Nonalcoholic fatty liver disease in children

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 13, Issue 4, 2010, Pages 397-402

  Alisi, Anna ^a   Locatelli, Mattia ^b   Nobili, Valerio ^a,b  

^a Unit of Metabolic and Autoimmune Liver Diseases   (United States)

^b Clinica Santa Lucia   (Italy)

Author keywords

children; fibrosis; management; nonalcoholic fatty liver disease; steatohepatitis

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; DOCOSAHEXAENOIC ACID; INSULIN SENSITIZING AGENT; METFORMIN; URSODEOXYCHOLIC ACID;

ABDOMINAL RADIOGRAPHY; ADULTHOOD; CHILD; COMPUTER ASSISTED TOMOGRAPHY; DEATH; DIAGNOSTIC PROCEDURE; DIET; DISEASE SEVERITY; EXERCISE; HUMAN; INSULIN RESISTANCE; LIVER BIOPSY; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER FUNCTION TEST; LIVER INJURY; NONALCOHOLIC FATTY LIVER; NUCLEAR MAGNETIC RESONANCE IMAGING; OXIDATIVE STRESS; PATHOGENESIS; REVIEW; RISK REDUCTION; WEIGHT REDUCTION;

CHILD; FATTY LIVER; HUMANS; INSULIN RESISTANCE; OBESITY; OXIDATIVE STRESS; PREVALENCE; RISK FACTORS;

EID: 77954348367     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0b013e32833aae84     Document Type: Review

References (54)

1. Dunn W, Schwimmer JB. The obesity epidemic and nonalcoholic fatty liver disease in children. Curr Gastroenterol Rep 2008; 10:67-72.
2. Manco M, Marcellini M, Devito R, et al. Metabolic syndrome and liver histology in paediatric nonalcoholic steatohepatitis. Int J Obes (Lond) 2008; 32:381-387.
3. Barshop NJ, Sirlin CB, Schwimmer JB, et al. Review article: epidemiology, pathogenesis and potential treatments of paediatric nonalcoholic fatty liver disease. Aliment Pharmacol Ther 2008; 28:13-24.
4. Patton HM, Sirlin C, Behling C, et al. Pediatric nonalcoholic fatty liver disease: a critical appraisal of current data and implications for future research. J Pediatr Gastroenterol Nutr 2006; 43:413-427.
5. Pardee PE, Lavine JE, Schwimmer JB. Diagnosis and treatment of pediatric nonalcoholic steato hepatitis and the implications for bariatric surgery. Semin Pediatr Surg 2009; 18:144-151.
6. Alisi A, Manco M, Vania A, et al. Pediatric nonalcoholic fatty liver disease in 2009. J Pediatr 2009; 155:469-474.
7. Day CP. NASH-related liver failure: one hit too many? Am J Gastroenterol 2002; 97:1872-1874.
8. PerlemuterG, Bigorgne A, Cassard-Doulcier AM, et al. Nonalcoholic fatty liver disease: from pathogenesis to patient care. Nat Clin Pract Endocrinol Metab 2007; 3:458-469.
9. Moran JR, Gishan FK, Halter SA, et al. Steatohepatitis in obese children: a cause of chronic liver dysfunction. Am J Gastroenterol 1983; 78:374-377.
10. Yeh MM, Brunt EM. Pathology of nonalcoholic fatty liver disease. Am J Clin Pathol 2007; 128:837-847.
11. Kleiner DE, Brunt EM, Van Natta M, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005; 41:1313-1321.
12. Schwimmer JB, Behling C, Newbury R, et al. Histopathology of pediatric nonalcoholic fatty liver disease. Hepatology 2005; 42:641-649.
13. Nobili V, Marcellini M, Devito R, et al. NAFLD in children: a prospective clinical-pathological study and effect of lifestyle advice. Hepatology 2006; 44:458-465.
14. Molleston JP, White F, Teckmann J, Fitzgerald JF. Obese children with steatohepatitis can develop cirrhosis in childhood. Am J Gastrenterol 2002; 97:2460-2462.
15. Schwimmer JB, Deutsch R, Kahen T, et al. Prevalence of fatty liver in children and adolescents. Pediatrics 2006; 118:1388-1393.
16. Suzuki D, Hashimoto E, Kaneda K, et al. Liver failure caused by nonalcoholic steatohepatitis in an obese young male. J Gastroenterol Hepatol 2005; 20:327-329. (Pubitemid 40343294)
17. Feldstein AE, Charatcharoenwitthaya P, Treeprasertsuk S, et al. The natural history of nonalcoholic fatty liver disease in children: a follow-up study for up to 20 years. Gut 2009; 58:1538-1544.
18. Argo CK, Caldwell SH. Epidemiology and natural history of nonalcoholic steatohepatitis. Clin Liver Dis 2009; 13:511-531.
19. Loomba R, Sirlin CB, Schwimmer JB, et al. Advances in pediatric nonalcoholic fatty liver disease. Hepatology 2009; 50:1282-1293.
20. Manco M, Bedogni G, Marcellini M, et al. Waist circumference correlates with liver fibrosis in children with nonalcoholic steatohepatitis. Gut 2008; 57:1283-1287.
21. Sundaram SS, Zeitler P, Nadeau K. The metabolic syndrome and non-alcoholic fatty liver disease in children. Curr Opin Pediatr 2009; 21:529-535.
22. Ciba I, Widhalm K. The association between nonalcoholic fatty liver disease and insulin resistance in 20 obese children and adolescents. Acta Paediatr 2007; 96:109-112.
23. Alisi A, Manco M, Panera N, et al. Association between type two diabetes and nonalcoholic fatty liver disease in youth. Ann Hepatol 2009; 8 (Suppl 1):S44-S50.
24. Deivanayagam S, Mohammed BS, Vitola BE, et al. Nonalcoholic fatty liver disease is associated with hepatic and skeletal muscle insulin resistance in overweight adolescents. Am J Clin Nutr 2008; 88:257-262.
25. Schwimmer JB. Definitive diagnosis and assessment of risk for nonalcoholic fatty liver disease in children and adolescents. Semin Liver Dis 2007; 27:312-318.
26. Ogden CL, Flegal KM, Carroll MD, et al. Prevalence and trends in overweight among US children and adolescents, 1999-2000. JAMA 2002; 288:1728-1732.
27. Williams DE, Cadwell BL, Cheng YJ, et al. Prevalence of impaired fasting glucose and its relationship with cardiovascular disease risk factors in US adolescents, 1999-2000. Pediatrics 2005; 116:1122-1126.
28. Comuzzie AG, Funahashi T, Sonnenberg G, et al. The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome. J Clin Endocrinol Metab 2001; 86:4321-4325.
29. Fabbrini E, Sullivan S, Klein S. Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology 2009; 51:679-689.
30. Tiniakos DG, Vos MB, Brunt EM. Nonalcoholic fatty liver disease: pathology and pathogenesis. Annu Rev Pathol 2010; 5:145-171.
31. Malaguarnera M, Di Rosa M, Nicoletti F, Malaguarnera L. Molecular mechanisms involved in NAFLD progression. J Mol Med 2009; 87:679-695.
32. Marra F, Gastaldelli A, Svegliati Baroni G, et al. Molecular basis and mechan-isms of progression of nonalcoholic steatohepatitis. Trends Mol Med 2008; 14:72-81.
33. Wieckowska A, Feldstein AE. Diagnosis of nonalcoholic fatty liver disease: invasive versus noninvasive. Semin Liver Dis 2008; 28:386-395.
34. Adams LA, Angulo P. Role of liver biopsy and serum markers of liver fibrosis in nonalcoholic fatty liver disease. Clin Liver Dis 2007; 11:25-35; viii.
35. Ali R, Cusi K. New diagnostic and treatment approaches in nonalcoholic fatty liver disease (NAFLD). Ann Med 2009; 41:265-278.
36. Dasarathy S, DasarathyJ, Khiyami A, et al. Validity of real time ultrasound in the diagnosis of hepatic steatosis: a prospective study. J Hepatol 2009; 51:1061-1067.
37. Schwenzer NF, Springer F, Schraml C, et al. Noninvasive assessment and quantification of liver steatosis by ultrasound, computer tomography and magnetic resonance. J Hepatol 2009; 51:433-445.
38. Nobili V, Vizzutti F, Arena U, et al. Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis. Hepatology 2008; 48:442-448.
39. de Ledinghen V, Le Bail B, Rebouissoux L, et al. Liver stiffness measurement in children using FibroScan: feasibility study and comparison with Fibrotest, aspartate transaminase to platelets ratio index, and liver biopsy. J Pediatr Gastroenterol Nutr 2007; 45:443-450.
40. Nobili V, Parkes J, Bottazzo G, et al. Performance of ELF serum markers in predicting fibrosis stage in pediatric nonalcoholic fatty liver disease. Gastro enterology 2009; 136:160-167.
41. Vos MB, BarveS, Joshi-BarveS, et al. Cytokeratin 18, a marker of cell death, is increased in children with suspected nonalcoholic fatty liver disease. J Pediatr Gastroenterol Nutr 2008; 47:481-485.
42. Piemonte F, Petrini S, Gaeta LM, et al. Protein glutathionylation increases in the liver of patients with nonalcoholic fatty liver disease. J Gastroenterol Hepatol 2008; 23 (8 Pt 2):e457-e464.
43. Manco M, Marcellini M, Giannone G, et al. Correlation of serum TNF-alpha levels and histologic liver injury scores in pediatric nonalcoholic fatty liver disease. Am J Clin Pathol 2007; 127:954-960.
44. Lebensztejn DM, Wojtkowska M, Skiba E, et al. Serum concentration of adiponectin, leptin and resistin in obese children with nonalcoholic fatty liver disease. Adv Med Sci 2009; 54:177-182.
45. Alisi A, Manco M, Devito R, et al. Endotoxin and plasminogen activator inhibitor-1 serum levels. J Pediatr Gastroenterol Nutr 2010. [Epub ahead of print]
46. Nobili V, Alkhouri N, Alisi A, et al. Retinol-binding protein 4: a promising circulating marker of liver damage in pediatric nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol 2009; 7:575-579.
47. Socha P, Horvath A, Vajro P, et al. Pharmacological interventions for non-alcoholic fatty liver disease in adults and in children: a systematic review. J Pediatr Gastroenterol Nutr 2009; 48:587-596.
48. Oh MK, Winn J, Poordad F. Review article: diagnosis and treatment of nonalcoholic fatty liver disease. Aliment Pharmacol Ther 2008; 28:503-522.
49. ReinehrT, Schmidt C, Toschke AM, Andler W. Lifestyle intervention in obese children with nonalcoholic fatty liver disease: 2-year follow-up study. Arch Dis Child 2009; 94:437-442.
50. Nobili V, Manco M, Devito R, et al. Lifestyle intervention and antioxidant therapy in children with nonalcoholic fatty liver disease: a randomized, controlled trial. Hepatology 2008; 48:119-128.
51. Nobili V, Manco M, Ciampalini P, et al. Metformin use in children with nonalcoholic fatty liver disease: an open-label, 24-month, observational pilot study. Clin Ther 2008; 30:1168-1176.
52. Lavine JE, Schwimmer JB, Molleston JP, et al. Nonalcoholic Steatohepatitis Clinical Research Network Research Group. Treatment of nonalcoholic fatty liver disease in children: TONIC trial design. Contemp Clin Trials 2010; 31:62-70.
53. Mencin A, Kluwe J, Schwabe RF. Toll-like receptors as targets in chronic liver diseases. Gut 2009; 58:704-720.
54. Nobili V, Alisi A, Vania A, et al. The pediatric NAFLD fibrosis index: a predictor of liver fibrosis in children with nonalcoholic fatty liver disease. BMC Med 2009; 7:21.