Expression profile of RhoGDI2 in lung cancers and role of RhoGDI2 in lung cancer metastasis

Oncology Reports

Volumn 24, Issue 2, 2010, Pages 465-471

  Niu, Huiyan ^a   Li, Hui ^a   Xu, Can ^a   He, Ping ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Invasion; Lung cancer; Metastasis; PI3K Akt mTOR signalling pathway; Rho GDP dissociation inhibitor 2

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RHO GDP DISSOCIATION INHIBITOR; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; ARHGDIB PROTEIN, HUMAN; GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR; RHO GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR; RHO GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR 2; SMALL INTERFERING RNA; TUMOR SUPPRESSOR PROTEIN;

ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CANCER TISSUE; CARCINOGENESIS; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; LUNG CANCER; LUNG METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; CANCER STAGING; CARCINOMA; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; LUNG TUMOR; METASTASIS; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA; CELL LINE, TUMOR; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; GUANINE NUCLEOTIDE DISSOCIATION INHIBITORS; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM METASTASIS; NEOPLASM STAGING; RHO GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR BETA; RHO-SPECIFIC GUANINE NUCLEOTIDE DISSOCIATION INHIBITORS; RNA, SMALL INTERFERING; TUMOR SUPPRESSOR PROTEINS;

EID: 77954356790     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000880     Document Type: Article

References (23)

1. Hirsch FR, Franklin WA, Gazdar AF and Bunn PA Jr: Early detection of lung cancer: Clinical perspectives of recent advances in biology and radiology. Clin Cancer Res 7: 5-22, 2001.
2. Stafford LJ, Vaidya KS and Welch DR: Metastasis suppressors genes in cancer. Int J Biochem Cell Biol 40: 874-891, 2008.
3. Gildea JJ, Seraj MJ, Oxford G, et al: RhoGDI2 is an invasion and metastasis suppressor gene in human cancer. Cancer Res 62: 6418-6423, 2002. (Pubitemid 35364098)
4. Scherle P, Behrens T and Staudt LM: Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes. Proc Natl Acad Sci USA 90: 7568-7572, 1993. (Pubitemid 23249991)
5. Titus B, Frierson HF Jr, Conaway M, et al: Endothelin axis is a target of the lung metastasis suppressor gene RhoGDI2. Cancer Res 65: 7320-7327, 2005.
6. Theodorescu D, Sapinoso LM, Conaway MR, Oxford G, Hampton GM and Frierson HF Jr: Reduced expression of metastasis suppressor RhoGDI2 is associated with decreased survival for patients with bladder cancer. Clin Cancer Res 10: 3800-3806, 2004.
7. Ma L, Xu G, Sotnikova A, et al: Loss of expression of LyGDI (ARHGDIB), a rho GDP-dissociation inhibitor, in Hodgkin lymphoma. Br J Haematol 139: 217-223, 2007.
8. Cho HJ, Baek KE, Park SM, et al: RhoGDI2 expression is associated with tumor growth and malignant progression of gastric cancer. Clin Cancer Res 15: 2612-2619, 2009.
9. Tapper J, Kettunen E, El-Rifai W, Seppala M, Andersson LC and Knuutila S: Changes in gene expression during progression of ovarian carcinoma. Cancer Genet Cytogenet 128: 1-6, 2001.
10. Zhang Y and Zhang B: D4-GDI, a Rho GTPase regulator, promotes breast cancer cell invasiveness. Cancer Res 66: 5592-5598, 2006.
11. Brighton PJ, Szekeres PG and Willars GB: Neuromedin U and its receptors: structure, function, and physiological roles. Pharmacol Rev 56: 231-248, 2004.
12. Nelson J, Bagnato A, Battistini B and Nisen P: The endothelin axis: Emerging role in cancer. Nat Rev Cancer 3: 110-116, 2003.
13. Moissoglu K, McRoberts KS, Meier JA, Theodorescu D and Schwartz MA: Rho GDP dissociation inhibitor 2 suppresses metastasis via unconventional regulation of RhoGTPases. Cancer Res 69: 2838-2844, 2009.
14. Wu Y, Moissoglu K, Wang H, et al: Src phosphorylation of RhoGDI2 regulates its metastasis suppressor function. Proc Natl Acad Sci USA 106: 5807-5812, 2009.
15. Cantley LC: The phosphoinositide 3-kinase pathway. Science 296: 1655-1657, 2002.
16. Manning BD and Cantley LC: Akt/pkb signaling: Navigating downstream. Cell 129: 1261-1274, 2007.
17. Shimizu M, Saitoh Y and Itoh H: Immunohistochemical staining of Ha-ras oncogene product in normal, benign, and malignant human pancreatic tissues. Hum Pathol 21: 607-612, 1990.
18. Zhang Y, Rivera Rosado LA, Moon SY and Zhang B: Silencing of D4-GDI inhibits growth and invasive behavior in MDA-MB-231 cells by activation of Rac-dependent p38 and JNK signaling. J Biol Chem 284: 12956-12965, 2009.
19. Tang JM, He QY, Guo RX and Chang XJ: Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis. Lung Cancer 51: 181-191, 2006.
20. Chun KH, Kosmeder JW II, Sun S, et al: Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells. J Natl Cancer Inst 95: 291-302, 2003.
21. Sos ML, Fischer S, Ullrich R, et al: Identifying genotype-dependent efficacy of single and combined PI3K- and MAPKpathway inhibition in cancer. Proc Natl Acad Sci USA 106: 18351-18356, 2009.
22. Sarbassov DD, Guertin DA, Ali SM and Sabatini DM: Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307: 1098-1101, 2005.
23. O'Reilly KE, Rojo F, She QB, et al: mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res 66: 1500-1508, 2006.