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Volumn 40, Issue 5, 2010, Pages 449-460

λ-Interferons and the single nucleotide polymorphisms: A milestone to tailor-made therapy for chronic hepatitis C

Author keywords

IL28B; Interferon lambda; Pegylated interferon; Polymorphism; Ribavirin

Indexed keywords

ALPHA INTERFERON; ALPHA2A INTERFERON; BETA INTERFERON; CYTOKINE; GAMMA INTERFERON; INTERFERON; INTERFERON LAMBDA2; INTERFERON LAMBDA3; INTERLEUKIN 10 RECEPTOR 2; INTERLEUKIN 28 RECEPTOR 1; INTERLEUKIN 28A; INTERLEUKIN 28B; INTERLEUKIN 29; PEGINTERFERON ALPHA; PROTEINASE INHIBITOR; RIBAVIRIN; UNCLASSIFIED DRUG;

EID: 77954368611     PISSN: 13866346     EISSN: 1872034X     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2010.00671.x     Document Type: Review
Times cited : (42)

References (46)
  • 1
    • 0036815962 scopus 로고    scopus 로고
    • Global epidemiology and burden of hepatitis C
    • Ray Kim W. Global epidemiology and burden of hepatitis C. Microbes Infect 2002, 4:1219-25.
    • (2002) Microbes Infect , vol.4 , pp. 1219-1225
    • Ray Kim, W.1
  • 2
    • 0035934568 scopus 로고    scopus 로고
    • Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial
    • Manns MP, McHutchison JG, Gordon SC. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001, 358:958-65.
    • (2001) Lancet , vol.358 , pp. 958-965
    • Manns, M.P.1    McHutchison, J.G.2    Gordon, S.C.3    et al4
  • 3
    • 0037179698 scopus 로고    scopus 로고
    • Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection
    • Fried MW, Shiffman ML, Reddy KR. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002, 347:975-82.
    • (2002) N Engl J Med , vol.347 , pp. 975-982
    • Fried, M.W.1    Shiffman, M.L.2    Reddy, K.R.3    et al4
  • 4
    • 1542378867 scopus 로고    scopus 로고
    • Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin dose
    • Hadziyannis SJ, Sette H, Morgan TR. Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin dose. Ann Intern Med 2004, 140:346-55.
    • (2004) Ann Intern Med , vol.140 , pp. 346-355
    • Hadziyannis, S.J.1    Sette, H.2    Morgan, T.R.3    et al4
  • 5
    • 0036830454 scopus 로고    scopus 로고
    • Side effects of therapy of hepatitis C and their management
    • Fried MW. Side effects of therapy of hepatitis C and their management. Hepatology 2002, 36:S237-44.
    • (2002) Hepatology , vol.36
    • Fried, M.W.1
  • 6
    • 4344570256 scopus 로고    scopus 로고
    • Sustained virological response in hepatitis C virus type 1b infected patients is predicted by the number of mutations within the NS5A-ISDR: a meta-analysis focused on geographical differences
    • Pascu M, Martus P, Hohne M. Sustained virological response in hepatitis C virus type 1b infected patients is predicted by the number of mutations within the NS5A-ISDR: a meta-analysis focused on geographical differences. Gut 2004, 53:1345-51.
    • (2004) Gut , vol.53 , pp. 1345-1351
    • Pascu, M.1    Martus, P.2    Hohne, M.3    et al4
  • 7
    • 58149380829 scopus 로고    scopus 로고
    • Pretreatment prediction of virological response to peginterferon plus ribavirin therapy in chronic hepatitis C patients using viral and host factors
    • Shirakawa H, Matsumoto A, Joshita S. Pretreatment prediction of virological response to peginterferon plus ribavirin therapy in chronic hepatitis C patients using viral and host factors. Hepatology 2008, 48:1753-60.
    • (2008) Hepatology , vol.48 , pp. 1753-1760
    • Shirakawa, H.1    Matsumoto, A.2    Joshita, S.3    et al4
  • 8
    • 22344457187 scopus 로고    scopus 로고
    • Association of amino acid substitution pattern in core protein of hepatitis C virus genotype 1b high viral load and non-virological response to interferon-ribavirin combination therapy
    • Akuta N, Suzuki F, Sezaki H. Association of amino acid substitution pattern in core protein of hepatitis C virus genotype 1b high viral load and non-virological response to interferon-ribavirin combination therapy. Intervirology 2005, 48:372-80.
    • (2005) Intervirology , vol.48 , pp. 372-380
    • Akuta, N.1    Suzuki, F.2    Sezaki, H.3    et al4
  • 9
    • 33645114359 scopus 로고    scopus 로고
    • Non-response to antiviral therapy is associated with obesity and increased hepatic expression of suppressor of cytokine signalling 3 (SOCS-3) in patients with chronic hepatitis C, viral genotype 1
    • Walsh MJ, Jonsson JR, Richardson MM. Non-response to antiviral therapy is associated with obesity and increased hepatic expression of suppressor of cytokine signalling 3 (SOCS-3) in patients with chronic hepatitis C, viral genotype 1. Gut 2006, 55:529-35.
    • (2006) Gut , vol.55 , pp. 529-535
    • Walsh, M.J.1    Jonsson, J.R.2    Richardson, M.M.3    et al4
  • 10
    • 1842480410 scopus 로고    scopus 로고
    • Host factors and failure of interferon-alpha treatment in hepatitis C virus
    • Gao B, Hong F, Radaeva S. Host factors and failure of interferon-alpha treatment in hepatitis C virus. Hepatology 2004, 39:880-90.
    • (2004) Hepatology , vol.39 , pp. 880-890
    • Gao, B.1    Hong, F.2    Radaeva, S.3
  • 11
    • 0038071786 scopus 로고    scopus 로고
    • The dinucleotide microsatellite polymorphism of the IFNAR1 gene promoter correlates with responsiveness of hepatitis C patients to interferon
    • Matsuyama N, Mishiro S, Sugimoto M. The dinucleotide microsatellite polymorphism of the IFNAR1 gene promoter correlates with responsiveness of hepatitis C patients to interferon. Hepatol Res 2003, 25:221-5.
    • (2003) Hepatol Res , vol.25 , pp. 221-225
    • Matsuyama, N.1    Mishiro, S.2    Sugimoto, M.3    et al4
  • 12
    • 65349098718 scopus 로고    scopus 로고
    • A polymorphism in MAPKAPK3 affects response to interferon therapy for chronic hepatitis C
    • Tsukada H, Ochi H, Maekawa T. A polymorphism in MAPKAPK3 affects response to interferon therapy for chronic hepatitis C. Gastroenterology 2009
    • (2009) Gastroenterology
    • Tsukada, H.1    Ochi, H.2    Maekawa, T.3    et al4
  • 13
    • 70349548852 scopus 로고    scopus 로고
    • IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy
    • Suppiah V, Moldovan M, Ahlenstiel G. IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. Nat Genet 2009, 41:1100-4.
    • (2009) Nat Genet , vol.41 , pp. 1100-1104
    • Suppiah, V.1    Moldovan, M.2    Ahlenstiel, G.3    et al4
  • 14
    • 42149152139 scopus 로고    scopus 로고
    • An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity
    • Ank N, Iversen MB, Bartholdy C. An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity. J Immunol 2008, 180:2474-85.
    • (2008) J Immunol , vol.180 , pp. 2474-2485
    • Ank, N.1    Iversen, M.B.2    Bartholdy, C.3    et al4
  • 15
    • 70349292099 scopus 로고    scopus 로고
    • Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    • Ge D, Fellay J, Thompson AJ. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 2009, 461:399-401.
    • (2009) Nature , vol.461 , pp. 399-401
    • Ge, D.1    Fellay, J.2    Thompson, A.J.3    et al4
  • 16
    • 70349533037 scopus 로고    scopus 로고
    • Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C
    • Tanaka Y, Nishida N, Sugiyama M. Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. Nat Genet 2009, 41:1105-9.
    • (2009) Nat Genet , vol.41 , pp. 1105-1109
    • Tanaka, Y.1    Nishida, N.2    Sugiyama, M.3    et al4
  • 17
    • 70349966196 scopus 로고    scopus 로고
    • Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
    • Thomas DL, Thio CL, Martin MP. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature 2009, 461:798-801.
    • (2009) Nature , vol.461 , pp. 798-801
    • Thomas, D.L.1    Thio, C.L.2    Martin, M.P.3    et al4
  • 18
    • 68949110201 scopus 로고    scopus 로고
    • Interferon-lambda is functionally an interferon but structurally related to the interleukin-10 family
    • Gad HH, Dellgren C, Hamming OJ, Vends S, Paludan SR, Hartmann R. Interferon-lambda is functionally an interferon but structurally related to the interleukin-10 family. J Biol Chem 2009, 284:20869-75.
    • (2009) J Biol Chem , vol.284 , pp. 20869-20875
    • Gad, H.H.1    Dellgren, C.2    Hamming, O.J.3    Vends, S.4    Paludan, S.R.5    Hartmann, R.6
  • 19
    • 0037236826 scopus 로고    scopus 로고
    • IL-28, IL-29 and their class II cytokine receptor IL-28R
    • Sheppard P, Kindsvogel W, Xu W. IL-28, IL-29 and their class II cytokine receptor IL-28R. Nat Immunol 2003, 4:63-8.
    • (2003) Nat Immunol , vol.4 , pp. 63-68
    • Sheppard, P.1    Kindsvogel, W.2    Xu, W.3    et al4
  • 20
    • 13544263585 scopus 로고    scopus 로고
    • IFN-alpha regulates TLR-dependent gene expression of IFN-alpha, IFN-beta, IL-28, and IL-29
    • Siren J, Pirhonen J, Julkunen I, Matikainen S. IFN-alpha regulates TLR-dependent gene expression of IFN-alpha, IFN-beta, IL-28, and IL-29. J Immunol 2005, 174:1932-7.
    • (2005) J Immunol , vol.174 , pp. 1932-1937
    • Siren, J.1    Pirhonen, J.2    Julkunen, I.3    Matikainen, S.4
  • 21
    • 34147161091 scopus 로고    scopus 로고
    • Viral infections activate types I and III interferon genes through a common mechanism
    • Onoguchi K, Yoneyama M, Takemura A. Viral infections activate types I and III interferon genes through a common mechanism. J Biol Chem 2007, 282:7576-81.
    • (2007) J Biol Chem , vol.282 , pp. 7576-7581
    • Onoguchi, K.1    Yoneyama, M.2    Takemura, A.3    et al4
  • 22
    • 35748976569 scopus 로고    scopus 로고
    • IFN regulatory factor family members differentially regulate the expression of type III IFN (IFN-lambda) genes
    • Osterlund PI, Pietila TE, Veckman V, Kotenko SV, Julkunen I. IFN regulatory factor family members differentially regulate the expression of type III IFN (IFN-lambda) genes. J Immunol 2007, 179:3434-42.
    • (2007) J Immunol , vol.179 , pp. 3434-3442
    • Osterlund, P.I.1    Pietila, T.E.2    Veckman, V.3    Kotenko, S.V.4    Julkunen, I.5
  • 23
    • 42949160129 scopus 로고    scopus 로고
    • IFN-lambda (IFN-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo
    • Sommereyns C, Paul S, Staeheli P, Michiels T. IFN-lambda (IFN-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo. Plos Pathog 2008, 4:e1000017.
    • (2008) Plos Pathog , vol.4
    • Sommereyns, C.1    Paul, S.2    Staeheli, P.3    Michiels, T.4
  • 24
    • 61349086000 scopus 로고    scopus 로고
    • Activation of toll-like receptor-3 induces interferon-lambda expression in human neuronal cells
    • Zhou L, Wang X, Wang YJ. Activation of toll-like receptor-3 induces interferon-lambda expression in human neuronal cells. Neuroscience 2009, 159:629-37.
    • (2009) Neuroscience , vol.159 , pp. 629-637
    • Zhou, L.1    Wang, X.2    Wang, Y.J.3    et al4
  • 25
    • 33644522358 scopus 로고    scopus 로고
    • Inquiring into the differential action of interferons (IFNs): an IFN-alpha2 mutant with enhanced affinity to IFNAR1 is functionally similar to IFN-beta
    • Jaitin DA, Roisman LC, Jaks E. Inquiring into the differential action of interferons (IFNs): an IFN-alpha2 mutant with enhanced affinity to IFNAR1 is functionally similar to IFN-beta. Mol Cell Biol 2006, 26:1888-97.
    • (2006) Mol Cell Biol , vol.26 , pp. 1888-1897
    • Jaitin, D.A.1    Roisman, L.C.2    Jaks, E.3    et al4
  • 26
    • 33846345778 scopus 로고    scopus 로고
    • Differential receptor subunit affinities of type I interferons govern differential signal activation
    • Jaks E, Gavutis M, Uze G, Martal J, Piehler J. Differential receptor subunit affinities of type I interferons govern differential signal activation. J Mol Biol 2007, 366:525-39.
    • (2007) J Mol Biol , vol.366 , pp. 525-539
    • Jaks, E.1    Gavutis, M.2    Uze, G.3    Martal, J.4    Piehler, J.5
  • 27
    • 0037243222 scopus 로고    scopus 로고
    • IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex
    • Kotenko SV, Gallagher G, Baurin VV. IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. Nat Immunol 2003, 4:69-77.
    • (2003) Nat Immunol , vol.4 , pp. 69-77
    • Kotenko, S.V.1    Gallagher, G.2    Baurin, V.V.3    et al4
  • 28
    • 53049101323 scopus 로고    scopus 로고
    • Interferon-lambda contributes to innate immunity of mice against influenza A virus but not against hepatotropic viruses
    • Mordstein M, Kochs G, Dumoutier L. Interferon-lambda contributes to innate immunity of mice against influenza A virus but not against hepatotropic viruses. Plos Pathog 2008, 4:e1000151.
    • (2008) Plos Pathog , vol.4
    • Mordstein, M.1    Kochs, G.2    Dumoutier, L.3    et al4
  • 29
    • 73849130903 scopus 로고    scopus 로고
    • Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines
    • Witte K, Gruetz G, Volk HD. Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines. Genes Immun 2009, 10:702-14.
    • (2009) Genes Immun , vol.10 , pp. 702-714
    • Witte, K.1    Gruetz, G.2    Volk, H.D.3    et al4
  • 30
    • 3442888513 scopus 로고    scopus 로고
    • The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain
    • Donnelly RP, Sheikh F, Kotenko SV, Dickensheets H. The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain. J Leukoc Biol 2004, 76:314-21.
    • (2004) J Leukoc Biol , vol.76 , pp. 314-321
    • Donnelly, R.P.1    Sheikh, F.2    Kotenko, S.V.3    Dickensheets, H.4
  • 31
    • 47249110175 scopus 로고    scopus 로고
    • Association of IL-10 receptor 2 (IL10RB) SNP with systemic sclerosis
    • Hikami K, Ehara Y, Hasegawa M. Association of IL-10 receptor 2 (IL10RB) SNP with systemic sclerosis. Biochem Biophys Res Commun 2008, 373:403-7.
    • (2008) Biochem Biophys Res Commun , vol.373 , pp. 403-407
    • Hikami, K.1    Ehara, Y.2    Hasegawa, M.3    et al4
  • 32
    • 3242672021 scopus 로고    scopus 로고
    • Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1: similarities with type I interferon signaling
    • Dumoutier L, Tounsi A, Michiels T, Sommereyns C, Kotenko SV, Renauld JC. Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1: similarities with type I interferon signaling. J Biol Chem 2004, 279:32269-74.
    • (2004) J Biol Chem , vol.279 , pp. 32269-32274
    • Dumoutier, L.1    Tounsi, A.2    Michiels, T.3    Sommereyns, C.4    Kotenko, S.V.5    Renauld, J.C.6
  • 33
    • 64049087021 scopus 로고    scopus 로고
    • Lambda interferon inhibits human immunodeficiency virus type 1 infection of macrophages
    • Hou W, Wang X, Ye L. Lambda interferon inhibits human immunodeficiency virus type 1 infection of macrophages. J Virol 2009, 83:3834-42.
    • (2009) J Virol , vol.83 , pp. 3834-3842
    • Hou, W.1    Wang, X.2    Ye, L.3    et al4
  • 34
    • 39549094216 scopus 로고    scopus 로고
    • Type III and I interferons increase HIV uptake and replication in human cells that overexpress CD4, CCR5, and CXCR4
    • Serra C, Biolchini A, Mei A, Kotenko S, Dolei A. Type III and I interferons increase HIV uptake and replication in human cells that overexpress CD4, CCR5, and CXCR4. AIDS Res Hum Retroviruses 2008, 24:173-80.
    • (2008) AIDS Res Hum Retroviruses , vol.24 , pp. 173-180
    • Serra, C.1    Biolchini, A.2    Mei, A.3    Kotenko, S.4    Dolei, A.5
  • 35
    • 33646185492 scopus 로고    scopus 로고
    • Lambda interferon (IFN-lambda), a type III IFN, is induced by viruses and IFNs and displays potent antiviral activity against select virus infections in vivo
    • Ank N, West H, Bartholdy C, Eriksson K, Thomsen AR, Paludan SR. Lambda interferon (IFN-lambda), a type III IFN, is induced by viruses and IFNs and displays potent antiviral activity against select virus infections in vivo. J Virol 2006, 80:4501-9.
    • (2006) J Virol , vol.80 , pp. 4501-4509
    • Ank, N.1    West, H.2    Bartholdy, C.3    Eriksson, K.4    Thomsen, A.R.5    Paludan, S.R.6
  • 36
    • 61849126356 scopus 로고    scopus 로고
    • Human interferon-lambda3 is a potent member of the type III interferon family
    • Dellgren C, Gad HH, Hamming OJ, Melchjorsen J, Hartmann R. Human interferon-lambda3 is a potent member of the type III interferon family. Genes Immun 2009, 10:125-31.
    • (2009) Genes Immun , vol.10 , pp. 125-131
    • Dellgren, C.1    Gad, H.H.2    Hamming, O.J.3    Melchjorsen, J.4    Hartmann, R.5
  • 37
    • 21344467289 scopus 로고    scopus 로고
    • Biological activity of interleukins-28 and -29: comparison with type I interferons
    • Meager A, Visvalingam K, Dilger P, Bryan D, Wadhwa M. Biological activity of interleukins-28 and -29: comparison with type I interferons. Cytokine 2005, 31:109-18.
    • (2005) Cytokine , vol.31 , pp. 109-118
    • Meager, A.1    Visvalingam, K.2    Dilger, P.3    Bryan, D.4    Wadhwa, M.5
  • 38
    • 34547729665 scopus 로고    scopus 로고
    • Lundkvist A and Klingstrom J. Lambda interferon (IFN-lambda) in serum is decreased in hantavirus-infected patients, and in vitro-established infection is insensitive to treatment with all IFNs and inhibits IFN-gamma-induced nitric oxide production
    • Stoltz M, Ahlm C. Lundkvist A and Klingstrom J. Lambda interferon (IFN-lambda) in serum is decreased in hantavirus-infected patients, and in vitro-established infection is insensitive to treatment with all IFNs and inhibits IFN-gamma-induced nitric oxide production. J Virol 2007, 81:8685-91.
    • (2007) J Virol , vol.81 , pp. 8685-8691
    • Stoltz, M.1    Ahlm, C.2
  • 39
    • 63149173773 scopus 로고    scopus 로고
    • Differentiated human alveolar type II cells secrete antiviral IL-29 (IFN-lambda 1) in response to influenza A infection
    • Wang J, Oberley-Deegan R, Wang S. Differentiated human alveolar type II cells secrete antiviral IL-29 (IFN-lambda 1) in response to influenza A infection. J Immunol 2009, 182:1296-304.
    • (2009) J Immunol , vol.182 , pp. 1296-1304
    • Wang, J.1    Oberley-Deegan, R.2    Wang, S.3    et al4
  • 40
    • 22544477862 scopus 로고    scopus 로고
    • Gene expression and antiviral activity of alpha/beta interferons and interleukin-29 in virus-infected human myeloid dendritic cells
    • Osterlund P, Veckman V, Siren J. Gene expression and antiviral activity of alpha/beta interferons and interleukin-29 in virus-infected human myeloid dendritic cells. J Virol 2005, 79:9608-17.
    • (2005) J Virol , vol.79 , pp. 9608-9617
    • Osterlund, P.1    Veckman, V.2    Siren, J.3    et al4
  • 41
    • 34248148471 scopus 로고    scopus 로고
    • Effect of interferon-lambda on replication of hepatitis B virus in human hepatoma cells
    • Hong SH, Cho O, Kim K, Shin HJ, Kotenko SV, Park S. Effect of interferon-lambda on replication of hepatitis B virus in human hepatoma cells. Virus Res 2007, 126:245-9.
    • (2007) Virus Res , vol.126 , pp. 245-249
    • Hong, S.H.1    Cho, O.2    Kim, K.3    Shin, H.J.4    Kotenko, S.V.5    Park, S.6
  • 42
    • 33750631014 scopus 로고    scopus 로고
    • Interleukin-29 uses a type 1 interferon-like program to promote antiviral responses in human hepatocytes
    • Doyle SE, Schreckhise H, Khuu-Duong K. Interleukin-29 uses a type 1 interferon-like program to promote antiviral responses in human hepatocytes. Hepatology 2006, 44:896-906.
    • (2006) Hepatology , vol.44 , pp. 896-906
    • Doyle, S.E.1    Schreckhise, H.2    Khuu-Duong, K.3    et al4
  • 43
    • 14744276042 scopus 로고    scopus 로고
    • Lambda interferon inhibits hepatitis B and C virus replication
    • Robek MD, Boyd BS, Chisari FV. Lambda interferon inhibits hepatitis B and C virus replication. J Virol 2005, 79:3851-4.
    • (2005) J Virol , vol.79 , pp. 3851-3854
    • Robek, M.D.1    Boyd, B.S.2    Chisari, F.V.3
  • 44
    • 33845605155 scopus 로고    scopus 로고
    • Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics
    • Marcello T, Grakoui A, Barba-Spaeth G. Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics. Gastroenterology 2006, 131:1887-98.
    • (2006) Gastroenterology , vol.131 , pp. 1887-1898
    • Marcello, T.1    Grakoui, A.2    Barba-Spaeth, G.3    et al4
  • 45
    • 33646265745 scopus 로고    scopus 로고
    • Novel type I interferon IL-28A suppresses hepatitis C viral RNA replication
    • Zhu H, Butera M, Nelson DR, Liu C. Novel type I interferon IL-28A suppresses hepatitis C viral RNA replication. Virol J 2005, 2:80.
    • (2005) Virol J , vol.2 , pp. 80
    • Zhu, H.1    Butera, M.2    Nelson, D.R.3    Liu, C.4
  • 46
    • 20944448432 scopus 로고    scopus 로고
    • SOCS-1 inhibits expression of the antiviral proteins 2',5'-OAS and MxA induced by the novel interferon-lambdas IL-28A and IL-29
    • Brand S, Zitzmann K, Dambacher J. SOCS-1 inhibits expression of the antiviral proteins 2',5'-OAS and MxA induced by the novel interferon-lambdas IL-28A and IL-29. Biochem Biophys Res Commun 2005, 331:543-8.
    • (2005) Biochem Biophys Res Commun , vol.331 , pp. 543-548
    • Brand, S.1    Zitzmann, K.2    Dambacher, J.3    et al4


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