Cytokine regulation of intestinal epithelial cell proliferation

Expert Review of Clinical Immunology

Volumn 6, Issue 4, 2010, Pages 531-535

  MacDonald, Thomas T ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

colitis; dkk 1; IFN ; inflammation; TNF ; Wnt signaling

Indexed keywords

CYTOKINE; INTERLEUKIN 13; INTERLEUKIN 5; WNT PROTEIN;

CELL PROLIFERATION; CELL RENEWAL; CROHN DISEASE; ENTERITIS; HOMEOSTASIS; HUMAN; INFLAMMATION; INTESTINE EPITHELIUM CELL; NONHUMAN; NOTE; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SMALL INTESTINE; SMALL INTESTINE MUCOSA; STEM CELL NICHE; ULCERATIVE COLITIS;

EID: 77954407795     PISSN: 1744666X     EISSN: None     Source Type: Journal    
DOI: 10.1586/eci.10.42     Document Type: Note

References (40)

1. Pinto D, Gregorieff A, Begthel H et al. Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev. 17(14), 1709-1713 (2003). (Pubitemid 36870334)
2. Kuhnert F, Davis CR, Wang HT et al. Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1. Proc. Natl Acad. Sci. USA 101(1), 266-271 (2004). (Pubitemid 38084239)
3. Kinzler K W, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 87(2), 159-170 (1996). (Pubitemid 26358996)
4. Fodde R, Smits R, Clevers H. APC, signal transduction and genetic instability in colorectal cancer. Nat. Rev. Cancer 1(1), 55-67 (2001). (Pubitemid 33741881)
5. Holmberg J, Genander M, Halford MM et al. EphB receptors coordinate migration and proliferation in the intestinal stem cell niche. Cell 125(6), 1151-1163 (2006). (Pubitemid 43866196)
6. MacDonald TT. The gut is still the biggest lymphoid organ in the body. Mucosal Immunol. 1, 246-247 (2008).
7. Korzenik JR, Podolsky DK. Evolving knowledge and therapy of infammatory bowel disease. Nat. Rev. Drug Discov. 5(3), 197-209 (2006). (Pubitemid 43336033)
8. Packey CD, Sartor RB. Commensal bacteria, traditional and opportunistic pathogens, dysbiosis and bacterial killing in infammatory bowel diseases. Curr. Opin. Infect. Dis. 22(3), 292-301 (2009).
9. Rovedatti L, Kudo T, Biancheri P et al. Differential regulation of interleukin 17 and interferon g production in infammatory bowel disease. Gut 58(12), 1629-1636 (2009).
10. Monteleone G, Biancone L, Marasco R et al. Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells. Gastroenterology 112(4), 1169-1178 (1997). (Pubitemid 27157528)
11. Monteleone G, Trapasso F, Parrello T et al. Bioactive IL-18 expression is up-regulated in Crohn's disease. J. Immunol. 163(1), 143-147 (1999). (Pubitemid 29295835)
12. Monteleone G, Monteleone I, Fina D et al. Interleukin-21 enhances T-helper cell type I signaling and interferon-g production in Crohn's disease. Gastroenterology 128(3), 687-694 (2005). (Pubitemid 40585371)
13. Fina D, Sarra M, Fantini MC et al. Regulation of gut infammation and th17 cell response by interleukin-21. Gastroenterology 134(4), 1038-1048 (2008). (Pubitemid 351451986)
14. Monteleone G, Caruso R, Fina D et al. Control of matrix metalloproteinase production in human intestinal fbroblasts by interleukin 21. Gut 55(12), 1774-1804 (2006). (Pubitemid 44893577)
15. Caruso R, Fina D, Peluso I et al. A functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3a, by gut epithelial cells. Gastroenterology 132(1), 166-175 (2007). (Pubitemid 46108732)
16. Atreya R, Neurath MF. Signaling molecules: the pathogenic role of the IL-6/STAT-3 trans signaling pathway in intestinal infammation and in colonic cancer. Curr. Drug Targets 9(5), 369-374 (2008). (Pubitemid 352025210)
17. Fuss IJ, Heller F, Boirivant M et al. Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. J. Clin. Invest. 113(10), 1490-1497 (2004). (Pubitemid 39071705)
18. Rutgeerts P, D'Haens G, Hiele M et al. Appendectomy protects against ulcerative colitis. Gastroenterology 106(5), 1251-1253 (1994). (Pubitemid 24129241)
19. Logan RF, Edmond M, Somerville KW et al. Smoking and ulcerative colitis. Br. Med. J. (Clin. Res. Ed.) 288(6419), 751-753 (1984). (Pubitemid 14117953)
20. Franklin WA, McDonald GB, Stein HO et al. Immunohistologic demonstration of abnormal colonic crypt cell kinetics in ulcerative colitis. Hum. Pathol. 16(11), 1129-1132 (1985).
21. Ierardi E, Principi M, Francavilla R et al. Epithelial proliferation and ras p21 oncoprotein expression in rectal mucosa of patients with ulcerative colitis. Dig. Dis. Sci. 46(5), 1083-1087 (2001). (Pubitemid 32375041)
22. Munkholm P. Review article: the incidence and prevalence of colorectal cancer in infammatory bowel disease. Aliment. Pharmacol. Ther. 18(Suppl. 2), 1-5 (2003). (Pubitemid 37174709)
23. Nava P, Koch S, Laukoetter MG et al. Interferon-g regulates intestinal epithelial homeostasis through converging b-catenin signaling pathways. Immunity 32(3), 392-402 (2010).
24. Siegmund B, Fantuzzi G, Rieder F et al. Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-g and TNF-a production. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281(4), R1264-R1273 (2001). (Pubitemid 32948260)
25. Yoshihara K, Yajima T, Kubo C et al. Role of interleukin 15 in colitis induced by dextran sulphate sodium in mice. Gut 55(3), 334-341 (2006). (Pubitemid 43268270)
26. Dieleman LA, Ridwan BU, Tennyson GS et al. Dextran sulfate sodium-induced colitis occurs in severe combined immunodefcient mice. Gastroenterology 107(6), 1643-1652 (1994).
27. Ito R, Shin-Ya M, Kishida T et al. Interferon-g is causatively involved in experimental infammatory bowel disease in mice. Clin. Exp. Immunol. 146(2), 330-338 (2006). (Pubitemid 44581349)
28. Mizoguchi E, Xavier RJ, Reinecker HC et al. Colonic epithelial functional phenotype varies with type and phase of experimental colitis. Gastroenterology 125(1), 148-161 (2003). (Pubitemid 36799116)
29. Vetuschi A, Latella G, Sferra R et al. Increased proliferation and apoptosis of colonic epithelial cells in dextran sulfate sodium-induced colitis in rats. Dig. Dis. Sci. 47(7), 1447-1457 (2002). (Pubitemid 34753919)
30. Wright NA, Pike C, Elia G. Induction of a novel epidermal growth factor-secreting cell lineage by mucosal ulceration in human gastrointestinal stem cells. Nature 343(6253), 82-85 (1990). (Pubitemid 20036360)
31. Higgins LM, Frankel G, Douce G et al. Citrobacter rodentium infection in mice elicits a mucosal Th1 cytokine response and lesions similar to those in murine infammatory bowel disease. Infect. Immun. 67(6), 3031-3039 (1999). (Pubitemid 29244725)
32. Cliffe LJ, Humphreys NE, Lane TE et al. Accelerated intestinal epithelial cell turnover: a new mechanism of parasite expulsion. Science 308(5727), 1463-1465 (2005).
33. Sollid LM. Coeliac disease: dissecting a complex infammatory disorder. Nat. Rev. Immunol. 2(9), 647-655(2002).
34. Wright N, Watson A, Morley A et al. Cell kinetics in fat (avillous) mucosa of the human small intestine. Gut 14(9), 701-710 (1973).
35. Iwamoto M, Koji T, Makiyama K et al. Apoptosis of crypt epithelial cells in ulcerative colitis. J. Pathol. 180(2), 152-159 (1996). (Pubitemid 26370180)
36. Cadigan KM. Wnt-b-catenin signaling. Curr. Biol. 18(20), R943-R947 (2008).
37. Procaccino F, Reinshagen M, Hoffmann P et al. Protective effect of epidermal growth factor in an experimental model of colitis in rats. Gastroenterology 107(1), 12-17 (1994). (Pubitemid 24195340)
38. Greenwood-Van Meerveld B, Venkova K, Connolly K. Effcacy of repifermin (keratinocyte growth factor-2) against abnormalities in gastrointestinal mucosal transport in a murine model of colitis. J. Pharm. Pharmacol. 55(1), 67-75 (2003). (Pubitemid 36142083)
39. Zhao J, de Vera J, Narushima S et al. R-spondin1, a novel intestinotrophic mitogen, ameliorates experimental colitis in mice. Gastroenterology 132(4), 1331-1343 (2007). (Pubitemid 46627581)
40. Reinisch W, de Villiers W, Bene L et al. Fontolizumab in moderate to severe Crohn's disease: a Phase 2, randomized, double-blind, placebo-controlled, multiple-dose study. Infamm. Bowel Dis. 16(2), 233-242 (2010).