Dynamic thermodynamic resolution of lithiated N-Boc-N′- alkylpiperazines

Tetrahedron Letters

Volumn 51, Issue 28, 2010, Pages 3642-3644

  Robinson, Steven P ^a   Sheikh, Nadeem S ^a   Baxter, Carl A ^b   Coldham, Iain ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b Merck Sharp & Dohme Limited   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYL GROUP; DIAMINE; LITHIUM; ORGANOLITHIUM COMPOUND; PIPERAZINE DERIVATIVE;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; CHIRALITY; ENANTIOMER; LITHIATION; PROTON TRANSPORT; REACTION ANALYSIS; THERMODYNAMICS;

EID: 77954348993     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2010.05.019     Document Type: Article

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45. + 315.2474; GC analysis (β-cyclodextrin-permethylated, 125 °C) showed the enantiomers eluting at 16.6 min (minor) and 17.5 min (major).