INSIG2 promoter variant, obesity markers and lipid parameters - No association in a large Slavonic Caucasian population sample

Folia Biologica

Volumn 56, Issue 3, 2010, Pages 131-134

  Hubáček, Jaroslav A ^a,b,c   Kuthanova L ^a   Bohuslavova R ^a,b   Adamkova V ^a,c   Lanska V ^a   Meitinger, T ^d   Pfeufer, A ^d  

^a INSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINE   (Czech Republic)

^b Center for Cardiovascular Research   (Czech Republic)

^c UNIVERSITY OF SOUTH BOHEMIA   (Czech Republic)

^d Institute of Epidemiology Helmholtz Centrum   (Germany)

Author keywords

BMI; INSIG; Polymorphism

Indexed keywords

FATTY ACID; GENE PRODUCT; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; INSIG2 PROTEIN, HUMAN; LIPID; MEMBRANE PROTEIN; SIGNAL PEPTIDE;

ADULT; AGED; ARTICLE; BODY MASS; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; CZECH REPUBLIC; DIABETES MELLITUS; DISEASE ASSOCIATION; ETHNICITY; FEMALE; GENE; GENE FREQUENCY; GENOTYPE; HUMAN; INSULIN INDUCED GENE 2; MAJOR CLINICAL STUDY; MALE; OBESITY; POPULATION GENETICS; SINGLE NUCLEOTIDE POLYMORPHISM; TRIACYLGLYCEROL BLOOD LEVEL; WAIST HIP RATIO; BLOOD; CAUCASIAN; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; PROMOTER REGION;

ADULT; AGED; BODY MASS INDEX; CZECH REPUBLIC; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPIDS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; OBESITY; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC;

EID: 77954420382     PISSN: 00155500     EISSN: 25337602     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Day, I. N., Humphries, S. E. (1994) Electrophoresis for genotyping: microtiter array diagonal gel electrophoresis on horizontal Polyacrylamide gels, hydrolink, or agarose. Anal. Biochem. 222, 389-395.
2. Deng, H. W., Deng, H., Liu, Y. J., Liu, Y. Z., Xu, F. H., Shen, H., Conway, T., Li, J. L., Juany, Q. Y., Davies, K. M., Recker, R. R. (2002) A genomewide linkage scan for quantitative-trait loci for obesity phenotypes. Am. J. Hum. Genet. 70, 1138-1151.
3. Dina, C., Meyre, D., Samon, C., Tichet, J., Marre, M., Jouret, B., Charles, M. A., Balkau, B., Froguel, P. (2007) Comment on "A common genetic variant is associated with adult and childhood obesity". Science 315, 187.
4. Hall, D. H., Rahman, T., Avery, P. J., Keavney, B. (2006) INSIG-2 promoter polymorphism and obesity related phenotypes: association study in 1428 members of 248 families. BMC Med. Genet. 7, 83.
5. Herbert, A., Gerry, N. P., McQueen, M. B., Heid, I. M., Pfeufer, A., Illky, T., Wichmann, H. E., Meitinger, T., Hunter, D., Hu, F. B., Colditz, G., Hinney, A., Hebebrand, J., Koberwitz, K., Zhu, X., Cooper, R., Ardlie, K., Lyon, H., Hirschhorn, J. N., Laure, N. M., Lenburg, M. E., Lange, C., Christman, M. F. (2006) A common genetic variant is associated with adult and childhood obesity. Science 312, 279-283.
6. Hubáček, J. A., Bohuslavová, R., Škodová, Z., Adámková, V. (2007) Variants within the ghrelin gene - association with HDL-cholesterol, but not with body mass index. Folia Biol. (Praha) 53, 202-206.
7. Hubáček, J. A. (2009) Eat less and exercise more - is it really enough to knock down the obesity pandemia? Physiol. Res. 58, Supl 1, S1-S6.
8. Korbonits, M., Gueorguiev, M., O'Grady, E., Lecoeur, C., Swan, D. C., Mein, C. A., Weill, J., Grossman, A. B., Froguel, P. (2002) A variation in the ghrelin gene increases weight and decreases insulin secretion in tall, obese children. J. Clin. Endocrinol. Metab. 87, 4005-4008.
9. Kumar, J., Sunkishala, R. R., Karthikeyan, G., Sengupta, S. (2007) The common genetic variant upstream of INSIG2 gene is not associated with obesity in Indian population. Clin. Genet. 71, 415-418.
10. Liu, Y. J., Xu, F. H., Shen, H., Liu, Y. Z., Deng, H. Y., Zhao, L. J., Juany, O. Y., Dvornyk, V., Conway, T., Davies, K. M., Li, J. L., Recker, R. R., Deng, H. W. (2004) A follow-up linkage study for quantitative trait loci contributing to obesity-related phenotypes. J. Clin. Endocrinol. Metab. 89, 875-882.
11. Loos, R. J., Barroso, I., O'Rahilly, S., Wareham, N. J. (2007) Comment on "A common genetic variant is associated with adult and childhood obesity". Science 315, 187.
12. Lyon, H. N., Emilsson, V., Hinney, A., Heid, M., Lasky-Su, J., Zhu, X., Thorleifsson, G., Gunnarsdottir, S., Walters, G. B., Thorsteinsdotir, U., Kong, A., Gulcher, J., Nguyen, T. T., Scherag, A., Pfeufer, A., Meitinger, T., Brönner, G., Rief, W., Soto-Quiros, M. E., Avila, L., Klanderman, B., Raby, B. A., Silverman, E. K., Weiss, S. T., Laird, N., Ding, X., Groop, L., Tuomi, T., Isomaa, B., Bengtsson, K., Butler, J. L., Cooper, R. S., Fox, C. S., O'Donnell, C. J., Vollmert, C., Celedón, J. C., Wichmann, H. E., Hebebrand, J., Stefansson, K., Lange, C., Hirschhorn, J. N. (2007) The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet. 3, e61.
13. MacDonald, I. (2007) Viewpoint: Obesity in Europe. Circulation 115, f69-f71.
14. Miller, S. A., Dykes, D. D., Polesky, H. F. (1988) A simple salting out procedure for DNA extraction from human nucleated cells. Nucleic Acids Res. 16, 1215.
15. Rosskopf, D., Bornhorst, A., Rimmbach, C., Schwann, C., Kayser, A., Krüger, A. Tessmann, G., Geissler, I., Kroemer, H. K., Völzke, H. (2007) Comment on "A common genetic variant is associated with adult and childhood obesity." Science 315, 187.
16. Slawik, M., Beuschlein, F. (2006) Genetik und Pathophysiologie der Adipositas. Internist 47, 120-129.
17. Ukkola, O., Ravussin, E., Jacobson, P., Pérusse, L., Rankinen, T., Tschöp, M., Heiman, M. L., Leon, A. S., Rao, D. C., Skinner, J. S., Wilmore, J. H., Sjöström, L., Bouchard, C. (2002) Role of ghrelin polymorphisms in obesity based on three different studies. Obes. Res. 10, 782-791.
18. WHO (1983) Multinational monitoring of trends and determinants in cardiovascular diseases - MONICA Project. Manual of operations WHO/MNC 82.2, Nov. 1983.
19. Yabe, D., Brown, M. S., Goldstein, J. L. (2002) Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Proc. Natl. Acad. Sci. USA 99, 12753-12758.
20. Yang, T., Espenshade, P. J ., Wright, M. E., Yabe, D., Gong, Y., Aebersold, R., Goldstein, J. L., Brown, M. S. (2002) Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. Cell 110, 489-500.