Expression patterns of HLA-DR+ or HLA-DR- on CD4+/CD25++/CD127low regulatory t cells in patients with allergy

Journal of Investigational Allergology and Clinical Immunology

Volumn 20, Issue 3, 2010, Pages 201-209

  Geraldes, Luísa ^a,c   Morgado, J ^b   Almeida, A ^b   Todo Bom, A ^a,c   Santos, P ^b   Paiva, A ^b   Cheira, C ^a   Pais, M L ^b  

^a CENTRO HOSPITALAR E UNIVERSITÁRIO DE COIMBRA   (Portugal)

^b Centro de Histocompatibilidade do Centro Coimbra   (Portugal)

^c Global Allergy and Asthma European Network (GA2LEN)   (Portugal)

Author keywords

Gene expression; Parietaria judaica allergy; Regulatory t cell (treg); Rhinoconjunctivitis

Indexed keywords

CD28 ANTIGEN; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR3; FAS LIGAND; GAMMA INTERFERON; GRANZYME B; HLA DR ANTIGEN; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 7 RECEPTOR; MESSENGER RNA; PROTEIN PRF 1; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ALLERGY; ANTIGEN EXPRESSION; ARTICLE; BASOPHIL; CD4+ CD25+ T LYMPHOCYTE; CELL SELECTION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; EOSINOPHIL COUNT; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HAY FEVER; HUMAN; HUMAN CELL; MALE; PARIETARIA; POLLEN; POLLEN ALLERGY; QUANTITATIVE ANALYSIS; REGULATORY T LYMPHOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; T LYMPHOCYTE ACTIVATION;

ADOLESCENT; ADULT; ANTIGENS, CD4; CONJUNCTIVITIS, ALLERGIC; DNA; FAS LIGAND PROTEIN; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION PROFILING; GRANZYMES; HLA-DR ANTIGENS; HUMANS; IMMUNOGLOBULIN E; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; INTERLEUKIN-7 RECEPTOR ALPHA SUBUNIT; MIDDLE AGED; PARIETARIA; PORE FORMING CYTOTOXIC PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHINITIS, ALLERGIC, SEASONAL; T-LYMPHOCYTES, REGULATORY; YOUNG ADULT;

EID: 77954361996     PISSN: 10189068     EISSN: 16980808     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Thompson PJ. Unique role of allergens and the epithelium in asthma. Clin Exp Allergy. 1998;28:110-6.
2. Akdis M, Verhagen J, Taylor A, Karamloo F, Karagiannidis C, Crameri R, Thunberg S, Deniz G, Valenta R, Fiebig H, Kegel C, Disch R, Schmidt-Weber C, Blaser K, Akdis C. Immune responses in healthy and allergic individuals are characterized by a fi ne balance between allergen-specific T regulatory 1 and T helper 2 cells. J Exp Med. 2004;199:1567-75.
3. Ling EM, Smith T, Nguyen XD, Pridgeon C, Dallman M, Arbery J, Carr V, Robinson D. Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease. Lancet. 2004;363:608-15.
4. Trzonkowski P, Szmit E, Myśliwska J, Myśliwski A. CD4+CD25+ T regulatory cells inhibit cytotoxic activity of CTL and NK cells in humans-impact of immunosenescence. Clin Immunol. 2006;119:307-16.
5. Seroogy CM, Gern JE. The role of T regulatory cells in asthma. J Allergy Clin Immunol. 2005;116:996-9.
6. Chatila TA. Role of regulatory T cells in human diseases. J Allergy Clin Immunol. 2005;116:949-59.
7. Akbari O, Stock P, DeKruyff RH, Umetsu DT. Role of regulatory T cells in allergy and asthma. Curr Opin Immunol. 2003;15:627-33.
8. Grindebacke H, Wing K, Andersson AC, Suri-Payer E, Rak S, Rudin A. Defective suppression of Th2 cytokines by CD4+CD25+ regulatory T cells in birch allergics during birch pollen season. Clin Exp Allergy. 2004;34:1364-72.
9. Crystal-Peters J, Crown WH, Goetzel RZ, Schutt D. The cost of productivity losses associated with allergic rhinitis. Am J Manag Care. 2000;6:373-8.
10. Todo-Bom A, Loureiro C, Almeida MM, Nunes C, Delgado L, Castel-Branco G, Bousquet J. Epidemiology of rhinitis in Portugal: evaluation of the intermittent and persistent types. Allergy. 2007;62:1038-43.
11. Johansson SG, Bieber T, Dahl R, Friedmann P, Lanier B, Lockey R, Motala C, Martell JA, Platts-Mills T, Ring J, Thien F, Cauwenberge PV, Williams HC. Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. J Allergy Clin Immunol. 2004;113:832-6.
12. Behrendt H, BeckerWM.Localization,release and bioavailability of pollen allergens: the influence of environmental factors. Curr Opin Immunol. 2001;13:709-15.
13. D'Amato G, Ruffilli A, Sacerdoti G, Bonini S. Parietaria pollinosis: a review. Allergy. 1992;47:443-9.
14. Colombo P, Bonura A, Costa MA, Izzo V, Passantino R, Locorotondo G, Amoroso S, Geraci D. The allergens of Parietaria. Int Arch Allergy Immunol. 2003;130:173-9.
15. D'Amato G. Urban air pollution and plant-derived respiratory allergy. Clin Exp Allergy. 2000;30:628-36.
16. Cortes L, Carvalho AL, Todo-Bom A, Faro C, Pires E, Verfísimo P. Purification of a novel aminopeptidase from the pollen of Parietaria judaica that alters epithelial integrity and degrades neuropeptides. J Allergy Clin Immunol. 2006;118:878-84.
17. Baecher-Allan C, Wolf E, Hafler A. MHC class II expression identifies functionally distinct human regulatory T cells. J Immunol. 2006;1 76:4622-31.
18. Shevach EM, DiPaolo RA, Andersson J, Zhao DM, Stephens GL, Thornton AM. The lifestlyle of naturally occurring CD4+CD25+Foxp3+ regulatory T cells. Immunol Rev. 2006;212:60-73.
19. Bousquet J, Khaltaev A, Cruz AA, Denburg J, Fokkens WJ, Togias A, Zuberbier T, Baena-Cagnani CE, Canonica GW, van Weel C, Aqache L, Aït-Khaled N, Bachert C, Blaiss MS, Bonini S, Boulet LP, Bousquet PJ, Camargos P, Carlsen KH, Chen Y, Custovic A, Dahl R, Demoly P, Douaqui H, Durham SR, van Wijk RG, Kalavci O, Kaliner MA, Kim YY, Kowalski ML, Kuna P, Le LT, Lemiere C, Li J, Lockey RF, Mavale-Manuel S, Meltzer EO, Mohammad Y, Mullol J, Naclerio R, O'Hehir RE, Ohta K, Ouedraogo S, Palkonen S, Papadopoulos N, Passalacqua G, Pawankar R, Popov TA, Rabe KF, Rosado-Pinto J, Scadding GK, Simons FE, Toskala E, Valovirta E, van Cauwenberge P, Wang DY, Wickman M, Yawn BP, Yorgancioglu A, Yusuf OM, Zar H, Annesi-Maesano I,Bateman ED, Ben Kheder A, Boakye DA, Bouchard J, Burney P, Busse WW, Chan-Yeung M, Chavannes NH, Chuchalin A, Dolen WK, Emuzyte R, Grouse L, Humbert M, Jackson C, Johnston SL, Keith PK, Kemp JP, Klossek JM, Larenas-Linnemann D, Lipworth B, Malo JL, Marshall GD, Naspitz C, Nekam K, Niggemann B, Nizankowska-Mogilnicka E, Okamoto Y, Orru MP, Potter P, Price D, Stoloff SW, Vandenplas O, Viegi G, Williams D. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA2LEN and AllerGen). Allergy. 2008;63:8-160.
20. Global Initiative for Asthma. Global strategy for Asthma Management and Prevention. Washington, DC: National Institutes of Health; National Heart, Lung and Blood Institute, 2002. Updated 2007. Available from: www.ginasthma.com.
21. Vandesompele Jo, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 2002:18;3(7):RESEARCH0034.1-11.
22. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2- ΔΔCT method. Methods. 2001;25:402-8.
23. Bhandoola A, Tai X, Eckhaus M, Auchincloss H, Mason K, Rubin S A, Carbone KM, Grossman Z, Rosenberg AS, Singer A. Peripheral expression of self-MHC-II influences the reactivity and self-tolerance of mature CD4(+) T cells: evidence from a lymphopenic T cell model. Immunity. 2002;17:425-36.
24. high T-regulatory cells in allergic asthma is subjected to TNF-a modulation. Allergy. 2008:63:67-74.
25. Sansom DM, Walker LS. The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T cell biology. Immunol Rev. 2006;212:131-48.
26. Holse M, Assing K, Poulsen LK. CCR3, CCR5, CCR8 and CXCR3 expression in memory T helper cells from allergic rhinitis patients, asymptomatically sensitized and healthy individuals. Clin Mol Allergy. 2006;4:1-6.
27. Okazaki H, Kakurai M, Hirata D, Sato H, Kamimura T, Onai N, Matsushima K, Nakagawa H, Kano S, Minota S. Characterization of chemokine receptor expression and cytokine production in circulating CD4+ T cells from patients with atopic dermatitis: up-regulation of C-C chemokine receptor 4 in atopic dermatitis. Clin Exp Allergy. 2002;32:1236-42.
28. Alam R, Gorska M. Lymphocytes. J Allergy Clin Immunol. 2003;111:S476-85.
29. + regulatory T cells to the paracortical areas of peripheral lymph nodes through high endothelial venules. J Leukoc Biol. 2007;82:1230-8.
30. Romagnani S. Regulation of T cell response. Clin Exp Allergy. 2006;36:1357-66.
31. Voskoboinik I, Smyth MJ, Trapani JA. Perforin-mediated target-cell death and immune homeostasis. Nat Rev Immunol. 2006;6:940-52.
32. Lettau M, Paulsen M, Kabelitz D, Janssen O. Storage, expression and function of Fas ligand, the key death factor of immune cells. Curr Med Chem. 2008;15:1684-96.