Inhibition of carbon tetrachloride–mediated apoptosis and oxidative stress by melatonin in experimental liver fibrosis

Toxicology and Industrial Health

Volumn 24, Issue 4, 2008, Pages 201-208

  Ogeturk, M ^a   Kus, I ^a   Pekmez, H ^a   Yekeler, H ^b   Sahin, S ^c   Sarsilmaz, M ^a  

^a FIRAT UNIVERSITY   (Turkey)

^b Elazig Education and Research Hospital ^*  (Turkey)

^c GAZIOSMANPASA UNIVERSITY   (Turkey)

Author keywords

apoptosis; carbon tetrachloride; liver; melatonin; oxidative stress

Indexed keywords

CARBON TETRACHLORIDE; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; MELATONIN; PROTEIN BAX; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DECAPITATION; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; LIVER CELL; LIVER FIBROSIS; LIVER PROTECTION; MALE; NONHUMAN; OXIDATIVE STRESS; RAT;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARBON TETRACHLORIDE; GLUTATHIONE PEROXIDASE; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; MALONDIALDEHYDE; MELATONIN; OXIDATIVE STRESS; RANDOM ALLOCATION; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 57049122890     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1177/0748233708093725     Document Type: Article

References (37)

1. Agency for Toxic Substances and Disease Registry (ATSDR) (2005) Toxicological profile for carbon tetrachloride. US Department of Health and Human Services, Public Health Service, Atlanta, GA, pp. 2–4.
2. Al-Shabanah OA, Alam K, Nagi MN, Al-Rikabi AC, Al-Bekairi AM (2000) Protective effect of aminoguanidine, a nitric oxide synthase inhibitor, against carbon tetrachloride induced hepatotoxicity in mice. Life Sci 66: 265–270.
3. Andrabi SA, Sayeed I, Siemen D, Wolf G, Horn TF (2004) Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for anti-apoptotic effects of melatonin. FASEB J 18: 869–871.
4. Bataller R, Brenner DA (2005) Liver fibrosis. J Clin Invest 115: 209–218.
5. Demirdag K, Bahcecioglu IH, Ozercan IH, Ozden M, Yilmaz S, Kalkan A (2004) Role of L-carnitine in the prevention of acute liver damage induced by carbon tetrachloride in rats. J Gastroenterol Hepatol 19: 333–338.
6. Esterbauer H, Cheeseman KH (1990) Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods Enzymol 186: 407–421.
7. Forsling ML, Stoughton RP, Zhou Y, Kelestimur H, Demaine C (1993) The role of the pineal in the control of the daily patterns of neurohypophysial hormone secretion. J Pineal Res 14: 45–51.
8. Gokalp O, Gulle K, Sulak O, Cicek E, Altuntas I (2003) The effects of methidathion on liver: role of vitamins E and C. Toxicol Ind Health 19: 63–67.
9. Guerrero JM, Reiter RJ (1992) A brief survey of pineal gland-immune system interrelationships. Endocr Res 18: 91–113.
10. Guha M, Maity P, Choubey V, Mitra K, Reiter RJ, Bandyopadhyay U (2007) Melatonin inhibits free radical-mediated mitochondrial-dependent hepatocyte apoptosis and liver damage induced during malarial infection. J Pineal Res 43: 372–381.
11. Ikeda K, Toda M, Tanaka K, Tokumaru S, Kojo S (1998) Increase of lipid hydroperoxides in liver mitochondria and inhibition of cytochrome oxidase by carbon tetrachloride intoxication in rats. Free Radic Res 28: 403–410.
12. Kavakli A, Sahna E, Parlakpinar H, Yahsi S, Ogeturk M, Acet A (2004) The effects of melatonin on focal cerebral ischemia-reperfusion model. Saudi Med J 25: 1751–1752.
13. Kodavanti PR, Joshi UM, Young RA, Meydrech EF, Mehendale HM (1989) Protection of hepatotoxic and lethal effects of CCl4 by partial hepatectomy. Toxicol Pathol 17: 494–505.
14. Kotler M, Rodriguez C, Sainz RM, Antolín I, Menéndez-Peláez A (1998) Melatonin increases gene expression for antioxidant enzymes in rat brain cortex. J Pineal Res 24: 83–89.
15. Kus I, Sarsilmaz M, Ogeturk M, Yilmaz B, Keleştimur H, Oner H (2000) Ultrastructural interrelationship between the pineal gland and the testis in the male rat. Arch Androl 45: 119–124.
16. Kus I, Ogeturk M, Oner H, Sahin S, Yekeler H, Sarsilmaz M (2005) Protective effects of melatonin against carbon tetrachloride-induced hepatotoxicity in rats: a light microscopic and biochemical study. Cell Biochem Funct 23: 169–174.
17. Longoni B, Salgo MG, Pryor WA, Marchiafava PL (1998) Effects of melatonin on lipid peroxidation induced by oxygen radicals. Life Sci 62: 853–859.
18. Maestroni GJM, Covacci V, Conti A (1994) Hematopoietic rescue via T-cell-dependent, endogenous granulocytemacrophage colony-stimulating factor induced by the pineal neurohormone melatonin in tumor-bearing mice. Cancer Res 54: 2429–2432.
19. Mansour MA (2000) Protective effects of thymoquinone and desferrioxamine against hepatotoxicity of carbon tetrachloride in mice. Life Sci 66: 2583–2591.
20. Molpeceres V, Mauriz JL, Garcia-Mediavilla MV, González P, Barrio JP, González-Gallego J (2007) Melatonin is able to reduce the apoptotic liver changes induced by aging via inhibition of the intrinsic pathway of apoptosis. J Gerontol A Biol Sci Med Sci 62: 687–695.
21. Noyan T, Komuroglu U, Bayram I, Sekeroglu MR (2006) Comparison of the effects of melatonin and pentoxifylline on carbon tetrachloride-induced liver toxicity in mice. Cell Biol Toxicol 22: 381–391.
22. Ogeturk M, Kus I, Kavakli A, Oner J, Kukner A, Sarsilmaz M (2005) Reduction of carbon tetrachloride-induced nephropathy by melatonin administration. Cell Biochem Funct 23: 85–92.
23. Ohta Y, Kongo M, Sasaki E, Nishida K, Ishiguro I (1999) Preventive effect of melatonin on the progression of carbon tetrachloride-induced acute liver injury in rats. Adv Exp Med Biol 467: 327–332.
24. Okazaki I, Watanabe T, Niioka M, Sugioka Y, Inagaki Y (2005) Reversibility of liver fibrosis: role of matrix metalloproteinases. In: Razzaque, MS, (ed), Fibrogenesis: cellular and molecular basis, Landes Bioscience, Georgetown, TX, pp. 143–159.
25. Ozdemir D, Uysal N, Tugyan K, Gonenc S, Acikgoz O, Aksu I (2007) The effect of melatonin on endotoxemia-induced intestinal apoptosis and oxidative stress in infant rats. Intensive Care Med 33: 511–516.
26. Paglia DE, Valentine WN (1967) Studies on the quantitative and qualitative characterisation of erythrocyte glutathione peroxidase. J Lab Clin Med 70: 158–169.
27. Recknagel RO, Glende EA, Dolak JA, Waller RL (1989) Mechanisms of carbon tetrachloride toxicity. Pharmacol Ther 43: 139–154.
28. Reiter RJ, Carneiro RC, Oh CS (1997) Melatonin in relation to cellular antioxidative defense mechanisms. Horm Metab Res 29: 363–372.
29. Sigala F, Theocharis S, Sigalas K, Markantonis-Kyroudis S, Papalabros E, Triantafyllou A (2006) Therapeutic value of melatonin in an experimental model of liver injury and regeneration. J Pineal Res 40: 270–279.
30. Sun F, Hamagawa E, Tsutsui C, Ono Y, Ogiri Y, Kojo S (2001) Evaluation of oxidative stress during apoptosis and necrosis caused by carbon tetrachloride in rat liver. Biochim Biophys Acta 1535: 186–191.
31. Sun Y, Oberley LW, Li Y (1988) A simple method for clinical assay of superoxide dismutase. Clin Chem 34: 497–500.
32. Teocharis SE, Margeli AP, Skaltsas SD, Spiliopoulou CA, Koutselinis AS (2001) Induction of metallothionein in the liver of carbon tetrachloride intoxicated rats: an immunohistochemical study. Toxicology 161: 129–138.
33. Wang CY, Ma FL, Liu JT, Tian JW, Fu FH (2007) Protective effect of salvianic acid a on acute liver injury induced by carbon tetrachloride in rats. Biol Pharm Bull 30: 44–47.
34. Wang H, Wei W, Wang NP, Gui SY, Wu L, Sun WY (2005) Melatonin ameliorates carbon tetrachloride-induced hepatic fibrogenesis in rats via inhibition of oxidative stress. Life Sci 77: 1902–1915.
35. Wu Y, Li L, Wen T, Li YQ (2007) Protective effects of echinacoside on carbon tetrachloride-induced hepatotoxicity in rats. Toxicology 232: 50–56.
36. Yoshitake I, Ohishi E, Sano J, Mori T, Kubo K (1991) Effects of KF-14363 on liver fibrosis in rats with chronic liver injury induced by carbon tetrachloride. J Pharmacobiodyn 14: 679–685.
37. Zararsiz I, Kus I, Ogeturk M, Akpolat N, Kose E, Meydan S (2007) Melatonin prevents formaldehyde-induced neurotoxicity in prefrontal cortex of rats: an immunohistochemical and biochemical study. Cell Biochem Funct 25: 413–418.