Insulin-like growth factor-II is increased in systemic sclerosis-associated pulmonary fibrosis and contributes to the fibrotic process via jun N-terminal kinase- and phosphatidylinositol-3 kinase-dependent pathways

American Journal of Pathology

Volumn 172, Issue 6, 2008, Pages 1580-1590

  Hsu, Eileen ^a   Feghali Bostwick, Carol A ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; SOMATOMEDIN C; STRESS ACTIVATED PROTEIN KINASE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FEMALE; FIBROBLAST CULTURE; FIBROGENESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG FIBROBLAST; LUNG FIBROSIS; MALE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SYSTEMIC SCLEROSIS;

EID: 44849085143     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.2353/ajpath.2008.071021     Document Type: Article

References (35)

1. Steen VD, Medsger TA: Changes in causes of death in systemic sclerosis, 1972-2002. Ann Rheum Dis 2007, 66:940-944
2. Harrison NK, Cambrey AD, Myers AR, Southcott AM, Black CM, du Bois RM, Laurent GJ, McAnulty RJ: Insulin-like growth factor-I is partially responsible for fibroblast proliferation induced by bronchoalveolar lavage fluid from patients with systemic sclerosis. Clin Sci (Lond) 1994, 86:141-148
3. Homma S, Nagaoka I, Abe H, Takahashi K, Seyama K, Nukiwa T, Kira S: Localization of platelet-derived growth factor and insulin-like growth factor I in the fibrotic lung. Am J Respir Crit Care Med 1995, 152:2084-2089
4. Vanhee D, Gosset P, Wallaert B, Voisin C, Tonnel AB: Mechanisms of fibrosis in coal workers' pneumoconiosis. Increased production of platelet-derived growth factor, insulin-like growth factor type I, and transforming growth factor beta and relationship to disease severity. Am J Respir Crit Care Med 1994, 150:1049-1055
5. Pilewski JM, Liu L, Henry AC, Knauer AV, Feghali-Bostwick CA: Insulin-like growth factor binding proteins 3 and 5 are overexpressed in idiopathic pulmonary fibrosis and contribute to extracellular matrix deposition. Am J Pathol 2005, 166:399-407
6. Yasuoka H, Jukic DM, Zhou Z, Choi AM, Feghali-Bostwick CA: Insulin-like growth factor binding protein 5 induces skin fibrosis: a novel murine model for dermal fibrosis. Arthritis Rheum 2006, 54:3001-3010
7. Yasuoka H, Zhou Z, Pilewski JM, Oury TD, Choi AM, Feghali-Bostwick CA: Insulin-like growth factor-binding protein-5 induces pulmonary fibrosis and triggers mononuclear cellular infiltration. Am J Pathol 2006, 169:1633-1642
8. Silva D, Venihaki M, Guo WH, Lopez MF: Igf2 deficiency results in delayed lung development at the end of gestation. Endocrinology 2006, 147:5584-5591
9. Scott J, Cowell J, Robertson ME, Priestley LM, Wadey R, Hopkins B, Pritchard J, Bell GI, Rall LB, Graham CF, Knott TJ: Insulin-like growth factor-II gene expression in Wilms' tumour and embryonic tissues. Nature 1985, 317:260-262
10. Ghahary A, Tredget EE, Shen Q, Kilani RT, Scott PG, Houle Y: Mannose-6-phosphate/IGF-II receptors mediate the effects of IGF-1-induced latent transforming growth factor beta 1 on expression of type I collagen and collagenase in dermal fibroblasts. Growth Factors 2000, 17:167-176
11. Giani C, Pinchera A, Rasmussen A, Fierabracci P, Bonacci R, Campini D, Bevilacqua G, Trock B, Lippman ME, Cullen KJ: Stromal IGF-II messenger RNA in breast cancer: relationship with progesterone receptor expressed by malignant epithelial cells. J Endocrinol Invest 1998, 21:160-165
12. Morison IM, Becroft DM, Taniguchi T, Woods CG, Reeve AE: Somatic overgrowth associated with overexpression of insulin-like growth factor II. Nat Med 1996, 2:311-316
13. Hetzel M, Bachem M, Anders D, Trischler G, Faehling M: Different effects of growth factors on proliferation and matrix production of normal and fibrotic human lung fibroblasts. Lung 2005, 183:225-237
14. Scarpa RC, Carraway RE, Cochrane DE: Insulin-like growth factor (IGF) induced proliferation of human lung fibroblasts is enhanced by neurotensin. Peptides 2005, 26:2201-2210
15. de Pagter-Holthuizen P, Jansen M, van der Kammen RA, van Schaik FM, Sussenbach JS: Differential expression of the human insulin-like growth factor II gene. Characterization of the IGF-II mRNAs and an mRNA encoding a putative IGF-II-associated protein. Biochim Biophys Acta 1988, 950:282-295
16. Holthuizen P, van der Lee FM, Ikejiri K, Yamamoto M, Sussenbach JS: Identification and initial characterization of a fourth leader exon and promoter of the human IGF-II gene. Biochim Biophys Acta 1990, 1087:341-343
17. de Pagter-Holthuizen P, Jansen M, van Schaik FM, van der Kammen R, Oosterwijk C, Van den Brande JL, Sussenbach JS: The human insulin-like growth factor II gene contains two development-specific promoters. FEBS Lett 1987, 214:259-264
18. Vu TH, Hoffman A: Alterations in the promoter-specific imprinting of the insulin-like growth factor-II gene in Wilms' tumor. J Biol Chem 1996, 271:9014-9023
19. Lu L, Katsaros D, Wiley A, Rigault de la Longrais IA, Puopolo M, Schwartz P, Yu H: Promoter-specific transcription of insulin-like growth factor-II in epithelial ovarian cancer. Gynecol Oncol 2006, 103:990-995
20. Singh P, Dai B, Given RL, Lu X, Holthuizen PE: Differential activation of IGF-II promoters P3 and P4 in Caco-2 cells during growth and differentiation. Gastroenterology 1998, 114:1221-1229
21. Tang SH, Yang DH, Huang W, Zhou M, Zhou HK, Lu XH, Ye G: Differential promoter usage for insulin-like growth factor-II gene in Chinese hepatocellular carcinoma with hepatitis B virus infection. Cancer Detect Prev 2006, 30:192-203
22. Feghali CA, Wright TM: Identification of multiple, differentially expressed messenger RNAs in dermal fibroblasts from patients with systemic sclerosis. Arthritis Rheum 1999, 42:1451-1457
23. Bouros D, Wells AU, Nicholson AG, Colby TV, Polychronopoulos V, Pantelidis P, Haslam PL, Vassilakis DA, Black CM, du Bois RM: Histopathologic subsets of fibrosing alveolitis in patients with systemic sclerosis and their relationship to outcome. Am J Respir Crit Care Med 2002, 165:1581-1586
24. Kim DS, Yoo B, Lee JS, Kim EK, Lim CM, Lee SD, Koh Y, Kim WS, Kim WD, Colby TV, Kitiaichi M: The major histopathologic pattern of pulmonary fibrosis in scleroderma is nonspecific interstitial pneumonia. Sarcoidosis Vasc Diffuse Lung Dis 2002, 19:121-127
25. Pfeilschifter J, Scheidt-Nave C, Leidig-Bruckner G, Woitge HW, Blum WF, Wuster C, Haack D, Ziegler R: Relationship between circulating insulin-like growth factor components and sex hormones in a population-based sample of 50- to 80-year-old men and women. J Clin Endocrinol Metab 1996, 81:2534-2540
26. Ceda GP, Dall'Aglio E, Magnacavallo A, Vargas N, Fontana V, Maggio M, Valenti G, Lee PD, Hintz RL, Hoffman AR: The insulin-like growth factor axis and plasma lipid levels in the elderly. J Clin Endocrinol Metab 1998, 83:499-502
27. Frankel SK, Moats-Staats BM, Cool CD, Wynes MW, Stiles AD, Riches DW: Human insulin-like growth factor-IA expression in transgenic mice promotes adenomatous hyperplasia but not pulmonary fibrosis. Am J Physiol 2005, 288:L805-L812
28. Pandini G, Frasca F, Mineo R, Sciacca L, Vigneri R, Belfiore A: Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved. J Biol Chem 2002, 277:39684-39695
29. Oka Y, Rozek LM, Czech MP: Direct demonstration of rapid insulin-like growth factor II receptor internalization and recycling in rat adipocytes. Insulin stimulates 125I-insulin-like growth factor II degradation by modulating the IGF-II receptor recycling process. J Biol Chem 1985, 260:9435-9442
30. Rolfe KJ, Cambrey AD, Richardson J, Irvine LM, Grobbelaar AO, Linge C: Dermal fibroblasts derived from fetal and postnatal humans exhibit distinct responses to insulin like growth factors. BMC Dev Biol 2007, 7:124
31. Chung KY, Agarwal A, Uitto J, Mauviel A: An AP-1 binding sequence is essential for regulation of the human alpha2(I) collagen (COL1A2) promoter activity by transforming growth factor-beta. J Biol Chem 1996, 271:3272-3278
32. Hocevar BA, Brown TL, Howe PH: TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent Smad4-independent pathway. EMBO J 1999, 18:1345-1356
33. Giannoukakis N, Deal C, Paquette J, Goodyer CG, Polychronakos C: Parental genomic imprinting of the human IGF2 gene. Nat Genet 1993, 4:98-101
34. Vu TH, Hoffman AR: Promoter-specific imprinting of the human insulin-like growth factor-II gene. Nature 1994, 371:714-717
35. Jelinic P, Shaw P: Loss of imprinting and cancer. J Pathol 2007, 211:261-268