Is there a unifying role for visceral hypersensitivity and irritable bowel syndrome in non-erosive reflux disease?

Digestion

Volumn 78, Issue SUPPL. 1, 2008, Pages 42-45

  Tack, Jan ^a,b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Functional bowel disorders; Gastroesophageal reflux disease; Non erosive reflux disease; Visceral sensitivity

Indexed keywords

CONFERENCE PAPER; DISEASE SEVERITY; GASTROESOPHAGEAL REFLUX; HEARTBURN; HYPERSENSITIVITY; IRRITABLE COLON; MECHANICAL STIMULATION; NON EROSIVE REFLUX DISEASE; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REFLUX ESOPHAGITIS; STOMACH ACID SECRETION; SYMPTOM; VISCERA;

ENDOSCOPY, DIGESTIVE SYSTEM; ESOPHAGEAL SPHINCTER, LOWER; GASTRIC ACID; GASTRIC EMPTYING; GASTROESOPHAGEAL REFLUX; HUMANS; IRRITABLE BOWEL SYNDROME; RISK FACTORS;

EID: 53349102069     PISSN: 00122823     EISSN: None     Source Type: Journal    
DOI: 10.1159/000151254     Document Type: Conference Paper

References (29)

1. Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R, Global Consensus Group: The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol 2006;101:1900-1920.
2. Dent J, El-Serag HB, Wallander MA, Johansson S: Epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut 2005;54:710-717.
3. Ang D, Sifrim D, Tack J: Mechanisms of heartburn. Nat Clin Pract Gastroenterol Hepatol 2008, Epub ahead of print.
4. Tack J, Fass R: Review article: approaches to endoscopic-negative reflux disease: part of the GERD spectrum or a unique acid-related disorder? Aliment Pharmacol Ther 2004;19(suppl 1):28-34.
5. Martinez SD, Malagon IB, Garewal HS, Hui H, Fass R: Non-erosive reflux disease (NERD)-acid reflux and symptom patterns. Aliment Pharmacol Ther 2003;17:537-545.
6. Trimble K, Pryde A, Heading R: Lowered esophageal sensory thresholds in patients with symptomatic but not excess gastroesophageal reflux: evidence for a spectrum of visceral sensitivity in GORD. Gut 1995;37:7-12.
7. Galmiche JP, Clouse RE, Bálint A, Cook IJ, Kahrilas PJ, Paterson WG, Smout AJ: Functional esophageal disorders. Gastroenterology 2006;130:1459-1465.
8. Fass R, Naliboff BD, Fass SS, Peleg N, Wendel C, Malagon IB, Mayer EA: The effect of auditory stress on perception of intraesophageal acid in patients with gastroesophageal reflux disease. Gastroenterology 2008;134:696-705.
9. Howard PJ, Maher L, Pryde A, Heading RC: Symptomatic gastro-oesophageal reflux, abnormal oesophageal acid exposure, and mucosal acid sensitivity are three separate, though related, aspects of gastro-oesophageal reflux disease. Gut 1991;32:128-132.
10. Shapiro M, Green C, Bautista JM, Peru RL, Malagon IB, Corvo M, Risner-Adler S, Beeler JN, Tuchinsky I, Fass R: Functional heartburn patients demonstrate traits of functional bowel disorder but lack a uniform increase of chemoreceptor sensitivity to acid. Am J Gastroenterol 2006;101:1084-1091.
11. Fass R, Naliboff B, Higa L, Johnson C, Kodner A, Munakata J, Ngo J, Mayer EA: Differential effect of long-term esophageal acid exposure on mechanosensitivity and chemosensitivity in humans. Gastroenterology 1998;115:1363-1373.
12. Rodriguez-Stanley S, Zubaidi S, Ciociola A, et al: Are patients with functional heartburn sensitive to both mechanical and chemical stimuli? Am J Gastroenterol 2002;97:A115.
13. Yang M, Li ZS, Xu XR, Fang DC, Zou DW, Xu GM, Sun ZX, Tu ZX: Characterization of cortical potentials evoked by oesophageal balloon distention and acid perfusion in patients with functional heartburn. Neurogastroenterol Motil 2006;18:292-299.
14. Reddy H, Staahl C, Arendt-Nielsen L, Gregersen H, Drewes AM, Funch-Jensen P: Sensory and biomechanical properties of the esophagus in non-erosive reflux disease. Scand J Gastroenterol 2007;42:432-440.
15. Siddiqui A, Rodriguez-Stanley S, Zubaidi S, Miner PB Jr: Esophageal visceral sensitivity to bile salts in patients with functional heart-burn and in healthy control subjects. Dig Dis Sci 2005;50:81-85.
16. Hobson AR, Furlong PL, Aziz Q: Oesophageal afferent pathway sensitivity in non-erosive reflux disease. Neurogastroenterol Motil 2008, Epub ahead of print.
17. Trimble KC, Farouk R, Pryde A, Douglas S, Heading RC: Heightened visceral sensation in functional gastrointestinal disease is not site-specific. Evidence for a generalized disorder of gut sensitivity. Dig Dis Sci 1995;40:1607-1613.
18. Locke GR 3rd, Zinsmeister AR, Fett SL, Melton LJ 3rd, Talley NJ: Overlap of gastrointestinal symptom complexes in a US community. Neurogastroenterol Motil 2005;17:29-34.
19. Corazziari E: Definition and epidemiology of functional gastrointestinal disorders. Best Pract Res Clin Gastroenterol 2004;18:613.
20. Talley NJ, Dennis EH, Schettler-Duncan VA, Lacy BE, Olden KW, Crowell MD: Overlapping upper and lower gastrointestinal symptoms in irritable bowel syndrome patients with constipation or diarrhea. Am J Gastroenterol 2003;98:2454-2459.
21. Sarkar S, Aziz Q, Woolf CJ, Hobson AR, Thompson DG: Contribution of central sensitization to the development of non cardiac chest pain. Lancet 2000;356:1154-1159.
22. Bradley LA, Richter JE, Pulliam TJ, Haile JM, Scarinci IC, Schan CA, Dalton CB, Salley AN: The relationship between stress and symptoms of gastroesophageal reflux: the influence of psychological factors. Am J Gastroenterol 1993;88:11-19.
23. Schey R, Dickman R, Parthasarathy S, Quan SF, Wendel C, Merchant J, Powers J, Han B, van Handel D, Fass R: Sleep deprivation is hyperalgesic in patients with gastroesophageal reflux disease. Gastroenterology 2007;133:1787-1795.
24. Matthews PJ, Aziz Q, Facer P, Davis JB, Thompson DG, Anand P: Increased capsaicin receptor TRPV1 nerve fibres in the inflamed human oesophagus. Eur J Gastroenterol Hepatol 2004;16:897-902.
25. Yoshida N, Suzuki M, Kamata K, Handa O, Takagi T, Kokura S, Ichikawa H, Naito Y, Kuramoto H, Yoshikawa T, Okanoue T: Role of nociceptors/neuropeptides pathway in the pathogenesis of heartburn in nonerosive reflux disease (abstract). Gastroenterology 2007;132:A274.
26. Tobey NA, Carson JL, Alkiek RA, Orlando RC: Dilated intercellular spaces: a morphological feature of acid reflux-damaged human esophageal epithelium. Gastroenterology 1996;111:1200-1205.
27. Mehta AJ, de Caestecker JS, Camm AJ, Northfield TC: Sensitization to painful distension and abnormal sensory perception in the esophagus. Gastroenterology 1995;108:311-319.
28. Peghini PL, Johnston BT, Leite LP, Castell DO: Mucosal acid exposure sensitizes a subset of normal subjects to intra-esophageal balloon distension. Eur J Gastroenterol Hepatol 1996;8:979-983.
29. Farré R, De Vos R, Geboes K, Verbecke K, Vanden Berghe P, Depoortere I, Blondeau K, Tack J, Sifrim D: Critical role of stress in increased oesophageal mucosa permeability and dilated intercellular spaces. Gut 2007;56:1191-1197.