Effect of overall charge and charge distribution on cellular uptake, distribution and phototoxicity of cationic porphyrins in HEp2 cells

Journal of Photochemistry and Photobiology B: Biology

Volumn 100, Issue 2, 2010, Pages 100-111

  Jensen, Timothy J ^a   Vicente, M Graça H ^a   Luguya, Raymond ^a   Norton, Jolanna ^a   Fronczek, Frank R ^a   Smith, Kevin M ^a  

^a LOUISIANA STATE UNIVERSITY   (United States)

Author keywords

Cationic porphyrin; Cellular uptake; Cytotoxicity; PDT; Subcellular localization

Indexed keywords

5 (4 N,N,N TRIMETHYLANILINIUM) 10,15,20 TRIPHENYLPORPHYRIN; 5,10 DI(4 N,N,N TRIMETHYLANILINIUM) 15,20 DIPHENYLPORPHYRIN; 5,10,15 TRI(4 N,N,N TRIMETHYLANILINIUM) 20 PHENYLPORPHYRIN; 5,15 DI(4 N,N,N TRIMETHYLANILINIUM) 10,20 DIPHENYLPORPHYRIN; PHOTOSENSITIZING AGENT; PORPHYRIN DERIVATIVE; UNCLASSIFIED DRUG; 5,10,15,20-TETRAPHENYLPORPHYRIN; PHENYLTRIMETHYLAMMONIUM; PORPHYRIN; QUATERNARY AMMONIUM DERIVATIVE;

ARTICLE; CELL COMPARTMENTALIZATION; CELL MEMBRANE; CELL TRANSPORT; CELL VACUOLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACCUMULATION; DRUG CYTOTOXICITY; DRUG DISTRIBUTION; DRUG EFFECT; DRUG UPTAKE; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; HEP 2 CELL; HUMAN; HUMAN CELL; IC 50; LIPID MEMBRANE; MITOCHONDRION; PHOTODYNAMIC THERAPY; PHOTOTOXICITY; PRIORITY JOURNAL; CHEMISTRY; CONFORMATION; FLUORESCENCE MICROSCOPY; SYNTHESIS; TIME; TOXICITY; TUMOR CELL LINE; X RAY CRYSTALLOGRAPHY;

CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; HUMANS; MICROSCOPY, FLUORESCENCE; MOLECULAR CONFORMATION; PHOTOSENSITIZING AGENTS; PORPHYRINS; QUATERNARY AMMONIUM COMPOUNDS; TIME FACTORS;

TETRA;

EID: 77954383970     PISSN: 10111344     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jphotobiol.2010.05.007     Document Type: Article

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