메뉴 건너뛰기




Volumn 22, Issue 8, 2010, Pages 836-840

Treatment of gastro-esophageal reflux disease: The new kids to block: VIEWPOINT

Author keywords

lower esophageal sphincter; refractory gastro esophageal reflux disease; treatment

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; ADX 10059; AFQ 056; ARBACLOFEN PLACARBIL; AZD 2516; AZD 9343; BACLOFEN; CANNABINOID 1 RECEPTOR AGONIST; CANNABINOID 1 RECEPTOR ANTAGONIST; DRONABINOL; ITOPRIDE; LESOGABERAN; METABOTROPIC RECEPTOR ANTAGONIST; PROTON PUMP INHIBITOR; RIMONABANT; UNCLASSIFIED DRUG;

EID: 77954442076     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2010.01537.x     Document Type: Review
Times cited : (16)

References (37)
  • 1
    • 33746709974 scopus 로고    scopus 로고
    • The Montreal definition and classification of gastroesophageal reflux disease: A global evidence-based consensus
    • Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol 2006 101 : 1900 1920.
    • (2006) Am J Gastroenterol , vol.101 , pp. 1900-1920
    • Vakil, N.1    Van Zanten, S.V.2    Kahrilas, P.3    Dent, J.4    Jones, R.5
  • 2
    • 0027965996 scopus 로고
    • 24-hour pH monitoring in symptomatic patients without erosive esophagitis who did not respond to antireflux treatment
    • Fass R, Mackel C, Sampliner RE. 24-hour pH monitoring in symptomatic patients without erosive esophagitis who did not respond to antireflux treatment. J Clin Gastroenterol 1994 19 : 97 9.
    • (1994) J Clin Gastroenterol , vol.19 , pp. 97-9
    • Fass, R.1    MacKel, C.2    Sampliner, R.E.3
  • 3
    • 0029938339 scopus 로고    scopus 로고
    • Relation between oesophageal acid exposure and healing of oesophagitis with omeprazole in patients with severe reflux oesophagitis
    • Holloway RH, Dent J, Narielvala F, Mackinnon AM. Relation between oesophageal acid exposure and healing of oesophagitis with omeprazole in patients with severe reflux oesophagitis. Gut 1996 38 : 649 654.
    • (1996) Gut , vol.38 , pp. 649-654
    • Holloway, R.H.1    Dent, J.2    Narielvala, F.3    MacKinnon, A.M.4
  • 4
    • 0029821732 scopus 로고    scopus 로고
    • Prolonged ambulatory pH monitoring in patients with persistent gastroesophageal reflux disease symptoms: Testing while on therapy identifies the need for more aggressive anti-reflux therapy
    • Katzka DA, Paoletti V, Leite L, Castell DO. Prolonged ambulatory pH monitoring in patients with persistent gastroesophageal reflux disease symptoms: testing while on therapy identifies the need for more aggressive anti-reflux therapy. Am J Gastroenterol 1996 91 : 2110 2113.
    • (1996) Am J Gastroenterol , vol.91 , pp. 2110-2113
    • Katzka, D.A.1    Paoletti, V.2    Leite, L.3    Castell, D.O.4
  • 5
    • 0025168776 scopus 로고
    • Combined gastric and oesophageal 24-hour pH monitoring and oesophageal manometry in patients with reflux disease, resistant to treatment with omeprazole
    • Klinkenberg-Knol EC, Meuwissen SG. Combined gastric and oesophageal 24-hour pH monitoring and oesophageal manometry in patients with reflux disease, resistant to treatment with omeprazole. Aliment Pharmacol Ther 1990 4 : 485 495.
    • (1990) Aliment Pharmacol Ther , vol.4 , pp. 485-495
    • Klinkenberg-Knol, E.C.1    Meuwissen, S.G.2
  • 6
    • 19944403902 scopus 로고    scopus 로고
    • The lower oesophageal sphincter
    • Boeckxstaens GE. The lower oesophageal sphincter. Neurogastroenterol Motil 2005 17 (Suppl. 1 13 21.
    • (2005) Neurogastroenterol Motil , vol.17 , Issue.SUPPL. 1 , pp. 13-21
    • Boeckxstaens, G.E.1
  • 7
    • 0033678737 scopus 로고    scopus 로고
    • The effects of tegaserod (HTF 919) on oesophageal acid exposure in gastro-oesophageal reflux disease
    • Kahrilas PJ, Quigley EM, Castell DO, Spechler SJ. The effects of tegaserod (HTF 919) on oesophageal acid exposure in gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2000 14 : 1503 1509.
    • (2000) Aliment Pharmacol Ther , vol.14 , pp. 1503-1509
    • Kahrilas, P.J.1    Quigley, E.M.2    Castell, D.O.3    Spechler, S.J.4
  • 8
    • 33745174812 scopus 로고    scopus 로고
    • Effects of a 5-HT(4) receptor agonist on oesophageal function and gastro-oesophageal reflux: Studies using combined impedance-manometry and combined impedance-pH
    • Tutuian R, Mainie I, Allan R et al. Effects of a 5-HT(4) receptor agonist on oesophageal function and gastro-oesophageal reflux: studies using combined impedance-manometry and combined impedance-pH. Aliment Pharmacol Ther 2006 24 : 155 162.
    • (2006) Aliment Pharmacol Ther , vol.24 , pp. 155-162
    • Tutuian, R.1    Mainie, I.2    Allan, R.3
  • 9
    • 23144456466 scopus 로고    scopus 로고
    • Effect of itopride, a new prokinetic, in patients with mild GERD: A pilot study
    • Kim YS, Kim TH, Choi CS et al. Effect of itopride, a new prokinetic, in patients with mild GERD: a pilot study. World J Gastroenterol 2005 11 : 4210 4214.
    • (2005) World J Gastroenterol , vol.11 , pp. 4210-4214
    • Kim, Y.S.1    Kim, T.H.2    Choi, C.S.3
  • 10
    • 77954438764 scopus 로고    scopus 로고
    • Influence of Itopride on esophageal function in man
    • Scarpellini E, Vos R, Vanden BP, Tack J. Influence of Itopride on esophageal function in man. Gastroenterology 2009 136 (Suppl. 1 A 122.
    • (2009) Gastroenterology , vol.136 , Issue.SUPPL. 1 , pp. 122
    • Scarpellini, E.1    Vos, R.2    Vanden, B.P.3    Tack, J.4
  • 11
    • 0034743929 scopus 로고    scopus 로고
    • Site of action of GABA(B) receptor for vagal motor control of the lower esophageal sphincter in ferrets and rats
    • McDermott CM, Abrahams TP, Partosoedarso E et al. Site of action of GABA(B) receptor for vagal motor control of the lower esophageal sphincter in ferrets and rats. Gastroenterology 2001 120 : 1749 1762.
    • (2001) Gastroenterology , vol.120 , pp. 1749-1762
    • McDermott, C.M.1    Abrahams, T.P.2    Partosoedarso, E.3
  • 12
    • 0032720273 scopus 로고    scopus 로고
    • Inhibition of transient les relaxations and reflux in ferrets by GABA receptor agonists
    • Blackshaw LA, Staunton E, Lehmann A, Dent J. Inhibition of transient LES relaxations and reflux in ferrets by GABA receptor agonists. Am J Physiol 1999 277 : G867 74.
    • (1999) Am J Physiol , vol.277 , pp. 867-74
    • Blackshaw, L.A.1    Staunton, E.2    Lehmann, A.3    Dent, J.4
  • 14
    • 0342520880 scopus 로고    scopus 로고
    • Effects of repeated administration of baclofen on transient lower esophageal sphincter relaxation in the dog
    • Lehmann A, Hansson-Branden L, Karrberg L. Effects of repeated administration of baclofen on transient lower esophageal sphincter relaxation in the dog. Eur J Pharmacol 2000 403 : 163 167.
    • (2000) Eur J Pharmacol , vol.403 , pp. 163-167
    • Lehmann, A.1    Hansson-Branden, L.2    Karrberg, L.3
  • 15
    • 0036240152 scopus 로고    scopus 로고
    • Baclofen-mediated gastro-oesophageal acid reflux control in patients with established reflux disease
    • Cange L, Johnsson E, Rydholm H et al. Baclofen-mediated gastro-oesophageal acid reflux control in patients with established reflux disease. Aliment Pharmacol Ther 2002 16 : 869 873.
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 869-873
    • Cange, L.1    Johnsson, E.2    Rydholm, H.3
  • 16
    • 0242500869 scopus 로고    scopus 로고
    • Effect of acute and chronic administration of the GABA B agonist baclofen on 24 hour pH metry and symptoms in control subjects and in patients with gastro-oesophageal reflux disease
    • Ciccaglione AF, Marzio L. Effect of acute and chronic administration of the GABA B agonist baclofen on 24 hour pH metry and symptoms in control subjects and in patients with gastro-oesophageal reflux disease. Gut 2003 52 : 464 470.
    • (2003) Gut , vol.52 , pp. 464-470
    • Ciccaglione, A.F.1    Marzio, L.2
  • 17
    • 0033958395 scopus 로고    scopus 로고
    • Control of transient lower esophageal sphincter relaxations and reflux by the GABA(B) agonist baclofen in normal subjects
    • Lidums I, Lehmann A, Checklin H, Dent J, Holloway RH. Control of transient lower esophageal sphincter relaxations and reflux by the GABA(B) agonist baclofen in normal subjects. Gastroenterology 2000 118 : 7 13.
    • (2000) Gastroenterology , vol.118 , pp. 7-13
    • Lidums, I.1    Lehmann, A.2    Checklin, H.3    Dent, J.4    Holloway, R.H.5
  • 18
    • 0036735045 scopus 로고    scopus 로고
    • The effect of baclofen on gastro-oesophageal reflux, lower oesophageal sphincter function and reflux symptoms in patients with reflux disease
    • Van Herwaarden MA, Samsom M, Rydholm H, Smout AJ. The effect of baclofen on gastro-oesophageal reflux, lower oesophageal sphincter function and reflux symptoms in patients with reflux disease. Aliment Pharmacol Ther 2002 16 : 1655 1662.
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 1655-1662
    • Van Herwaarden, M.A.1    Samsom, M.2    Rydholm, H.3    Smout, A.J.4
  • 19
    • 0347708695 scopus 로고    scopus 로고
    • Baclofen decreases acid and non-acid post-prandial gastro-oesophageal reflux measured by combined multichannel intraluminal impedance and pH
    • Vela MF, Tutuian R, Katz PO, Castell DO. Baclofen decreases acid and non-acid post-prandial gastro-oesophageal reflux measured by combined multichannel intraluminal impedance and pH. Aliment Pharmacol Ther 2003 17 : 243 251.
    • (2003) Aliment Pharmacol Ther , vol.17 , pp. 243-251
    • Vela, M.F.1    Tutuian, R.2    Katz, P.O.3    Castell, D.O.4
  • 20
    • 0141757445 scopus 로고    scopus 로고
    • Effect of the GABA(B) agonist baclofen in patients with symptoms and duodeno-gastro-oesophageal reflux refractory to proton pump inhibitors
    • Koek GH, Sifrim D, Lerut T, Janssens J, Tack J. Effect of the GABA(B) agonist baclofen in patients with symptoms and duodeno-gastro-oesophageal reflux refractory to proton pump inhibitors. Gut 2003 52 : 1397 1402.
    • (2003) Gut , vol.52 , pp. 1397-1402
    • Koek, G.H.1    Sifrim, D.2    Lerut, T.3    Janssens, J.4    Tack, J.5
  • 21
    • 67650461959 scopus 로고    scopus 로고
    • Does the presence of a hiatal hernia affect the efficacy of the reflux inhibitor baclofen during add-on therapy?
    • Beaumont H, Boeckxstaens GE. Does the presence of a hiatal hernia affect the efficacy of the reflux inhibitor baclofen during add-on therapy? Am J Gastroenterol 2009 104 : 1764 1771.
    • (2009) Am J Gastroenterol , vol.104 , pp. 1764-1771
    • Beaumont, H.1    Boeckxstaens, G.E.2
  • 22
    • 33748977207 scopus 로고    scopus 로고
    • Effect of baclofen on esophagogastric motility and gastroesophageal reflux in children with gastroesophageal reflux disease: A randomized controlled trial
    • Omari TI, Benninga MA, Sansom L, Butler RN, Dent J, Davidson GP. Effect of baclofen on esophagogastric motility and gastroesophageal reflux in children with gastroesophageal reflux disease: a randomized controlled trial. J Pediatr 2006 149 : 468 474.
    • (2006) J Pediatr , vol.149 , pp. 468-474
    • Omari, T.I.1    Benninga, M.A.2    Sansom, L.3    Butler, R.N.4    Dent, J.5    Davidson, G.P.6
  • 23
    • 77953232099 scopus 로고    scopus 로고
    • Arbaclofen placarbil decreases postprandial reflux in patients with gastroesophageal reflux disease
    • Gerson LB, Huff FJ, Hila A et al. Arbaclofen placarbil decreases postprandial reflux in patients with gastroesophageal reflux disease. Am J Gastroenterol 2010 105 : 1266 1275.
    • (2010) Am J Gastroenterol , vol.105 , pp. 1266-1275
    • Gerson, L.B.1    Huff, F.J.2    Hila, A.3
  • 24
    • 69949131895 scopus 로고    scopus 로고
    • Arbaclofen placarbil monotherapy decreases GERD symptoms in subjects with previous PPI therapy
    • Suppl. 1): A
    • Nimish B, Vakil N, Huff FJ, Bian A, Jones DS, Stamler D. Arbaclofen placarbil monotherapy decreases GERD symptoms in subjects with previous PPI therapy. Gastroenterology 2009 136 (Suppl. 1): A-79.
    • (2009) Gastroenterology , vol.79-136
    • Nimish, B.1    Vakil, N.2    Huff, F.J.3    Bian, A.4    Jones, D.S.5    Stamler, D.6
  • 25
    • 70349685069 scopus 로고    scopus 로고
    • The GABA(B) receptor agonist AZD9343 inhibits transient lower oesophageal sphincter relaxations and acid reflux in healthy volunteers: A phase i study
    • Beaumont H, Smout A, Aanen M et al. The GABA(B) receptor agonist AZD9343 inhibits transient lower oesophageal sphincter relaxations and acid reflux in healthy volunteers: a phase I study. Aliment Pharmacol Ther 2009 30 : 937 946.
    • (2009) Aliment Pharmacol Ther , vol.30 , pp. 937-946
    • Beaumont, H.1    Smout, A.2    Aanen, M.3
  • 26
    • 77954455153 scopus 로고    scopus 로고
    • Efficacy and tolerability of the novel reflux inhibitor, AZD3355, as add-on treatment in GERD patients with symptoms despite proton pump inhibitor therapy
    • Boeckxstaens G, Beaumont H, Hatlebakk JG, Silberg DG, Adler J, Denison H. Efficacy and tolerability of the novel reflux inhibitor, AZD3355, as add-on treatment in GERD patients with symptoms despite proton pump inhibitor therapy. Gastroenterology 2009 136 (Suppl. 1 A 436.
    • (2009) Gastroenterology , vol.136 , Issue.SUPPL. 1 , pp. 436
    • Boeckxstaens, G.1    Beaumont, H.2    Hatlebakk, J.G.3    Silberg, D.G.4    Adler, J.5    Denison, H.6
  • 27
    • 77951205836 scopus 로고    scopus 로고
    • The novel, peripherally restricted GABAB receptor agonist lesogaberan (AZD3355) inhibits acid reflux and reduces esophageal acid exposure as measured with 24-h pHmetry in dogs
    • Branden L, Fredriksson A, Harring E, Jensen J, Lehmann A. The novel, peripherally restricted GABAB receptor agonist lesogaberan (AZD3355) inhibits acid reflux and reduces esophageal acid exposure as measured with 24-h pHmetry in dogs. Eur J Pharmacol 2010 634 : 138 141.
    • (2010) Eur J Pharmacol , vol.634 , pp. 138-141
    • Branden, L.1    Fredriksson, A.2    Harring, E.3    Jensen, J.4    Lehmann, A.5
  • 28
    • 70350434126 scopus 로고    scopus 로고
    • (R)-(3-amino-2-fluoropropyl) phosphinic acid (AZD3355), a novel GABAB receptor agonist, inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action
    • Lehmann A, Antonsson M, Holmberg AA et al. (R)-(3-amino-2-fluoropropyl) phosphinic acid (AZD3355), a novel GABAB receptor agonist, inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action. J Pharmacol Exp Ther 2009 331 : 504 512.
    • (2009) J Pharmacol Exp Ther , vol.331 , pp. 504-512
    • Lehmann, A.1    Antonsson, M.2    Holmberg, A.A.3
  • 29
    • 77955502520 scopus 로고    scopus 로고
    • Effects of lesogaberan, a novel GABA(B)-receptor agonist, on reflux and lower esophageal sphincter function in patients with gastroesophageal reflux disease
    • DOI:.
    • Boeckxstaens GE, Beaumont H, Mertens V et al. Effects of lesogaberan, a novel GABA(B)-receptor agonist, on reflux and lower esophageal sphincter function in patients with gastroesophageal reflux disease. Gastroenterology 2010 DOI:.
    • (2010) Gastroenterology
    • Boeckxstaens, G.E.1    Beaumont, H.2    Mertens, V.3
  • 30
    • 14944374399 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors inhibit mechanosensitivity in vagal sensory neurons
    • Page AJ, Young RL, Martin CM et al. Metabotropic glutamate receptors inhibit mechanosensitivity in vagal sensory neurons. Gastroenterology 2005 128 : 402 410.
    • (2005) Gastroenterology , vol.128 , pp. 402-410
    • Page, A.J.1    Young, R.L.2    Martin, C.M.3
  • 31
    • 24144487047 scopus 로고    scopus 로고
    • Inhibition of transient lower esophageal sphincter relaxation and gastroesophageal reflux by metabotropic glutamate receptor ligands
    • Frisby CL, Mattsson JP, Jensen JM, Lehmann A, Dent J, Blackshaw LA. Inhibition of transient lower esophageal sphincter relaxation and gastroesophageal reflux by metabotropic glutamate receptor ligands. Gastroenterology 2005 129 : 995 1004.
    • (2005) Gastroenterology , vol.129 , pp. 995-1004
    • Frisby, C.L.1    Mattsson, J.P.2    Jensen, J.M.3    Lehmann, A.4    Dent, J.5    Blackshaw, L.A.6
  • 32
    • 53349102069 scopus 로고    scopus 로고
    • Is there a unifying role for visceral hypersensitivity and irritable bowel syndrome in non-erosive reflux disease?
    • Tack J. Is there a unifying role for visceral hypersensitivity and irritable bowel syndrome in non-erosive reflux disease? Digestion 2008 78 (Suppl. 1 42 5.
    • (2008) Digestion , vol.78 , Issue.SUPPL. 1 , pp. 42-5
    • Tack, J.1
  • 33
    • 77954407168 scopus 로고    scopus 로고
    • Efficacy, tolerability and pharmacokinetics of a modified release formulation of ADX10059, a negative allosteric modulator of metabotropic glutamate receptor 5: An esophageal pH-impedance study in healthy subjects
    • DOI:.
    • Zerbib F, Keywood C, Strabach G. Efficacy, tolerability and pharmacokinetics of a modified release formulation of ADX10059, a negative allosteric modulator of metabotropic glutamate receptor 5: an esophageal pH-impedance study in healthy subjects. Neurogastroenterol Motil 2010 DOI:.
    • (2010) Neurogastroenterol Motil
    • Zerbib, F.1    Keywood, C.2    Strabach, G.3
  • 34
    • 77954447180 scopus 로고    scopus 로고
    • Effect of mGLUR5 negative allosteric modulator (NAM) ADX10059, monotherapy, on reflux events and lower esophageal sphincter (LES) function in patients with gastro - Esophageal reflux disease (GERD)
    • May. Suppl. 1)
    • Bruley Des Varannes S, Tutuian R, Roman S et al. Effect of mGLUR5 negative allosteric modulator (NAM) ADX10059, monotherapy, on reflux events and lower esophageal sphincter (LES) function in patients with gastro - esophageal reflux disease (GERD). Gastroenterology May 2010 138 (Suppl. 1) : S13.
    • (2010) Gastroenterology , vol.138 , pp. 13
    • Bruley Des Varannes, S.1    Tutuian, R.2    Roman, S.3
  • 35
    • 0037592289 scopus 로고    scopus 로고
    • Cannabinoid1 receptor in the dorsal vagal complex modulates lower oesophageal sphincter relaxation in ferrets
    • Partosoedarso ER, Abrahams TP, Scullion RT, Moerschbaecher JM, Hornby PJ. Cannabinoid1 receptor in the dorsal vagal complex modulates lower oesophageal sphincter relaxation in ferrets. J Physiol 2003 550 : 149 158.
    • (2003) J Physiol , vol.550 , pp. 149-158
    • Partosoedarso, E.R.1    Abrahams, T.P.2    Scullion, R.T.3    Moerschbaecher, J.M.4    Hornby, P.J.5
  • 36
    • 62249182719 scopus 로고    scopus 로고
    • Effect of delta9-tetrahydrocannabinol, a cannabinoid receptor agonist, on the triggering of transient lower oesophageal sphincter relaxations in dogs and humans
    • Beaumont H, Jensen J, Carlsson A, Ruth M, Lehmann A, Boeckxstaens G. Effect of delta9-tetrahydrocannabinol, a cannabinoid receptor agonist, on the triggering of transient lower oesophageal sphincter relaxations in dogs and humans. Br J Pharmacol 2009 156 : 153 162.
    • (2009) Br J Pharmacol , vol.156 , pp. 153-162
    • Beaumont, H.1    Jensen, J.2    Carlsson, A.3    Ruth, M.4    Lehmann, A.5    Boeckxstaens, G.6
  • 37
    • 77954438764 scopus 로고    scopus 로고
    • Influence of the cannabinoid type 1 receptor Rimonabant on esophageal function in man
    • Scarpellini E, Vos R, Vanden BP, Tack J. Influence of the cannabinoid type 1 receptor Rimonabant on esophageal function in man. Gastroenterology 2009 136 (Suppl. 1 A 122.
    • (2009) Gastroenterology , vol.136 , Issue.SUPPL. 1 , pp. 122
    • Scarpellini, E.1    Vos, R.2    Vanden, B.P.3    Tack, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.