메뉴 건너뛰기




Volumn 46, Issue 4, 2010, Pages 235-242

Belatacept in clinical and experimental transplantation - Progress and promise

Author keywords

[No Author keywords available]

Indexed keywords

ABATACEPT; ALEMTUZUMAB; BASILIXIMAB; BELATACEPT; CALCINEURIN INHIBITOR; CD40 LIGAND MONOCLONAL ANTIBODY; CORTICOSTEROID; CYCLOSPORIN A; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD80; MONOCLONAL ANTIBODY CD86; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN; STEROID; TACROLIMUS; UNCLASSIFIED DRUG;

EID: 77954395493     PISSN: 16993993     EISSN: 16994019     Source Type: Journal    
DOI: 10.1358/dot.2010.46.4.1446426     Document Type: Review
Times cited : (5)

References (41)
  • 1
    • 70149090341 scopus 로고    scopus 로고
    • Kidney transplantation in the United States
    • Cecka, J.M. Kidney transplantation in the United States. Clin Transpt 2008, 1-18.
    • (2008) Clin Transpt , pp. 1-18
    • Cecka, J.M.1
  • 3
    • 38149131322 scopus 로고    scopus 로고
    • A randomized, multicenter study of steroid avoidance, early steroid withdrawal or standard steroid therapy in kidney transplant recipients
    • FREEDOM Study Group
    • Vincenti, F., Schena, F.P., Paraskevas, S., Hauser, I.A., Walker, R.G., Grinyo, J. FREEDOM Study Group. A randomized, multicenter study of steroid avoidance, early steroid withdrawal or standard steroid therapy in kidney transplant recipients. Am J Transplant 2008, 8(2): 307-16.
    • (2008) Am J Transplant , vol.8 , Issue.2 , pp. 307-316
    • Vincenti, F.1    Schena, F.P.2    Paraskevas, S.3    Hauser, I.A.4    Walker, R.G.5    Grinyo, J.6
  • 5
    • 38549115640 scopus 로고    scopus 로고
    • Calcineurin inhibitor-sparing regimens in solid organ transplantation: Focus on improving renal function and nephrotoxicity
    • Flechner, S.M., Kobashigawa, J., Klintmalm, G. Calcineurin inhibitor-sparing regimens in solid organ transplantation: focus on improving renal function and nephrotoxicity. Clin Transplant 2008, 22(1): 1-15.
    • (2008) Clin Transplant , vol.22 , Issue.1 , pp. 1-15
    • Flechner, S.M.1    Kobashigawa, J.2    Klintmalm, G.3
  • 6
  • 7
    • 34247582790 scopus 로고    scopus 로고
    • Kidney transplantation with sirolimus and mycophenolate mofetil-based immunosuppression: 5-year results of a randomized prospective trial compared to calcineurin inhibitor drugs
    • Flechner, S.M., Goldfarb, D., Solez, K., et al. Kidney transplantation with sirolimus and mycophenolate mofetil-based immunosuppression: 5-year results of a randomized prospective trial compared to calcineurin inhibitor drugs. Transplantation 2007, 83(7): 883-92.
    • (2007) Transplantation , vol.83 , Issue.7 , pp. 883-892
    • Flechner, S.M.1    Goldfarb, D.2    Solez, K.3
  • 10
    • 34347237615 scopus 로고    scopus 로고
    • Novel Immunosuppression: Small Molecules and Biologics
    • DOI 10.1016/j.semnephrol.2007.03.009, PII S0270929507000642, Renal Transplantation
    • Yabu, J.M., Vincenti, F. Novel immunosuppression: small molecules and biologics. Semin Nephrol 2007, 27(4): 479-86. (Pubitemid 47002072)
    • (2007) Seminars in Nephrology , vol.27 , Issue.4 , pp. 479-486
    • Yabu, J.M.1    Vincenti, F.2
  • 11
    • 10844292763 scopus 로고    scopus 로고
    • Immunosuppressive drugs for kidney transplantation
    • Halloran, P.F. Immunosuppressive drugs for kidney transplantation. N Engl J Med 2004, 351(26): 2715-29.
    • (2004) N Engl J Med , vol.351 , Issue.26 , pp. 2715-2729
    • Halloran, P.F.1
  • 12
    • 51849106466 scopus 로고    scopus 로고
    • What's next in the pipeline
    • Vincenti, F., Kirk, A.D. What's next in the pipeline. Am J Transplant 2008, 8(10): 1972-81.
    • (2008) Am J Transplant , vol.8 , Issue.10 , pp. 1972-1981
    • Vincenti, F.1    Kirk, A.D.2
  • 13
    • 70349110123 scopus 로고    scopus 로고
    • New immunosuppressive protocols with the advent of novel biological drugs
    • Cruzado, J.M., Bestard, O., Grinyó, J.M. New immunosuppressive protocols with the advent of novel biological drugs. Transplantation 2009, 88(3 Suppl): S20-3.
    • (2009) Transplantation , vol.88 , Issue.3 SUPPL.
    • Cruzado, J.M.1    Bestard, O.2    Grinyó, J.M.3
  • 14
    • 0029120245 scopus 로고
    • CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
    • Krummel, M.F., Allison, J.P. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med 1995, 182(2): 459-65.
    • (1995) J Exp Med , vol.182 , Issue.2 , pp. 459-465
    • Krummel, M.F.1    Allison, J.P.2
  • 15
    • 0032543306 scopus 로고    scopus 로고
    • The role of T-cell costimulatory activation pathways in transplant rejection
    • Sayegh, M.H., Turka, L.A. The role of T-cell costimulatory activation pathways in transplant rejection. N Engl J Med 1998, 338(25): 1813-21.
    • (1998) N Engl J Med , vol.338 , Issue.25 , pp. 1813-1821
    • Sayegh, M.H.1    Turka, L.A.2
  • 16
    • 38949173232 scopus 로고    scopus 로고
    • Costimulation blockade in autoimmunity and transplantation
    • Vincenti, F. Costimulation blockade in autoimmunity and transplantation. J Allergy Clin Immunol 2008, 121(2): 299-306.
    • (2008) J Allergy Clin Immunol , vol.121 , Issue.2 , pp. 299-306
    • Vincenti, F.1
  • 17
    • 20044386299 scopus 로고    scopus 로고
    • Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties
    • Larsen, C.P., Pearson, T.C., Adams, A.B. et al. Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties. Am J Transplant 2005, 5(3): 443-53.
    • (2005) Am J Transplant , vol.5 , Issue.3 , pp. 443-453
    • Larsen, C.P.1    Pearson, T.C.2    Adams, A.B.3
  • 18
    • 0029914089 scopus 로고    scopus 로고
    • Covalent dimerization of CD28/CTLA-4 and oligomerization of CD80/CD86 regulate T cell costimulatory interactions
    • Greene, J.L., Leytze, G.M., Emswiler, J., Peach, R., Bajorath, J., Cosand, W., Linsley, P.S. Covalent dimerization of CD28/CTLA-4 and oligomerization of CD80/CD86 regulate T cell costimulatory interactions. J Biol Chem 1996, 271(43): 26762-71.
    • (1996) J Biol Chem , vol.271 , Issue.43 , pp. 26762-26771
    • Greene, J.L.1    Leytze, G.M.2    Emswiler, J.3    Peach, R.4    Bajorath, J.5    Cosand, W.6    Linsley, P.S.7
  • 19
    • 0028675006 scopus 로고
    • Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors
    • Linsley, P.S., Greene, J.L., Brady, W., Bajorath, J., Ledbetter, J.A., Peach, R. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. Immunity 1994, 1(9): 793-801.
    • (1994) Immunity , vol.1 , Issue.9 , pp. 793-801
    • Linsley, P.S.1    Greene, J.L.2    Brady, W.3    Bajorath, J.4    Ledbetter, J.A.5    Peach, R.6
  • 20
    • 65549169583 scopus 로고    scopus 로고
    • Assessment of belatacept-mediated costimulation blockade through evaluation of CD80/86-receptor saturation
    • Latek, R., Fleener, C., Lamian, V. et al. Assessment of belatacept-mediated costimulation blockade through evaluation of CD80/86-receptor saturation. Transplantation 2009, 87(6): 926-33.
    • (2009) Transplantation , vol.87 , Issue.6 , pp. 926-933
    • Latek, R.1    Fleener, C.2    Lamian, V.3
  • 21
    • 0038376148 scopus 로고    scopus 로고
    • Induction of allograft tolerance through costimulatory blockade: First selection of drugs in vitro
    • Vierboom, M.P., Ossevoort, M., Sick, E.A., Haanstra, K., Jonker, M. Induction of allograft tolerance through costimulatory blockade: first selection of drugs in vitro. Transpl Immunol 2003, 11(2): 215-22.
    • (2003) Transpl Immunol , vol.11 , Issue.2 , pp. 215-222
    • Vierboom, M.P.1    Ossevoort, M.2    Sick, E.A.3    Haanstra, K.4    Jonker, M.5
  • 22
    • 0033570195 scopus 로고    scopus 로고
    • Prevention of renal allograft rejection in primates by blocking the B7/CD28 pathway
    • Ossevoort, M.A., Ringers, J., Kuhn, E.M. et al. Prevention of renal allograft rejection in primates by blocking the B7/CD28 pathway. Transplantation 1999, 68(7): 1010-8.
    • (1999) Transplantation , vol.68 , Issue.7 , pp. 1010-1018
    • Ossevoort, M.A.1    Ringers, J.2    Kuhn, E.M.3
  • 24
    • 0036852985 scopus 로고    scopus 로고
    • Combination induction therapy with monoclonal antibodies specific for CD80, CD86, and CD154 in nonhuman primate renal transplantation
    • Montgomery, S.P., Xu, H., Tadaki, D.K. et al. Combination induction therapy with monoclonal antibodies specific for CD80, CD86, and CD154 in nonhuman primate renal transplantation. Transplantation 2002, 74(10): 1365-9.
    • (2002) Transplantation , vol.74 , Issue.10 , pp. 1365-1369
    • Montgomery, S.P.1    Xu, H.2    Tadaki, D.K.3
  • 25
    • 38149028526 scopus 로고    scopus 로고
    • Belatacept and basiliximab diminish human antiporcine xenoreactivity and synergize to inhibit alloimmunity
    • Emamaullee, J.A., Merani, S., Larsen, C.P., Shapiro, A.M. Belatacept and basiliximab diminish human antiporcine xenoreactivity and synergize to inhibit alloimmunity. Transplantation 2008, 85(1): 118-24.
    • (2008) Transplantation , vol.85 , Issue.1 , pp. 118-124
    • Emamaullee, J.A.1    Merani, S.2    Larsen, C.P.3    Shapiro, A.M.4
  • 26
    • 23944502334 scopus 로고    scopus 로고
    • Costimulation blockade with belatacept in renal transplantation
    • Belatacept Study Group
    • Vincenti, F., Larsen, C., Durrbach, A. et al.; Belatacept Study Group. Costimulation blockade with belatacept in renal transplantation. N Engl J Med 2005, 353(8): 770-81.
    • (2005) N Engl J Med , vol.353 , Issue.8 , pp. 770-781
    • Vincenti, F.1    Larsen, C.2    Durrbach, A.3
  • 27
    • 70350129074 scopus 로고    scopus 로고
    • The AJT report: News and issues that affect organ and tissue transplantation. Belatacept results promising.with some caveats
    • Pondrom, S. The AJT report: News and issues that affect organ and tissue transplantation. Belatacept results promising.with some caveats. Am J Transplant 2009, 9(11): 2445-6.
    • (2009) Am J Transplant , vol.9 , Issue.11 , pp. 2445-2446
    • Pondrom, S.1
  • 28
    • 76949101581 scopus 로고    scopus 로고
    • A Phase III Study of Belatacept-based Immunosuppression Regimens versus Cyclosporine in Renal Transplant Recipients (BENEFIT Study)
    • Vincenti, F., Charpentier, B., Vanrenterghem, Y. et al. A Phase III Study of Belatacept-based Immunosuppression Regimens versus Cyclosporine in Renal Transplant Recipients (BENEFIT Study). Am J Transplant 2010, 10(3): 535-46.
    • (2010) Am J Transplant , vol.10 , Issue.3 , pp. 535-546
    • Vincenti, F.1    Charpentier, B.2    Vanrenterghem, Y.3
  • 29
    • 76949090842 scopus 로고    scopus 로고
    • A Phase III Study of Belatacept Versus Cyclosporine in Kidney Transplants from Extended Criteria Donors (BENEFIT-EXT Study)
    • Durrbach, A., Pestana, J.M., Pearson, T. et al. A Phase III Study of Belatacept Versus Cyclosporine in Kidney Transplants from Extended Criteria Donors (BENEFIT-EXT Study). Am J Transplant 2010, 10(3): 547-57.
    • (2010) Am J Transplant , vol.10 , Issue.3 , pp. 547-557
    • Durrbach, A.1    Pestana, J.M.2    Pearson, T.3
  • 30
    • 68949213824 scopus 로고    scopus 로고
    • Mycophenolate pharmacokinetics and pharmacodynamics in belatacept treated renal allograft recipients - A pilot study
    • Bremer, S., Vethe, N.T., Rootwelt, H. et al. Mycophenolate pharmacokinetics and pharmacodynamics in belatacept treated renal allograft recipients - a pilot study. J Transl Med 2009, 7:64.
    • (2009) J Transl Med , vol.7 , pp. 64
    • Bremer, S.1    Vethe, N.T.2    Rootwelt, H.3
  • 31
    • 58849159584 scopus 로고    scopus 로고
    • Belatacept as maintenance immunosuppression for postrenal transplant de novo drug-induced thrombotic microangiopathy
    • Ashman, N., Chapagain, A., Dobbie, H., Raftery, M.J., Sheaff, M.T., Yaqoob, M.M. Belatacept as maintenance immunosuppression for postrenal transplant de novo drug-induced thrombotic microangiopathy. Am J Transplant 2009, 9(2): 424-7.
    • (2009) Am J Transplant , vol.9 , Issue.2 , pp. 424-427
    • Ashman, N.1    Chapagain, A.2    Dobbie, H.3    Raftery, M.J.4    Sheaff, M.T.5    Yaqoob, M.M.6
  • 32
    • 0030966217 scopus 로고    scopus 로고
    • Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement
    • Perez, V.L., Van Parijs, L., Biuckians, A., Zheng, X.X., Strom, T.B., Abbas, A.K. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 1997, 6(4): 411-7. (Pubitemid 27208196)
    • (1997) Immunity , vol.6 , Issue.4 , pp. 411-417
    • Perez, V.L.1    Van Parijs, L.2    Biuckians, A.3    Zheng, X.X.4    Strom, T.B.5    Abbas, A.K.6
  • 33
    • 0030461047 scopus 로고    scopus 로고
    • CD28-B7 T cell costimulatory blockade by CTLA4Ig in the rat renal allograft model: Inhibition of cell-mediated and humoral immune responses in vivo
    • Akalin, E., Chandraker, A., Russell, M.E., Turka, L.A., Hancock, W.W., Sayegh, M.H. CD28-B7 T cell costimulatory blockade by CTLA4Ig in the rat renal allograft model: inhibition of cell-mediated and humoral immune responses in vivo. Transplantation 1996, 62(12): 1942-5.
    • (1996) Transplantation , vol.62 , Issue.12 , pp. 1942-1945
    • Akalin, E.1    Chandraker, A.2    Russell, M.E.3    Turka, L.A.4    Hancock, W.W.5    Sayegh, M.H.6
  • 35
    • 0345713140 scopus 로고    scopus 로고
    • Acute cellular rejection of human renal tissue by adoptive transfer of allogeneic human peripheral blood mononuclear cells into chimeric rats: Sequential gene expression of cytokines, chemokines and cytolytic effector molecules, and their regulation by CTLA-4-Ig
    • Dekel, B., Böcher, W.O., Marcus, H., Yussim, A., Reisner, Y. Acute cellular rejection of human renal tissue by adoptive transfer of allogeneic human peripheral blood mononuclear cells into chimeric rats: sequential gene expression of cytokines, chemokines and cytolytic effector molecules, and their regulation by CTLA-4-Ig. Int Immunol 1999, 11(10): 1673-83.
    • (1999) Int Immunol , vol.11 , Issue.10 , pp. 1673-1683
    • Dekel, B.1    Böcher, W.O.2    Marcus, H.3    Yussim, A.4    Reisner, Y.5
  • 36
    • 0141920662 scopus 로고    scopus 로고
    • Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells
    • Tang, Q., Henriksen, K.J., Boden, E.K. et al. Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells. J Immunol 2003 171(7): 3348-52.
    • (2003) J Immunol , vol.171 , Issue.7 , pp. 3348-3352
    • Tang, Q.1    Henriksen, K.J.2    Boden, E.K.3
  • 37
    • 33746357544 scopus 로고    scopus 로고
    • Regulatory T cells in the periphery
    • Lohr, J., Knoechel, B., Abbas, A.K. Regulatory T cells in the periphery. Immunol Rev 2006, 212: 149-62.
    • (2006) Immunol Rev , vol.212 , pp. 149-162
    • Lohr, J.1    Knoechel, B.2    Abbas, A.K.3
  • 38
    • 51849108540 scopus 로고    scopus 로고
    • The effect of costimulatory and interleukin 2 receptor blockade on regulatory T cells in renal transplantation
    • Bluestone, J.A., Liu, W., Yabu, J.M. et al. The effect of costimulatory and interleukin 2 receptor blockade on regulatory T cells in renal transplantation. Am J Transplant 2008, 8(10): 2086-96.
    • (2008) Am J Transplant , vol.8 , Issue.10 , pp. 2086-2096
    • Bluestone, J.A.1    Liu, W.2    Yabu, J.M.3
  • 39
    • 0042320414 scopus 로고    scopus 로고
    • Memory T cells: A hurdle to immunologic tolerance
    • Lakkis, F.G., Sayegh, M.H. Memory T cells: a hurdle to immunologic tolerance. J Am Soc Nephrol 2003, 14(9): 2402-10.
    • (2003) J Am Soc Nephrol , vol.14 , Issue.9 , pp. 2402-2410
    • Lakkis, F.G.1    Sayegh, M.H.2
  • 40
    • 11144355749 scopus 로고    scopus 로고
    • Homeostatic proliferation is a barrier to transplantation tolerance
    • Wu, Z., Bensinger, S.J., Zhang, J. et al. Homeostatic proliferation is a barrier to transplantation tolerance. Nat Med 2004, 10(1): 87-92.
    • (2004) Nat Med , vol.10 , Issue.1 , pp. 87-92
    • Wu, Z.1    Bensinger, S.J.2    Zhang, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.