Adipose tissue expression of IL-18 and HIV-associated lipodystrophy

AIDS

Volumn 18, Issue 14, 2004, Pages 1956-1958

  Lindegaard, Birgitte ^a,b   Hansen, Ann Brit Eg ^a   Pilegaard, Henriette ^b,c   Keller, Pernille ^a,b   Gerstoft, Jan ^a   Pedersen, Bente Klarlund ^a,b  

^a Rigshosptalet ^*  (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; INTERLEUKIN 18; MESSENGER RNA; NUCLEOSIDE DERIVATIVE; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ADIPOSE TISSUE; APOPTOSIS; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MARKER; DUAL ENERGY X RAY ABSORPTIOMETRY; GLUTEUS MAXIMUS MUSCLE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HIV ASSOCIATED LIPODYSTROPHY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUBCUTANEOUS FAT; TISSUE LEVEL; VIRUS LOAD;

ADIPOSE TISSUE; ANALYSIS OF VARIANCE; CROSS-SECTIONAL STUDIES; HIV-ASSOCIATED LIPODYSTROPHY SYNDROME; HUMANS; INTERLEUKIN-18; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 4744362281     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200409240-00013     Document Type: Article

References (13)

1. Carr A. Toxicity of antiretroviral therapy and implications for drug development. Nat Rev Drug Discov 2003; 2:624-634.
2. Carr A, Samaras K, Burton S, Law M, Freund J, Chisholm DJ, et al. A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors. AIDS 1998; 12:F51-F58.
3. Domingo P, Matias-Guiu X, Pujol RM, Francia E, Lagarda E, Sambeat MA, et al. Subcutaneous adipocyte apoptosis in HIV-1 protease inhibitor-associated lipodystrophy. AIDS 1999; 13: 2261-2267.
4. Bastard JP, Caron M, Vidal H, Jan V, Auclair M, Vigouroux C, et al. Association between altered expression of adipogenic factor SREBP1 in lipoatrophic adipose tissue from HIV-1-infected patients and abnormal adipocyte differentiation and insulin resistance. Lancet 2002; 359:1026-1031.
5. Lihn AS, Richelsen B, Pedersen SB, Haugaard SB, Rathje GS, Madsbad S, et al. Increased expression of TNF-{alpha}, IL-6, and IL-8 in HIV-associated lipodystrophy. Implications for the reduced expression and plasma levels of adiponectin. Am J Physiol Endocrinol Metab 2003; 285:E1072-E1080.
6. Kannisto K, Sutinen J, Korsheninnikova E, Fisher RM, Ehrenborg E, Gertow K, et al. Expression of adipogenic transcription factors, peroxisome proliferator-activated receptor gamma coactivator 1, IL-6 and CD45 in subcutaneous adipose tissue in lipodystrophy associated with highly active antiretroviral therapy. AIDS 2003; 17:1753-1762.
7. Lindegaard B, Hansen A, Gerstoft J, Pedersen B. High plasma level of IL-18 in HIV-infected patients with lipodystrophy. J Acquired Immune Defic Syndr 2004; 36:588-593.
8. Kashiwamura S, Ueda H, Okamura H. Roles of interleukin-18 in tissue destruction and compensatory reactions. J Immunother 2002; 25 (Suppl. 1):S4-S11.
9. Netea MG, Kullberg BJ, Verschueren I, Van Der Meer JW. Interleukin-18 induces production of proinflammatory cytokines in mice: no intermediate role for the cytokines of the tumor necrosis factor family and interleukin-1beta. Eur J Immunol 2000; 30:3057-3060.
10. Dinarello CA. IL-18: a TH1-inducing, proinflammatory cytokine and new member of the IL-1 family. J Allergy Clin Immunol 1999; 103:11-24.
11. Netea MG, Fantuzzi G, Kullberg BJ, Stuyt RJ, Pulido EJ, McIntyre RC Jr, et al. Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemia. J Immunol 2000; 164:2644-2649.
12. Esposito K, Pontillo A, Ciotola M, Di Palo C, Grella E, Nicoletti G, et al. Weight loss reduces interleukin-18 levels in obese women. J Clin Endocrinol Metab 2002; 87:3864-3866.
13. Keller C, Keller P, Marshal S, Pedersen BK. IL-6 gene expression in human adipose tissue in response to exercise - effect of carbohydrate ingestion. J Physiol 2003; 550:927-931.