The radiation response of heterogeneous tumors

Physica Medica

Volumn 23, Issue 3-4, 2007, Pages 91-99

  Lind, Bengt K ^a   Brahme, Anders ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Effective radiation resistance; Heterogeneous tumors; Hypoxic tumors

Indexed keywords

ARTICLE; CANCER RADIOTHERAPY; CANCER SURVIVAL; CELL COMPARTMENTALIZATION; CELL SURVIVAL; CLONOGENESIS; COMPUTER ASSISTED TOMOGRAPHY; DATA ANALYSIS; DOSE RESPONSE; IN VIVO STUDY; POSITRON EMISSION TOMOGRAPHY; PREDICTION; RADIATION DOSE; RADIOSENSITIVITY; TREATMENT RESPONSE;

ANIMALS; CELL HYPOXIA; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, RADIATION; MICE; MODELS, BIOLOGICAL; NEOPLASMS; POSITRON-EMISSION TOMOGRAPHY; RADIATION TOLERANCE; TOMOGRAPHY, X-RAY COMPUTED;

EID: 36448967770     PISSN: 11201797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejmp.2007.08.001     Document Type: Article

References (27)

1. Townsend D.W., and Cherry S.R. Combining anatomy and function: the path to true image fusion. Eur Radiol 11 (2001) 1968-1974
2. Brahme A. Biologically optimized 3-dimensional in vivo predictive assay-based radiation therapy using positron emission tomography-computerized tomography imaging. Acta Oncol 42 (2003) 123-136
3. Porter E.H. The statistics of dose/cure relationships for irradiated tumors. Br J Radiol 53 (1980) 210-227 336-345. Parts I and II
4. Källman P., Ågren A., and Brahme A. Tumour and normal tissue responses to fractionated non-uniform dose delivery. Int J Radiat Biol 62 (1992) 249-262
5. Nilsson J., Lind B.K., and Brahme A. The radiation response of hypoxic and generally heterogeneous tissues. Int J Radiat Biol 78 (2002) 389-405
6. Powers W.E., and Tolmach L.J. A multicomponent X-ray survival curve for mouse lymphosarcoma cells irradiated in vivo. Nature 197 (1963) 710-711
7. Gray L.H. Radiobiologic basis of oxygen as a modifying factor in radiation therapy. Am J Roentgenol Radium Ther Nucl Med 85 (1961) 803-815
8. Henk J.M., and Fowler J.F. Physical and biological basis of radiotherapy of head and neck cancer. In: Hinchcliffe R., and Harrison D. (Eds). Scientific foundations of otolaryngology (1976), William Heinemann Medical Books LTD 733-749
9. Epp E.R., Weiss H., and Santomasso A. The oxygen effect in bacterial cells irradiated with high-intensity pulsed electrons. Radiat Res 34 (1968) 320-325
10. Moulder J.E., and Rockwell S. Hypoxic fractions of solid tumors: experimental techniques, methods of analysis, and a survey of existing data. Int J Radiat Oncol Biol Phys 10 (1984) 695-712
11. Buffa F.M., West C., Byrne K., Moore J.V., and Nahum A.E. Radiation response and cure rate of human colon adenocarcinoma spheroids of different size: the significance of hypoxia on tumor control modeling. Int J Radiat Oncol Biol Phys 49 (2001) 1109-1118
12. Wouters B.G., and Brown J.M. Cells at intermediate oxygen levels can be more important than the "hypoxic fraction" in determining tumor response to fractionated radiotherapy. Radiat Res 147 (1997) 541-550
13. Evans S.M., and Koch C.J. Prognostic significance of tumor oxygenation in humans. Cancer Lett 195 (2003) 1-16
14. Brahme A. Dosimetric precision requirements in radiation therapy. Acta Radiol Oncol 23 (1984) 379-391
15. Lind B.K., Persson L.M., Edgren M.R., Hedlöf I., and Brahme A. Repairable-conditionally-repairable damage model based on dual Poisson processes. Radiat Res 160 (2003) 366-375
16. Brahme A., and Ågren A.K. Optimal dose distribution for eradication of heterogeneous tumours. Acta Oncol 26 (1987) 377-385
17. Lind B.K., Nilsson J., Löf J., and Brahme A. Generalization of the normalized dose-response gradient to non-uniform dose delivery. Acta Oncol 40 (2001) 718-724
18. Tucker S.L., Thames H.D., and Taylor J.M.G. How well is the probability of tumor cure after fractionated irradiation described by Poisson statistics?. Radiat Res 124 (1990) 273-282
19. Johnson N.L., Kotz S., and Kemp A.W. Univariate discrete distributions. 2nd ed. (1993), John Wiley & Sons Inc.
20. J Nilsson. Accurate description of heterogeneous tumors for biologically optimized radiation therapy. Ph.D. thesis, Department of Medical Radiation Physics, Stockholm University and Karolinska Institutet, Stockholm, Sweden; 2004.
21. Vaupel P., Kallinowski F., and Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 49 (1989) 6449-6465
22. 2 distribution and bioreductive enzymes in human malignant brain tumors. Int J Radiat Oncol Biol Phys 29 (1994) 427-431
23. Vaupel P., Thews O., Kelleher D.K., and Hoeckel M. Current status of knowledge and critical issues in tumor oxygenation. Results from 25 years of research in tumor pathophysiology. Adv Exp Med Biol 454 (1998) 591-602
24. Alper T., and Howard-Flanders P. The role of oxygen in modifying the radiosensitivity of E. coli B. Nature 178 (1956) 978-979
25. Alper T. Cellular radiobiology (1979), Cambridge University Press, Cambridge
26. Brahme A. Development of radiation therapy optimization. Acta Oncol 39 (2000) 579-595
27. Brahme A., Nilsson J., and Belkić D. Biologically optimized radiation therapy. Acta Oncol 40 (2001) 725-734