Pattern of expression of inflammatory markers in adipose tissue of untreated hypertensive patients

Journal of Hypertension

Volumn 28, Issue 7, 2010, Pages 1459-1465

  Madec, Stephanie ^a   Chiarugi, Massimo ^a   Santini, Eleonora ^a   Rossi, Chiara ^a   Miccoli, Paolo ^a   Ferrannini, Ele ^a   Solini, Anna ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

adipocyte; cytokine; inflammation; metalloproteases; visceral fat

Indexed keywords

GELATINASE A; GELATINASE B; INTERLEUKIN 6; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ABDOMINAL FAT; ADIPOSE TISSUE; ADULT; ARTICLE; CARDIOVASCULAR FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; HYPERTENSION; INFLAMMATION; MALE; MEASUREMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUBCUTANEOUS FAT;

EID: 77954351274     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/HJH.0b013e3283388871     Document Type: Article

References (27)

1. Thalmann S, Meier CA. Local adipose tissue depots as cardiovascular risk factors. Cardiovasc Res 2007; 75:690-701.
2. Bray GA. Medical consequences of obesity. J Clin Endocrinol Metab 2004; 89:2583-2589.
3. Ahima RS. Adipose tissue as an endocrine organ. Obesity (Silver Spring) 2006; 14 (Suppl 5):242S-249S.
4. Greenberg AS, Obin MS. Obesity and the role of adipose tissue in inflammation and metabolism. Am J Clin Nutr 2006; 83:461S-465S.
5. Hutley L, Prins JB. Fat as an endocrine organ: relationship to the metabolic syndrome. Am J Med Sci 2005; 330:280-289.
6. Bouloumie A, Sengenes C, Portolan G, Galitzky J, Lafontan M. Adipocyte produces matrix met alloproteinases 2 and 9: involvement in adipose differentiation. Diabetes 2001; 50:2080-2086.
7. Maquoi E, Munaut C, Colige A, Collen D, Lijnen HR. Modulation of adipose tissue expression of murine matrix met alloproteinases and their tissue inhibitors with obesity. Diabetes 2002; 51:1093-1101.
8. Hall MC, Young DA, Waters JG, Rowan AD, Chantry A, Edwards DR, Clark IM. The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-beta 1. J Biol Chem 2003; 278:10304-10313.
9. Naya M, Tsukamoto T, Morita K, Katoh C, Furumoto T, Fujii S, et al. Plasma interleukin-6 and tumor necrosis factor-alpha can predict coronary endothelial dysfunction in hypertensive patients. Hypertens Res 2007; 30:541-548.
10. Gustafson B, Hammarstedt A, Andersson CX, Smith U. Inflamed adipose tissue: a culprit underlying the metabolic syndrome and atherosclerosis. Arterioscler Thromb Vasc Biol 2007; 27:2276-2283.
11. Nieto-Vazquez I, Fernández-Veledo S, de Alvaro C, Lorenzo M. Dual role of interleukin-6 in regulating insulin sensitivity in murine skelet al muscle. Diabetes 2008; 57:3211-3221.
12. Rodbell M. Localization of lipoprotein lipase in fat cells of rat adipose tissue. J Biol Chem 1964; 239:753-755.
13. Berg AH. Scherer PE Adipose tissue, inflammation, and cardiovascular disease. Circ Res 2005; 96:939-949.
14. Sironi AM, Pingitore A, Ghione S, De Marchi D, Scattini B, Positano V, et al. Early hypertension is associated with reduced regional cardiac function, insulin resistance, epicardial, and visceral fat. Hypertension 2008; 51:282-288.
15. Franckhauser S, Elias I, Rotter Sopasakis V, Ferré T, Nagaev I, Andersson CX, et al. Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice. Diabetologia 2008; 51:1306-1316.
16. Coles B, Fielding CA, Rose-John S, Scheller J, Jones SA, O'Donnell VB. Classic interleukin-6 receptor signaling and interleukin-6 trans-signaling differentially control angiotensin II-dependent hypertension, cardiac signal transducer and activator of transcription-3 activation, and vascular hypertrophy in vivo. Am J Pathol 2007; 171:315-325.
17. Faber DR, de Groot PG, Visseren FL. Role of adipose tissue in haemostasis, coagulation and fibrinolysis. Obes Rev 2009; 10:554-563.
18. Armas-Hernández MJ, Hernández-Hernández R, Armas-Padilla MC, Sosa-Canache B, Cammarata R, Pacheco B, et al. Fibrinolytic system in normotensive subjects and hypertensive patients. Am J Ther 2007; 14:177-182.
19. Navarro-Gonzales JF, Muros M, Jarque A, Herrera H, Garcia J. Association of tumor necrosis factor-alpha with early target organ damage in newly diagnosed patients with essential hypertension. J Hypertens 2008; 26:2168-2175.
20. Verlohren S, Dubrovska G, Tsang SY, Essin K, Luft FC, Huang Y, Gollasch M. Visceral periadventitial adipose tissue regulates arterial tone of mesenteric arteries. Hypertension 2004; 44:271-276. (Pubitemid 39167221)
21. Lohn M, Dubrovska G, Lauterbach B, Luft FC, Gollasch M, Sharma AM. Periadventitial fat releases a vascular relaxing factor. FASEB J 2002; 16:1057-1063.
22. Touyz RM, Schiffrin EL. Role of endothelin in human hypertension. Can J Physiol Pharmacol 2003; 81:533-541.
23. Sciarretta S, Ferrucci A, Ciavarella GM, De Paolis P, Venturelli V, Tocci G, et al. Markers of inflammation and fibrosis are related to cardiovascular damage in hypertensive patients with metabolic syndrome. Am J Hypertens 2007; 20:784-791.
24. Newby AC. Met alloproteinase expression in monocytes and macrophages and its relationship to atherosclerotic plaque instability. Arterioscler Thromb Vasc Biol 2008; 28:2108-2114.
25. Emanueli C, Salis MB, Stacca T, Gaspa L, Chao J, Chao L, et al. Rescue of impaired angiogenesis in spontaneously hypertensive rats by intramuscular human tissue kallikrein gene transfer. Hypertension 2001; 38:136-141.
26. Belgore FM, Blann AD, Li-Saw-Hee FL, Beevers DG, Lip GY. Plasma levels of vascular endothelial growth factor and its soluble receptor (SFlt-1) in essential hypertension. Am J Cardiol 2001; 87:805-807; A9.
27. Yu Q, Stamenkovic I. Cell surface-localized matrix met alloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes Dev 2000; 15:163-176.