description of beam quality and biological effectiveness in radiation therapy. Acta Oncol 33:457-469
31. Tobias CA (1985) The repair-misrepair model in radiobiology. Radiat Res 104:77-95
32. Ward JF (1984) The complexity of DNA damage: relevance to biological consequences. Int J Radiat Biol 66:427-432
33. Wouters BG, Brown JM (1997) Cells at intermediate oxygen levels can be more important than the "hypoxic fraction" in determining tumor response to fractionated radiotherapy. Radiat Res 147:541-550
34. Xu B, Kim ST, Lim DS, Kastan MB (2002) Two molecularly distinct g2/m checkpoints are induced by ionizing irradiation. Mol and Cell Biol 22:247-255
35. Zelefsky M, Chan H, Hunt M, Yamada Y, Shippy AHA (2006) Longterm outcome of high dose intensity modulated radiation therapy for patients with clinically localized prostate. cancer J Urol 176:1415-1419
36. Ågren AK, Brahme A, Thuresson I (1990) Optimization of uncomplicated control for head and neck tumors. Int J Rad Onc Biol Phys 19:1077-1085
37. Ågren Cronqvist AK, Källman P, Turesson I, Brahme A (1995) Voume and heterogeneity dependence of the dose-response relationship for head and neck tumours. Acta Oncol 34:851-860