Meso-substituted tetra-cationic porphyrins photosensitize the death of human fibrosarcoma cells via lysosomal targeting

International Journal of Biochemistry and Cell Biology

Volumn 37, Issue 2, 2005, Pages 306-319

  Ricchelli, Fernanda ^a   Franchi, Lisa ^a   Miotto, Giovanni ^a   Borsetto, Lara ^a   Gobbo, Silvano ^a   Nikolov, Peter ^b   Bommer, Jerry C ^c   Reddi, Elena ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b INSTITUTE OF ORGANIC CHEMISTRY   (Bulgaria)

^c Frontier Scientific Inc   (United States)

Author keywords

Fluorescence microscopy; Intracellular localization; Lysosomes; Mitochondria; Tetra cationic porphyrins

Indexed keywords

5,10,15,20 TETRAKIS(4 N METHYLPYRIDYL)PORPHINE; PORPHYRIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL DEATH; CELL ORGANELLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENDOCYTOSIS; FIBROSARCOMA; FLUORESCENCE; HUMAN; HUMAN CELL; LIPOPHILICITY; LYSOSOME; MEMBRANE POTENTIAL; PHOTOSENSITIZATION; RADIATION DOSE;

CATIONS; CELL DEATH; CELL DIVISION; CELL LINE, TUMOR; DRUG DELIVERY SYSTEMS; FIBROSARCOMA; HUMANS; HYDROCARBONS; LYSOSOMES; MITOCHONDRIA; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; PORPHYRINS;

EID: 4944229971     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2004.06.013     Document Type: Article

References (30)

1. S.G. Afonso, R. Enriquez de Salamanca, and A. Batlle Photodynamic and light independent action of 8 to 2 carboxylic free porphyrins on some haem-enzymes International Journal of Biochemistry and Cell Biology 33 2001 1208 1214
2. E. Ben-Hur, S. Rywkin, I. Rosenthal, N.E. Geacintov, and B. Horowitz Virus inactivation in red cell concentrates by photosensitization with phthalocyanines: Protection of red cells but not of vesicular stomatitis virus with a water-soluble analog of Vitamin E Transfusion 35 1995 401 406
3. L.B. Chen Mitochondrial membrane potential in living cells Annual Review of Cell Biology 4 1988 155 181
4. S. Davis, M.J. Weiss, J.R. Wong, T.J. Lampidis, and L.B. Chen Mitochondrial and plasma membrane potentials cause unusual accumulation and retention of rhodamine 123 by human breast adenocarcinoma-derived MCF-7 cells Journal of Biological Chemistry 260 1985 13844 13850
5. T.J. Dougherty, C.J. Gomer, B.W. Henderson, G. Jori, D. Kessel, and M. Korbelik Photodynamic therapy: Review Journal of the National Cancer Institute 90 1998 889 902
6. M. Gze, P. Morlire, J.C. Mazire, K.M. Smith, and R. Santus Lysosomes, a key target of hydrophobic photosensitizers proposed for phototherapeutic applications Journal of Photochemistry and Photobiology B: Biology 20 1993 23 35
7. C.J. Gomer Preclinical examination of first and second generation photosensitizers used in photodynamic therapy Photochemistry and Photobiology 54 1991 1093 1107
8. P. Gonschlor, F. Gerbeuser, M. Fleuchaus, T.Y. Huehns, A.E. Goetz, and U. Welch Local photodynamic therapy reduces tissue hyperplasia in an experimental restenosis model Photochemistry and Photobiology 64 1996 758 763
9. B.W. Henderson, and T.J. Dougherty How does photodynamic therapy work? Photochemistry and Photobiology 55 1992 145 157
10. I.K. Kandela, J.A. Bartlett, and G.L. Indig Effect of molecular structure on the selective phototoxicity of triarylmethane dyes towards tumor cells Photochemical and Photobiological Sciences 1 2002 309 314
11. D. Kessel, Y. Luo, Y. Deng, and C.K. Chang The role of subcellular localization in initiation of apoptosis by photodynamic therapy Photochemistry and Photobiology 65 1997 422 426
12. D. Kessel, and Y. Luo Mitochondrial photodamage and PDT-induced apoptosis Journal of Photochemistry and Photobiology B: Biology 42 1998 89 95
13. D. Kessel, and Y. Luo Photodynamic therapy: A mitochondrial inducer of apoptosis Cell Death and Differentiation 6 1999 28 35
14. A. Leo, C. Hansch, and D. Elkins Partition coefficients and their uses Chemical Reviews 71 1971 525 616
15. I.J. MacDonald, J. Morgan, D.A. Bellnier, G.M. Paszkiewicz, J.E. Whitaker, and D.J. Litchfield Subcellular localization patterns and their relationship to photodynamic activity of pyropheophorbide - A derivatives Photochemistry and Photobiology 70 1999 789 797
16. J. Moan, and K. Berg The photodegradation of porphyrins in cells can be used to estimate the lifetime of singlet oxygen Photochemistry and Photobiology 53 1991 549 553
17. J. Morgan, and A.R. Oseroff Mitochondria-based photodynamic anti-cancer therapy Advanced Drug Delivery Reviews 49 2001 71 86
18. M.F. Nepomuceno, M. Tabak, and A.E. Vercesi Opposite effects of Mn(III) and Fe(III) forms of meso-tetrakis(4-N-methylpyridiniumyl) porphyrins on isolated rat liver mitochondria Journal of Bioenergetics and Biomembranes 34 2002 41 47
19. N.L. Oleinick, R.L. Morris, and I. Belichenko The role of apoptosis in response to photodynamic therapy: What, where, why and how Photochemical and Photobiological Sciences 1 2002 1 21
20. A.R. Oseroff, D. Ohuoha, G. Ara, R.J. McAuliffe, and L. Cincotta Intramitochondrial dyes allow selective in vitro photolysis of carcinoma cells Proceedings of the National Academy of Sciences of the United States of America 83 1986 9729 9733
21. I.A. Patito, C. Rothmann, and Z. Malik Nuclear transport of photosensitizers during photosensitization and oxidative stress Biology of the Cell 93 2001 285 291
22. J.P. Pooler, and D.P. Valenzeno Physicochemical determinants of the sensitising effectiveness for photo oxidation of nerve membranes by fluorescein derivatives Photochemistry and Photobiology 30 1979 491 498
23. C.I. Ragan, M.T. Wilson, V.M. Darley-Usman, and P.N. Lowe Sub-fractionation of mitochondria and isolation of the proteins of oxidative phosphorylation V.M. Darley-Usmar D. Rockwood M.T. Wilson Mitochondria: A practical approach 1987 IRL Press Oxford 79 112
24. E. Reddi, M. Ceccon, G. Valduga, G. Jori, J.C. Bommer, and F. Elisei Photophysical properties and antibacterial activity of meso-substituted cationic porphyrins Photochemistry and Photobiology 75 2002 462 470
25. R.W. Redmond, E.J. Land, and T.G. Truscott Aggregation effects on the photophysical properties of porphyrins in relation to mechanism involved in photodynamic therapy D. Kessel Methods in porphyrin photosensitization 1985 Plenum Press New York 293 302
26. A. Ruck, T. Kollner, A. Dietrich, W. Strauss, and H. Schneckenburger Fluorescence formation during photodynamic therapy in the nucleus of cells incubated with cationic and anionic water-soluble photosensitizers Journal of Photochemistry and Photobiology B: Biology 12 1992 403 412
27. C. Salet, G. Moreno, and F. Vinzens Photodynamic effects induced by furocoumarins on a membrane system Comparison with hematoporphyrin Photochemistry and Photobiology 36 1982 291 296
28. W. Torinuki, T. Miura, and M. Seiji Lysosome destruction and lipoperoxide formation due to active oxygen generated from haematoporphyrin and UV irradiation British Journal of Dermatology 102 1980 17 27
29. K.B. Trauner, and T. Hasan Photodynamic treatment of rheumatoid and inflammatory arthritis Photochemistry and Photobiology 64 1996 740 750
30. K.R. Weishaupt, C.J. Gomer, and T.J. Dougherty Identification of singlet oxygen as the cytotoxic agent in photoinactivation of a murine tumor Cancer Research 36 1976 2326 2329