메뉴 건너뛰기




Volumn 127, Issue 3, 2010, Pages 521-531

INSL3 has tumor-promoting activity in thyroid cancer

Author keywords

Angiogenesis; Human; INSL3; RXFP2; S100A4; Thyroid cancer

Indexed keywords

AGAR; CALVASCULIN; CRE RECOMBINASE; INSULIN LIKE PEPTIDE 3; PEPTIDE HORMONE; UNCLASSIFIED DRUG; VASCULOTROPIN;

EID: 77954439887     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.25068     Document Type: Article
Times cited : (33)

References (58)
  • 3
    • 0029953794 scopus 로고    scopus 로고
    • Molecular cloning and expression of the relaxin-like factor from the mouse testis
    • DOI 10.1210/en.137.7.3009
    • Pusch W, Balvers M, Ivell R. Molecular cloning and expression of the relaxin-like factor from the mouse testis. Endocrinology 1996;137:3009-13. (Pubitemid 26192198)
    • (1996) Endocrinology , vol.137 , Issue.7 , pp. 3009-3013
    • Pusch, W.1    Balvers, M.2    Ivell, R.3
  • 4
    • 0027365039 scopus 로고
    • Cloning of a cDNA for a novel insulin-like peptide of the testicular Leydig cells
    • Adham IM, Burkhardt E, Benahmed M, Engel W. Cloning of a cDNA for a novel insulin-like peptide of the testicular Leydig cells. J Biol Chem 1993;268:26668-72. (Pubitemid 23361751)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.35 , pp. 26668-26672
    • Adham, I.M.1    Burkhardt, E.2    Benahmed, M.3    Engel, W.4
  • 5
    • 17644415042 scopus 로고    scopus 로고
    • LGR8 signal activation by the relaxin-like factor
    • Bullesbach EE, Schwabe C. LGR8 signal activation by the relaxin-like factor. J Biol Chem 2005;280:14586-90.
    • (2005) J Biol Chem , vol.280 , pp. 14586-14590
    • Bullesbach, E.E.1    Schwabe, C.2
  • 8
    • 33845939640 scopus 로고    scopus 로고
    • Comparison of signaling pathways activated by the relaxin family peptide receptors, RXFP1 and RXFP2, using reporter genes
    • Halls ML, Bathgate RA, Summers RJ. Comparison of signaling pathways activated by the relaxin family peptide receptors, RXFP1 and RXFP2, using reporter genes. J Pharmacol Exp Ther 2007;320:281-90.
    • (2007) J Pharmacol Exp Ther , vol.320 , pp. 281-290
    • Halls, M.L.1    Bathgate, R.A.2    Summers, R.J.3
  • 9
    • 33947324489 scopus 로고    scopus 로고
    • Relaxin family peptide receptors - Former orphans reunite with their parent ligands to activate multiple signalling pathways
    • Halls ML, van der Westhuizen ET, Bathgate RA, Summers RJ. Relaxin family peptide receptors - former orphans reunite with their parent ligands to activate multiple signalling pathways. Br J Pharmacol 2007;150:677-91.
    • (2007) Br J Pharmacol , vol.150 , pp. 677-691
    • Halls, M.L.1    Van Der Westhuizen, E.T.2    Bathgate, R.A.3    Summers, R.J.4
  • 11
    • 0032989104 scopus 로고    scopus 로고
    • Cryptorchidism in mice mutant for Insl3
    • Nef S, Parada LF. Cryptorchidism in mice mutant for Insl3. Nat Genet 1999;22:295-9.
    • (1999) Nat Genet , vol.22 , pp. 295-299
    • Nef, S.1    Parada, L.F.2
  • 14
    • 38749091351 scopus 로고    scopus 로고
    • Relaxin and related peptides in male reproduction
    • Agoulnik AI. Relaxin and related peptides in male reproduction. Adv Exp Med Biol 2007;612:49-64.
    • (2007) Adv Exp Med Biol , vol.612 , pp. 49-64
    • Agoulnik, A.I.1
  • 17
    • 27944447704 scopus 로고    scopus 로고
    • H2 relaxin overexpression increases in vivo prostate xenograft tumor growth and angiogenesis
    • Silvertown JD, Ng J, Sato T, Summerlee AJ, Medin JA. H2 relaxin overexpression increases in vivo prostate xenograft tumor growth and angiogenesis. Int J Cancer 2006;118:62-73.
    • (2006) Int J Cancer , vol.118 , pp. 62-73
    • Silvertown, J.D.1    Ng, J.2    Sato, T.3    Summerlee, A.J.4    Medin, J.A.5
  • 21
    • 33645504073 scopus 로고    scopus 로고
    • The R273H p53 mutation can facilitate the androgen-independent growth of LNCaP by a mechanism that involves H2 relaxin and its cognate receptor LGR7
    • Vinall RL, Tepper CG, Shi XB, Xue LA, Gandour-Edwards R, de Vere White RW. The R273H p53 mutation can facilitate the androgen-independent growth of LNCaP by a mechanism that involves H2 relaxin and its cognate receptor LGR7. Oncogene 2006;25:2082-93.
    • (2006) Oncogene , vol.25 , pp. 2082-2093
    • Vinall, R.L.1    Tepper, C.G.2    Shi, X.B.3    Xue, L.A.4    Gandour-Edwards, R.5    De Vere White, R.W.6
  • 25
    • 4644313216 scopus 로고    scopus 로고
    • Genetic targeting of relaxin and insulin-like factor 3 receptors in mice
    • DOI 10.1210/en.2004-0515
    • Kamat AA, Feng S, Bogatcheva NV, Truong A, Bishop CE, Agoulnik AI. Genetic targeting of relaxin and insulin-like factor 3 receptors in mice. Endocrinology 2004;145:4712-20. (Pubitemid 39281465)
    • (2004) Endocrinology , vol.145 , Issue.10 , pp. 4712-4720
    • Kamat, A.A.1    Feng, S.2    Bogatcheva, N.V.3    Truong, A.4    Bishop, C.E.5    Agoulnik, A.I.6
  • 26
    • 64549087596 scopus 로고    scopus 로고
    • Lysosomal acid hydrolases of the cathepsin family are novel targets of INSL3 in human thyroid carcinoma cells
    • Bialek J, Hombach-Klonisch S, Fiebig B, Weber E, Hoang-Vu C, Klonisch T. Lysosomal acid hydrolases of the cathepsin family are novel targets of INSL3 in human thyroid carcinoma cells. Ann NY Acad Sci 2009;1160:361-6.
    • (2009) Ann NY Acad Sci , vol.1160 , pp. 361-366
    • Bialek, J.1    Hombach-Klonisch, S.2    Fiebig, B.3    Weber, E.4    Hoang-Vu, C.5    Klonisch, T.6
  • 30
    • 33845933437 scopus 로고    scopus 로고
    • Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules
    • Scott DJ, Layfield S, Yan Y, Sudo S, Hsueh AJ, Tregear GW, Bathgate RA. Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules. J Biol Chem 2006;281:34942-54.
    • (2006) J Biol Chem , vol.281 , pp. 34942-34954
    • Scott, D.J.1    Layfield, S.2    Yan, Y.3    Sudo, S.4    Hsueh, A.J.5    Tregear, G.W.6    Bathgate, R.A.7
  • 33
    • 34447312179 scopus 로고    scopus 로고
    • Elevated plasma levels of the novel hormone INSL3 in a woman with metastatic ovarian cancer
    • Rossato M, Barban M, Vettor R. Elevated plasma levels of the novel hormone INSL3 in a woman with metastatic ovarian cancer. Int J Biol Markers 2007;22:159-60. (Pubitemid 47062221)
    • (2007) International Journal of Biological Markers , vol.22 , Issue.2 , pp. 159-160
    • Rossato, M.1    Barban, M.2    Vettor, R.3
  • 34
    • 35349011589 scopus 로고    scopus 로고
    • Insulin-like factor 3 levels in cord blood and serum from children: Effects of age, postnatal hypothalamic-pituitary-gonadal axis activation, and cryptorchidism
    • Bay K, Virtanen HE, Hartung S, Ivell R, Main KM, Skakkebaek NE, Andersson AM, Toppari J. Insulin-like factor 3 levels in cord blood and serum from children: effects of age, postnatal hypothalamic-pituitary-gonadal axis activation, and cryptorchidism. J Clin Endocrinol Metab 2007;92:4020-7.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 4020-4027
    • Bay, K.1    Virtanen, H.E.2    Hartung, S.3    Ivell, R.4    Main, K.M.5    Skakkebaek, N.E.6    Andersson, A.M.7    Toppari, J.8
  • 38
    • 33750207622 scopus 로고    scopus 로고
    • Relaxin expression from tumor-targeting adenoviruses and its intratumoral spread, apoptosis induction, and efficacy
    • Kim JH, Lee YS, Kim H, Huang JH, Yoon AR, Yun CO. Relaxin expression from tumor-targeting adenoviruses and its intratumoral spread, apoptosis induction, and efficacy. J Natl Cancer Inst 2006;98:1482-93.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 1482-1493
    • Kim, J.H.1    Lee, Y.S.2    Kim, H.3    Huang, J.H.4    Yoon, A.R.5    Yun, C.O.6
  • 40
    • 11144248392 scopus 로고    scopus 로고
    • The extent to which relaxin promotes proliferation and inhibits apoptosis of cervical epithelial and stromal cells is greatest during late pregnancy in rats
    • Lee HY, Zhao S, Fields PA, Sherwood OD. The extent to which relaxin promotes proliferation and inhibits apoptosis of cervical epithelial and stromal cells is greatest during late pregnancy in rats. Endocrinology 2005;146:511-8.
    • (2005) Endocrinology , vol.146 , pp. 511-518
    • Lee, H.Y.1    Zhao, S.2    Fields, P.A.3    Sherwood, O.D.4
  • 43
    • 65849353240 scopus 로고    scopus 로고
    • Relaxin reduces xenograft tumour growth of human MDA-MB-231 breast cancer cells
    • Radestock Y, Hoang-Vu C, Hombach-Klonisch S. Relaxin reduces xenograft tumour growth of human MDA-MB-231 breast cancer cells. Breast Cancer Res 2008;10:R71.
    • (2008) Breast Cancer Res , vol.10
    • Radestock, Y.1    Hoang-Vu, C.2    Hombach-Klonisch, S.3
  • 44
    • 23644433686 scopus 로고    scopus 로고
    • Relaxin downregulates the calcium binding protein S100A4 in MDA-MB-231 human breast cancer cells
    • DOI 10.1196/annals.1282.070
    • Radestock Y, Hoang-Vu C, Hombach-Klonisch S. Relaxin downregulates the calcium binding protein S100A4 in MDAMB-231 human breast cancer cells. Ann NY Acad Sci 2005;1041:462-9. (Pubitemid 41132287)
    • (2005) Annals of the New York Academy of Sciences , vol.1041 , pp. 462-469
    • Radestock, Y.1    Hoang-Vu, C.2    Hombach-Klonisch, S.3
  • 46
    • 27944470605 scopus 로고    scopus 로고
    • S100A4 (Mts1) gene overexpression is associated with invasion and metastasis of papillary thyroid carcinoma
    • Zou M, Al-Baradie RS, Al-Hindi H, Farid NR, Shi Y. S100A4 (Mts1) gene overexpression is associated with invasion and metastasis of papillary thyroid carcinoma. Br J Cancer 2005;93:1277-84.
    • (2005) Br J Cancer , vol.93 , pp. 1277-1284
    • Zou, M.1    Al-Baradie, R.S.2    Al-Hindi, H.3    Farid, N.R.4    Shi, Y.5
  • 49
    • 3843095048 scopus 로고    scopus 로고
    • Extracellular S100A4(mts1) stimulates invasive growth of mouse endothelial cells and modulates MMP-13 matrix metalloproteinase activity
    • Schmidt-Hansen B, Ornas D, Grigorian M, Klingelhofer J, Tulchinsky E, Lukanidin E, Ambartsumian N. Extracellular S100A4(mts1) stimulates invasive growth of mouse endothelial cells and modulates MMP-13 matrix metalloproteinase activity. Oncogene 2004;23:5487-95.
    • (2004) Oncogene , vol.23 , pp. 5487-5495
    • Schmidt-Hansen, B.1    Ornas, D.2    Grigorian, M.3    Klingelhofer, J.4    Tulchinsky, E.5    Lukanidin, E.6    Ambartsumian, N.7
  • 50
    • 34249779224 scopus 로고    scopus 로고
    • Grape seed proanthocyanidin extracts inhibit vascular cell adhesion molecule expression induced by advanced glycation end products through activation of peroxisome proliferators-activated receptor gamma
    • Ma L, Gao HQ, Li BY, Ma YB, You BA, Zhang FL. Grape seed proanthocyanidin extracts inhibit vascular cell adhesion molecule expression induced by advanced glycation end products through activation of peroxisome proliferators-activated receptor gamma. J Cardiovasc Pharmacol 2007;49:293-8.
    • (2007) J Cardiovasc Pharmacol , vol.49 , pp. 293-298
    • Ma, L.1    Gao, H.Q.2    Li, B.Y.3    Ma, Y.B.4    You, B.A.5    Zhang, F.L.6
  • 53
    • 33749331604 scopus 로고    scopus 로고
    • Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products
    • Yammani RR, Carlson CS, Bresnick AR, Loeser RF. Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: role of the receptor for advanced glycation end products. Arthritis Rheum 2006;54:2901-11.
    • (2006) Arthritis Rheum , vol.54 , pp. 2901-2911
    • Yammani, R.R.1    Carlson, C.S.2    Bresnick, A.R.3    Loeser, R.F.4
  • 55
    • 0034255167 scopus 로고    scopus 로고
    • Immunostained cathepsins B and L correlate with depth of invasion and different metastatic pathways in early stage gastric carcinoma
    • Dohchin A, Suzuki JI, Seki H, Masutani M, Shiroto H, Kawakami Y. Immunostained cathepsins B and L correlate with depth of invasion and different metastatic pathways in early stage gastric carcinoma. Cancer 2000;89:482-7.
    • (2000) Cancer , vol.89 , pp. 482-487
    • Dohchin, A.1    Suzuki, J.I.2    Seki, H.3    Masutani, M.4    Shiroto, H.5    Kawakami, Y.6
  • 56
    • 0034903658 scopus 로고    scopus 로고
    • Cathepsin L antisense oligonucleotides in a human osteosarcoma cell line: Effects on the invasive phenotype
    • Krueger S, Kellner U, Buehling F, Roessner A. Cathepsin L antisense oligonucleotides in a human osteosarcoma cell line: effects on the invasive phenotype. Cancer Gene Ther 2001;8:522-8.
    • (2001) Cancer Gene Ther , vol.8 , pp. 522-528
    • Krueger, S.1    Kellner, U.2    Buehling, F.3    Roessner, A.4
  • 58
    • 0028087881 scopus 로고
    • Metastatic models of human cancer xenografted in the nude mouse: The importance of orthotopic transplantation
    • Kubota T. Metastatic models of human cancer xenografted in the nude mouse: the importance of orthotopic transplantation. J Cell Biochem 1994;56:4-8. (Pubitemid 24288103)
    • (1994) Journal of Cellular Biochemistry , vol.56 , Issue.1 , pp. 4-8
    • Kubota, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.