The Hpk2-Rrp2 two-component regulatory system of Treponema denticola: A potential regulator of environmental and adaptive responses

Molecular Oral Microbiology

Volumn 25, Issue 4, 2010, Pages 241-251

  Sarkar, J ^a   Frederick, J ^a   Marconi, R T ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

autophosphorylation; Hpk2 Rrp2; PAS domain; phosphotransfer; Treponema denticola; two component regulatory system

Indexed keywords

HPK2 PROTEIN; PROTEIN; PROTEIN HISTIDINE KINASE; RRP2 PROTEIN; UNCLASSIFIED DRUG; BACTERIAL DNA; BACTERIAL PROTEIN; PROTEIN KINASE; PROTEIN-HISTIDINE KINASE; TRANSACTIVATOR PROTEIN;

ADAPTATION; ARTICLE; AUTOPHOSPHORYLATION; BACTERIUM CULTURE; BACTERIUM ISOLATE; CONTROLLED STUDY; DISEASE COURSE; ENVIRONMENTAL FACTOR; GROWTH CURVE; KINETICS; NONHUMAN; OPEN READING FRAME; OPERON; PERIODONTAL DISEASE; PHOSPHATE TRANSPORT; TREPONEMA DENTICOLA; DNA SEQUENCE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MICROBIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PROMOTER REGION; PROTEIN TERTIARY STRUCTURE; REGULATOR GENE;

ADAPTATION, PHYSIOLOGICAL; BACTERIAL PROTEINS; DNA, BACTERIAL; GENE EXPRESSION REGULATION, BACTERIAL; GENES, REGULATOR; OPEN READING FRAMES; OPERON; PERIODONTAL DISEASES; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ANALYSIS, DNA; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TREPONEMA DENTICOLA;

EID: 77954360266     PISSN: 20411006     EISSN: 20411014     Source Type: Journal    
DOI: 10.1111/j.2041-1014.2010.00578.x     Document Type: Article

References (46)

1. Beck, L.L., Smith, T.G. Hoover, T.R. (2007) Look, no hands! Unconventional transcriptional activators in bacteria. Trends Microbiol 15 : 530 537.
2. 54-dependent transcriptional activator of Borrelia burgdorferi, activates rpoS in an enhancer-independent manner. J Bacteriol 191 : 2902 2905.
3. Boardman, B.K., He, M., Ouyang, Z., Xu, H., Pang, X. Yang, X.F. (2008) Essential role of the response regulator Rrp2 in the infectious cycle of Borrelia burgdorferi. Infect Immun 76 : 3844 3853.
4. Burtnick, M.N., Downey, J.S., Brett, P.J. et al. (2007) Insights into the complex regulation of rpoS in Borrelia burgdorferi. Mol Microbiol 65 : 277 293.
5. Caimano, M.J., Iyer, R., Eggers, C.H. et al. (2007) Analysis of the RpoS regulon in Borrelia burgdorferi in response to mammalian host signals provides insight into RpoS function during the enzootic cycle. Mol Microbiol 65 : 1193 1217.
6. Cotter, P.A. Stibitz, S. (2007) c-di-GMP-mediated regulation of virulence and biofilm formation. Curr Opin Microbiol 10 : 17 23.
7. Ellen, R.P. Galimanas, V.B. (2005) Spirochetes at the forefront of periodontal infections. Periodontol 2000 38 : 13 32.
8. Fath, M.J., Mahanty, H.K. Kolter, R. (1989) Characterization of a purF operon mutation which affects colicin V production. J Bacteriol 171 : 3158 3161.
9. Frederick, J.R., Rogers, E.A. Marconi, R.T. (2008) Analysis of a growth-phase-regulated two-component regulatory system in the periodontal pathogen Treponema denticola. J Bacteriol 190 : 6162 6169.
10. Galperin, M.Y. (2004) Bacterial signal transduction network in a genomic perspective. Environ Microbiol 6 : 552 567.
11. Galperin, M.Y. (2006) Structural classification of bacterial response regulators: diversity of output domains and domain combinations. J Bacteriol 188 : 4169 4182.
12. Galperin, M.Y., Nikolskaya, A.N. Koonin, E.V. (2001) Novel domains of the prokaryotic two-component signal transduction systems. FEMS Microbiol Lett 203 : 11 21.
13. Haffajee, A.D. Socransky, S.S. (2005) Microbiology of periodontal diseases: introduction. Periodontol 2000 38 : 9 12.
14. Hager, J., Staker, B.L., Bugl, H. Jakob, U. (2002) Active site in RrmJ, a heat shock-induced methyltransferase. J Biol Chem 277 : 41978 41986.
15. Handfield, M., Baker, H.V. Lamont, R.J. (2008) Beyond good and evil in the oral cavity: insights into host-microbe relationships derived from transcriptional profiling of gingival cells. J Dent Res 87 : 203 223.
16. Kolenbrander, P.E., Andersen, R.N., Blehert, D.S., Egland, P.G., Foster, J.S. Palmer, R.J. Jr. (2002) Communication among oral bacteria. Microbiol Mol Biol Rev 66 : 486 505.
17. Kolenbrander, P.E., Palmer, R.J. Jr., Rickard, A.H., Jakubovics, N.S., Chalmers, N.I. Diaz, P.I. (2006) Bacterial interactions and successions during plaque development. Periodontol 2000 42 : 47 79.
18. Koretke, K.K., Lupas, A.N., Warren, P.V., Rosenberg, M. Brown, J.R. (2000) Evolution of two-component signal transduction. Mol Biol Evol 17 : 1956 1970.
19. Loesche, W.J. (1988) The role of spirochetes in periodontal disease. Adv Dent Res 2 : 275 283.
20. Loesche, W.J. Grossman, N.S. (2001) Periodontal disease as a specific, albeit chronic, infection: diagnosis and treatment. Clin Microbiol Rev 14 : 727 752.
21. Lybecker, M.C. Samuels, D.S. (2007) Temperature-induced regulation of RpoS by a small RNA in Borrelia burgdorferi. Mol Microbiol 64 : 1075 1089.
22. McDowell, J.V., Frederick, J., Stamm, L. Marconi, R.T. (2007) Identification of the gene encoding the FhbB protein of Treponema denticola, a highly unique factor H-like protein 1 binding protein. Infect Immun 75 : 1050 1054.
23. McDowell, J.V., Huang, B., Fenno, J.C. Marconi, R.T. (2009) Analysis of a unique interaction between the complement regulatory protein factor H and the periodontal pathogen Treponema denticola. Infect Immun 77 : 1417 1425.
24. McEvoy, M.M., Hausrath, A.C., Randolph, G.B., Remington, S.J. Dahlquist, F.W. (1998) Two binding modes reveal flexibility in kinase/response regulator interactions in the bacterial chemotaxis pathway. Proc Natl Acad Sci U S A 95 : 7333 7338.
25. Moglich, A., Ayers, R.A. Moffat, K. (2009) Structure and signaling mechanism of Per-ARNT-Sim domains. Structure 17 : 1282 1294.
26. Mohammadi, T., Karczmarek, A., Crouvoisier, M., Bouhss, A., Mengin-Lecreulx, D. den Blaauwen, T. (2007) The essential peptidoglycan glycosyltransferase MurG forms a complex with proteins involved in lateral envelope growth as well as with proteins involved in cell division in Escherichia coli. Mol Microbiol 65 : 1106 1121.
27. Morozova, O.V., Dubytska, L.P., Ivanova, L.B. et al. (2005) Genetic and physiological characterization of 23S rRNA and ftsJ mutants of Borrelia burgdorferi isolated by mariner transposition. Gene 357 : 63 72.
28. Ohta, N. Newton, A. (2003) The core dimerization domains of histidine kinases contain recognition specificity for the cognate response regulator. J Bacteriol 185 : 4424 4431.
29. Ouyang, Z., Blevins, J.S. Norgard, M.V. (2008) Transcriptional interplay among the regulators Rrp2, RpoN and RpoS in Borrelia burgdorferi. Microbiology 154 : 2641 2658.
30. Paster, B.J., Boches, S.K., Galvin, J.L. et al. (2001) Bacterial diversity in human subgingival plaque. J Bacteriol 183 : 3770 3783.
31. Paster, B.J., Olsen, I., Aas, J.A. Dewhirst, F.E. (2006) The breadth of bacterial diversity in the human periodontal pocket and other oral sites. Periodontol 2000 42 : 80 87.
32. Rogers, E.A., Terekhova, D., Zhang, H.M., Hovis, K.M., Schwartz, I. Marconi, R.T. (2009) Rrp1, a cyclic-di-GMP-producing response regulator, is an important regulator of Borrelia burgdorferi core cellular functions. Mol Microbiol 71 : 1551 1573.
33. Scholten, M. Tommassen, J. (1993) Topology of the PhoR protein of Escherichia coli and functional analysis of internal deletion mutants. Mol Microbiol 8 : 269 275.
34. Seshadri, R., Myers, G.S.A., Tettelin, H. et al. (2004) Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes. Proc Natl Acad Sci U S A 101 : 5646 5651.
35. Simionato, M.R., Tucker, C.M., Kuboniwa, M. et al. (2006) Porphyromonas gingivalis genes involved in community development with Streptococcus gordonii. Infect Immun 74 : 6419 6428.
36. Smith, K.D., Lipchock, S.V., Ames, T.D., Wang, J., Breaker, R.R. Strobel, S.A. (2009) Structural basis of ligand binding by a c-di-GMP riboswitch. Nat Struct Mol Biol 16 : 1218 1223.
37. Socransky, S.S. Haffajee, A.D. (2005) Periodontal microbial ecology. Periodontol 2000 38 : 135 187.
38. Stock, A.M. (2007) Diguanylate cyclase activation: it takes two. Structure 15 : 887 888.
39. Stock, A.M., Robinson, V.L. Goudreau, P.N. (2000) Two-component signal transduction. Annu Rev Biochem 69 : 183 215.
40. Taylor, B.L. Zhulin, I.B. (1999) PAS domains: internal sensors of oxygen, redox potential, and light. Microbiol Mol Biol Rev 63 : 479 506.
41. Wright, J.S. 3rd. Kadner, R.J. (2001) The phosphoryl transfer domain of UhpB interacts with the response regulator UhpA. J Bacteriol 183 : 3149 3159.
42. Yamada, M., Makino, K., Shinagawa, H. Nakata, A. (1990) Regulation of the phosphate regulon of Escherichia coli: properties of phoR deletion mutants and subcellular localization of PhoR protein. Mol Gen Genet 220 : 366 372.
43. Yang, X.F., Alani, S.M. Norgard, M.V. (2003) The response regulator Rrp2 is essential for the expression of major membrane lipoproteins in Borrelia burgdorferi. Proc Natl Acad Sci U S A 100 : 11001 11006.
44. Zhang, N., Chen, X., Li, M. et al. (2004a) Solution structure of BmKK4, the first member of subfamily alpha-KTx 17 of scorpion toxins. Biochemistry 43 : 12469 12476.
45. Zhang, N., Wu, G., Wu, H., Chalmers, M.J. Gaskell, S.J. (2004b) Purification, characterization and sequence determination of BmKK4, a novel potassium channel blocker from Chinese scorpion Buthus martensi Karsch. Peptides 25 : 951 957. (Pubitemid 38760282)
46. Zhang, H., Raji, A., Theisen, M., Hansen, P.R. Marconi, R.T. (2005) bdrF2 of Lyme disease spirochetes is coexpressed with a series of cytoplasmic proteins and is produced specifically during early infection. J Bacteriol 187 : 175 184.