Effects of 1-O-hexyl-2,3,5-trimethylhydroquinone on carbon tetrachloride-induced hepatic cirrhosis in rats

Hepatology Research

Volumn 40, Issue 6, 2010, Pages 613-621

  An, Jun ^a   Feng, Guo Gang ^a   Huang, Lei ^a   Kurokawa, Tsuyoshi ^a   Nonami, Toshiaki ^a   Koide, Tatsuro ^b   Kondo, Fumio ^a   Komatsu, Toru ^a   Tsunekawa, Koji ^a   Fujiwara, Yoshihiro ^a   Goto, Hidemi ^c   Nishikawa, Hiroshi ^d   Miki, Tokutaro ^d   Sugiyama, Satoru ^a   Ishikawa, Naohisa ^a  

^a AICHI MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b AICHI GAKUIN UNIVERSITY   (Japan)

^c NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d Nippon Hypox Laboratories   (Japan)

Author keywords

1 O hexyl 2; 3; 5 trimethylhydroquinone; Fibrosis; Inducible nitric oxide synthase; Interleukin 1 ; Transforming growth factor 1

Indexed keywords

EID: 77954359136     PISSN: 13866346     EISSN: 1872034X     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2010.00638.x     Document Type: Article

References (25)

1. Tacke F, Luedde T, Trautwein C. Inflammatory pathways in liver homeostasis and liver injury. Clin Rev Allergy Immunol 2009, 36:4-12.
2. Gieling RG, Wallace K, Han YP. Interleukin-1 participates in the progression from liver injury to fibrosis. Am J Physiol Gastrointest Liver Physiol 2009, 296:G1324-31.
3. Andus T, Bauer J, Gerok W. Effects of cytokines on the liver. Hepatology 1991, 13:364-75.
4. Mancini R, Benedetti A, Jezequel AM. An interleukin-1 receptor antagonist decreases fibrosis induced by dimethylnitrosamine in rat liver. Virchows Arch 1994, 424:25-31.
5. Hanada T, Yoshimura A. Regulation of cytokine signaling and inflammation. Cytokine Growth Factor Rev 2002, 13:413-21.
6. Llorent L, Richaud-Patin Y, Alcocer-Castillejos N. Cytokine gene expression in cirrhotic and non-cirrhotic human liver. J Hepatol 1996, 24:555-63.
7. Geller DA, de Vera ME, Russell DA. A central role for IL-1 beta in the in vitro and in vivo regulation of hepatic inducible nitric oxide synthase. IL-1 beta induces hepatic nitric oxide synthesis. J Immunol 1995, 155:4890-8.
8. Kitade H, Sakitani K, Inoue K. Interleukin 1 beta markedly stimulates nitric oxide formation in the absence of other cytokines or lipopolysaccharide in primary cultured rat hepatocytes but not in Kupffer cells. Hepatocyte 1996, 23:797-802.
9. Novitskiy G, Potter JJ, Wang L, Mezey E. Influences of reactive oxygen species and nitric oxide on hepatic fibrogenesis. Liver Int 2006, 26:1248-57.
10. Hino T, Kawanishi S, Yasui H, Oka S, Sakurai H. HTHQ (1-O-hexyl-2,3,5-trimethylhydroquinone), an anti-lipid-peroxidative compound: its chemical and biochemical characterizations. Biochim Biophys Acta 1998, 1425:47-60.
11. Liu W, Itoigawa M, Miki T, Nishikawa H, Sugiyama S, Ishikawa N. 1-O-hexyl-2,3,5-trimethylhydroquinone inhibits IkappaB phosphorylation and degradation-linked inducible nitric oxide synthase expression: beyond antioxidant function. J Pharm Pharmacol 2002, 54:383-9.
12. Houglum K, Brenner DA, Chojkier M. d-alpha-tocopherol inhibits collagen alpha 1 (I) gene expression in cultured human fibroblasts. Modulation of constitutive collagen gene expression by lipid peroxidation. J Clin Invest 1991, 87:2230-5.
13. Chojkier M, Houglum K, Lee KS, Buck M. Long- and short-term d-alpha-tocopherol supplementation inhibits liver collagen alpha1 (I) gene expression. Am J Physiol 1998, 275:G1480-5.
14. Aram G, Potter JJ, Liu X, Torbenson MS, Mezey E. Lack of inducible nitric oxide synthase leads to increased hepatic apoptosis and decreased fibrosis in mice after chronic carbon tetrachloride administration. Hepatology 2008, 47:2051-8.
15. An J, Tsunekawa K, Feng GG. Roles of naofen, a novel WD-repeat-2 protein, in the CCl4-treated livers - a possible relationship to cell proliferation. Eur J Pharmacol 2008, 587:285-90.
16. Stegemann H, Stalder K. Determination of hydroxyproline. Clin Chim Acta 1967, 18:267-73.
17. Murawaki Y, Hirayama C. Hepatic collagenolytic cathepsin in patients with chronic liver disease. Clin Chim Acta 1980, 108:121-8.
18. Feng GG, Yamada M, Wongsawatkul O. Role of naofen, a novel WD repeat-containing protein, in reducing nitric oxide-induced relaxation. Clin Exp Pharmacol Physiol 2008, 35:1447-53.
19. Seglen PO. Preparation of isolated rat liver cells. Methods Cell Biol 1976, 13:29-83.
20. Parola M, Leonarduzzi G, Biasi F. Vitamin E dietary supplementation protects against carbon tetrachloride-induced chronic liver damage and cirrhosis. Hepatology 1992, 16:1014-21.
21. Parola M, Muraca R, Dianzani I. Vitamin E dietary supplementation inhibits transforming growth factor beta 1 gene expression in the rat liver. FEBS Lett 1992, 308:267-70.
22. James LP, Mayeux PR, Hinson JA. Acetaminophen-induced hepatotoxicity. Drug Metab Dispos 2003, 31:1499-506.
23. Bataller R, Brenner DA. Liver fibrosis. J Clin Invest 2005, 115:209-18.
24. Kawada N, Kuroki T, Uoya M, Inoue M, Kobayashi K. Smooth muscle alpha-actin expression in rat hepatic stellate cell is regulated by nitric oxide and cGMP production. Biochem Biophys Res Commun 1996, 229:238-42.
25. Pan X, Wang X, Lei W. Nitric oxide suppresses transforming growth factor-beta1-induced epithelial-to-mesenchymal transition and apoptosis in mouse hepatocytes. Hepatology 2009, 50:1577-87.