The endothelial-to-mesenchymal transition process

Revista Latinoamericana de Hipertension

Volumn 5, Issue 1, 2010, Pages 1-5

  Carrillo P, Luz Marina ^a   Arciniegas C, Enrique ^a  

^a INSTITUTO DE BIOMEDICINA   (Venezuela)

Author keywords

catenin; Endothelial mesenchymal transition; Growth factors; Intimal thickening; Vascular remodeling

Indexed keywords

ANGIOGENESIS; ATHEROSCLEROSIS; ENDOTHELIUM CELL; MESENCHYMAL STEM CELL; MORPHOGENESIS; REVIEW; TUMOR GROWTH;

EID: 77954412730     PISSN: 18564550     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (47)

1. Hahn C, Schwartz MA. Mechanotransduction in vascular physiology and atherogenesis. Nat Rev 2009; 10: 53-62.
2. Davies PF. Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology. Nat Clin Pract Cardiovasc Med 2009; 6: 16-26.
3. Stewart S, Rassl D. Advances in the understanding and classification of pulmonary hipertension. Histophatology 2009; 54: 104-116.
4. Morrell NW, Adnot S, Archer SL, Dupuis J, Jones PL, MacLean MR et al. Cellular and molecular basis of pulmonary arterial hipertension. J Am Coll Cardiol 2009; 54: S20-S31.
5. Nakashima Y, Xiang Cheng Y, Kinukawa N, Sueishi K. Distributions of diffuse intimai thickening in human arteries: Preferencial expresion in atherosclerosis-prone arteries from an early age. Virchows Arch 2002; 441: 279-88.
6. Nakashima Y, Wight TN, Sueishi K. Early atherosclerosis in humans: Role of diffuse intimai thickening and extracellular matrix proteoglycans. Cardiovasc Res. 2008; 79: 14-23. (Pubitemid 351881944)
7. Majesky MW. Developmental basis of vascular smooth muscle diversity. Arterioscler Thromb Vasc Biol 2007; 27: 1-11.
8. Hoofnagle MH, Thomas JA, Wamboff BR, Owens G. Origin of neointimal smooth muscle: We've come full circle. Arterioscler Thromb Vasc Biol 2006; 26: 2579-2581.
9. Sata M, Saiura A, Kunisato A, Tojo A, Okada S, Tokuhisa T et al. Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis. Nat Med 2002; 8: 403-409. (Pubitemid 34407037)
10. Arciniegas E, Frid MG, Douglas IS, Stenmark KR. Perspectives on endothelial-to-mesenchymal transition: potential contribution to vascular remodeling in chronic pulmonary hipertension. Am J Physiol Lung Cell MoI Physiol 2007; 293: L1-L8.
11. Goumans MJ, van Zonneveld AJ, Dijke PT. Transforming growth factor β-induced endothelial-to-mesenchymal transition: A switch to cardiac fibrosis? Trends Cardiovasc Med 2008; 18: 293-298.
12. Kitao A, Sato Y, Kitamura SS, Harada K, Sasaki M, Morikawa H, et al. Endothelial to mesenchymal transition via transforming growth factor-β1/ smad activation is associated with portal venous stenosis in idiopathic portal hipertension. Am J Pathol 2009; 175: 616-626.
13. Mironov V, Visconti RP, Markwald RR. On the role of shear stress in cardiogenesis. Endothelium 2005; 12: 259-261.
14. Xi-Qiao W, Ying-Kai L, Chun Q, Shu-Liang L. Hyperactivity of fibroblasts and functional regression of endothelial cells contributes to microvessel occlusion in hypertrophic sparring. Microvasc Res 2009; 77: 204-211.
15. Zeisberg EM, Potenta SE, Sugimoto H, Zeisberg M, Kalluri R. Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition. J Am Soc Nephrol 2008; 19: 2282-2287.
16. Potenta S, Zeisberg E, Kalluri R. The role of endothelial-to-mesenchymal transition in cancer progression. British J Cancer 2008; 99: 1375-1379.
17. Baum B, Settleman J, Quinlan MP. Transitions between epithelial and mesenchymal states in development and disease. Seminar Cell Dev Biol 2008; 19: 294-308.
18. Dejana E, Orsenigo F, Lampugnani MG. The role of adherens junctions and VE-cadherin in the control of vascular permeability. J Cell Sci 2008; 121: 2115-2122.
19. Dejana E, Lasserve ET, Weinstein BM. The control of vascular integrity by endothelial cell junctions: Molecular basis and pathological implications. Dev Cell 2009; 16: 209-221
20. Mukherjee S, Tessema M, Wandinger-Ness A. Vesicular trafficking of tyrosine kinase receptors and associated proteins in the regulation of signaling and vascular function. Circ Res 2006; 98: 743-756. (Pubitemid 43755258)
21. Frid MG, Kale VA, Stenmark KR. Mature vascular endothelium can give rise to smooth muscle cells via endothelial mesenchymal transdifferentiation: in vitro analysis. Circ Res 2002; 90; 1189-1196.
22. Liebner S, Catellino A, Gallini R, Rudini N, Iurlaro M, Piccolo S, et al. β-catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse. J Cell Biol 2004; 166: 359-367. (Pubitemid 39031239)
23. Arciniegas E, Neves YC, Carrillo LM. Potential role for insulin-like growth factor II and vitronectin in the endothelial-mesenchymal transition process. Differentiation 2006; 74: 277-292. (Pubitemid 43945780)
24. Arciniegas E, Candelle D. An alternate insulin-like factor I receptor signaling pathway for the progression of endothelial-mesenchymal transition. Bioscience Hypotheses 2008; 1: 312-319.
25. Perks CM, Holly JM. The insulin-like growth factor (IGF) family and breast cancer. Breast Dis 2009; 18: 45-60.
26. Chao W, D' Amore PA. IGF2: Epigenetic regulation and role in development and disease. Cytokine Growth Factor Rev. 2008; 19: 111-120. (Pubitemid 351382280)
27. Zaina S, Nilsson J. Insulin-like growth factor II and its receptors in atherosclerosis and in conditions predisposing to atherosclerosis. Curr Opin Lipidol 2003; 14: 483-489.
28. Hsu E, Feghali-Bostwick, CA. Insulin-like growth factor-II is increased in systemic sclerosis-associated pulmonary fibrosis and contributes to the fibrotic process via Jun N-terminal kinase and phosphatidylinositol-3 kinase dependent pathways. Am J Pathol 2008; 172: 1580-1590. (Pubitemid 351793351)
29. Louvi A, Accili D, Efstratiadis A. Growth promoting interaction of IGF-II with the insulin receptor during mouse embryonic development. Dev Biol 1997; 189: 33-48. (Pubitemid 27402461)
30. Arciniegas E, Carrillo LM, De Sanctis JB, Candelle D. Possible role of NFKB in the embryonic vascular remodeling and the endothelial mesenchymal transition process. Cell Adhesion & Migration 2008; 2: 1-13.
31. Sun HW, Li CJ, Chen, HQ, Lin HL, Lv HX, Zhang M. Involvement of integrins, MAPK and NF-kB in regulation of the shear stress-induced MMP-9 expression in endothelial cells. Biochem Biophys Res Commun 2007; 353: 152-158.
32. Olayioye MA, Neve RM, Lane HA, Hynes NE. The ErbB signaling network: Receptor heterodimerization in development and cancer. EMBO J 2000; 19: 3159-3167.
33. Schneider MR, Wolf E. The epidermal growth factor receptor ligands at a glance. J Cell Physiol 2009; 218: 460-466.
34. Lin SY, Makino K, Xia W, Matin A, Wen Yong, Kwong KY et al. Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat Cell Biol 2001; 3: 802-808. (Pubitemid 32842685)
35. Feigin ME, Muthuswamy SK. ErbB receptors and cell polarity: New pathways and paradigmas for understanding cell migration and invasion. Exp Cell Res 2009; 315: 707-716.
36. De Luca A, Carotenuto A, Rachiglio A, Gallo M, Maiello MR, Aldinucci D, et al. The role of the EGFR signaling in tumor microenvironment. J cell Physiol 2008; 214: 559-567. (Pubitemid 351224199)
37. Ackland ML, Newgreen DF, Fridman M, Watham MC, Arvanitis A, Minichiello J, et al. Epidermal growth factor induced epithelio-mesenchymal transition in human breast carcinoma cells. Lab Invest 2003; 83: 435-448. (Pubitemid 36351005)
38. Beltowski J, Lowicka E. EGF receptor as a drug target in arterial hypertension. Mini Rev Med Chem 2009; 9: 526-538.
39. Sethi G, Ahn KS, Chaturvedi MM, Aggarwal BB. Epidermal growth factor (EGF) activates nuclear factor-kB through IkBα kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IkBα. Oncogene 2007; 26: 7324-7332. (Pubitemid 350115978)
40. Dreux AC, Lamb DJ, Modjtahedi H, Ferns GA. The epidermal growth factor receptors and their family of ligands: Their putative role in atherogenesis. Atherosclerosis 2006; 186: 38-53.
41. Zhang H, Sunnarborg SW, McNaughton K, Johns TG, Lee DC, Faber JE. Heparin-binding epidermal growth factor-like growth factor signaling in flow-induced arterial remodeling. Circ Res 2008; 102: 1275-1285.
42. Camenisch TD, Schroeder JA, Bradley J, Klewer SE, McDonald JA. Heart valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors. Nat Med 2002; 8: 850-855.
43. Anderson-Berry A, O'Brien EA, Bleyl S, Lawson A, Gundersen N, Ryssman D, et al. Vasculogenesis drives pulmonary vascular growth in the developing chick embryo. Dev Dyn 2005; 233: 145-153.
44. Simons M. VEGF and restenosis: The rest of the story. Arterioscler Thromb Vasc Biol. 2009; 29: 439-440.
45. Wu Y, Zhu Z. Vascular endothelial growth factor receptor-I, a therapeutic target in cancer, inflammation and other disorders. Curr Med Chem 2009; 16: 2890-2898.
46. Shay-Salit A, Shushy M, Wolfovitz E, Yahav H, Breviario F, Dejana E, et al. VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells. PNAS 2002; 99: 9462-9467.
47. Yang AD, Camp ER, Fan F, Shen L, Gray MJ, Liu W, et al. Vascular endothelial growth factor receptor-1 activation mediates epithelial to mesenchymal transition in human pancreatic carcinoma cells. Cancer Res 2006; 66: 46-51. (Pubitemid 43166007)