An autocrine sphingosine-1-phosphate signaling loop enhances NF-κB-activation and survival

BMC Cell Biology

Volumn 11, Issue , 2010, Pages

  Blom, Tomas ^a,c   Bergelin, Nina ^a,b   Meinander, Annika ^a,d   Löf, Christoffer ^a   Slotte, J Peter ^a   Eriksson, John E ^a   Törnquist, Kid ^a,b  

^a ÅBO AKADEMI UNIVERSITY   (Finland)

^b MINERVA FOUNDATION INSTITUTE FOR MEDICAL RESEARCH   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

^d INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; G PROTEIN COUPLED RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BCL XL; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 2; SPHINGOSINE KINASE 1; UNCLASSIFIED DRUG; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (2,6 DICHLORO 4 PYRIDINYL) 1 (1,3 DIMETHYL 4 ISOPROPYL 1H PYRAZOLO[3,4 B]PYRIDIN 6 YL)SEMICARBAZIDE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; DRUG DERIVATIVE; FAS LIGAND; FLAVONOID; LYSOPHOSPHOLIPID; PYRAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SKIP PROTEIN, HUMAN; SMALL INTERFERING RNA; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE;

APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; CARCINOGENESIS; CELL DEATH; CELL FATE; CELL PROTECTION; CELL SECRETION; CELL STIMULATION; CELL SURVIVAL; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE AMPLIFICATION; GENE OVEREXPRESSION; HELA CELL; HUMAN; HUMAN CELL; PROTEIN FUNCTION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; UPREGULATION; WESTERN BLOTTING; BIOSYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; FEEDBACK SYSTEM; GENETICS; METABOLISM; TRANSGENE; TUMOR CELL LINE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AUTOCRINE COMMUNICATION; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES; CELL LINE, TUMOR; CELL SURVIVAL; ENZYME ACTIVATION; FAS LIGAND PROTEIN; FEEDBACK, PHYSIOLOGICAL; FLAVONOIDS; HUMANS; LYSOPHOSPHOLIPIDS; NF-KAPPA B; PYRAZOLES; PYRIDINES; RECEPTORS, LYSOSPHINGOLIPID; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SPHINGOSINE; TRANSGENES;

EID: 77954330306     PISSN: None     EISSN: 14712121     Source Type: Journal    
DOI: 10.1186/1471-2121-11-45     Document Type: Article

References (39)

1. Taha TA, Argraves KM, Obeid LM. Sphingosine phosphate receptors: receptor specificity versus functional redundancy. Biochim Biophys Acta 2004, 1682:48-55.
2. Futerman AH. The complex life of simple sphingolipids. EMBO Rep 2004, 5:777-782. 10.1038/sj.embor.7400208, 1299119, 15289826.
3. Sanchez T, Hla T. Structural and functional characteristics of S1P receptors. J Cell Biochem 2004, 92:913-922. 10.1002/jcb.20127, 15258915.
4. Balthasar S, Samulin J, Ahlgren H, Bergelin N, Lundquist M, Toescu EC, Eggo MC, Törnquist K. Sphingosine 1-phosphate receptor expression profile and regulation of migration in human thyroid cancer cells. Biochem J 2006, 398:547-556. 10.1042/BJ20060299, 1559461, 16753042.
5. Waters CM, Long J, Gorshkova I, Fujiwara Y, Connell M, Belmonte KE, Tigyi G, Natarajan V, Pyne S, Pyne NJ. Cell migration activated by platelet-derived growth factor receptor is blocked by an inverse agonist of the Sphingosine 1-phosphate receptor-1. FASEB J 2006, 20:509-511.
6. Goparaju SK, Jolly PS, Watterson KR, Bektas M, Alvarez S, Sarkar S, Mel L, Ishii I, Chun J, Milstien S, Spiegel S. The S1P2 receptor negatively regulates platelet-derived growth factor-induced motility and proliferation. Mol Cell Biol 2005, 25:4237-4249. 10.1128/MCB.25.10.4237-4249.2005, 1087716, 15870293.
7. Grey A, Chen Q, Callon K, Xu X, Reid IR, Cornish J. The phospholipids sphingosine-1-phosphate and lysophosphatidic acid prevent apoptosis in osteoblastic cells via a signaling pathway involving G(i) proteins and phosphatidylinositol-3kinase. Endocrinology 2002, 143:4755-4763. 10.1210/en.2002-220347, 12446603.
8. Meyer zu Heringdorf D, Liliom K, Schaefer M, Danneberg K, Jaggar JH, Tigyi G, Jakobs KH. Photolysis of intracellular caged sphingosine-1-phosphate causes Ca2+ mobilization independently of G-protein-coupled receptors. FEBS Lett 2003, 554:443-449. 10.1016/S0014-5793(03)01219-5, 14623109.
9. Ghosh TK, Bian J. Sphingosine 1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium. J Biol Chem 1994, 269:22628-22635.
10. Hait NC, Allegood J, Maceyka M, Strub GM, Harikumar KB, Singh SK, Luo C, Marmorstein R, Kordula T, Milstien S, Spiegel S. Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science 2009, 325:1254-1257. 10.1126/science.1176709, 2850596, 19729656.
11. Liao J-J, Huang M-C, Graler M, Huang Y, Qiu H, Goetzl EJ. Distinctive T cell-suppressive signals from nuclearized type 1 sphingosine 1-phosphate G-protein coupled receptors. J Biol Chem 2007, 282:1964-1972. 10.1074/jbc.M608597200, 17121832.
12. Goetzl EJ, Wang W, McGiffert C, Liao JJ, Huang MC. Sphingosine 1-phosphate as an intracellular messenger and extracellular mediator in immunity. Acta Pediatr Suppl 2007, 96:49-52.
13. Kleuser B, Maceyka M, Spiegel S. Stimulation of nuclear sphingosine kinase activity by platelet-derived growth factor. FEBS Lett 2001, 503:85-90. 10.1016/S0014-5793(01)02697-7, 11513860.
14. Edsall LC, Pirianov GG, Spiegel S. Involvement of sphingosine 1-phosphate in nerve growth factor-mediated neuronal survival and differentiation. J Neurosci 1997, 17:6952-6960.
15. Osawa Y, Banno Y, Nagaki M, Brenner DA, Naiki T, Nozawa Y, Nakashima S, Moriwaki H. TNF-alpha-induced sphingosine 1-phosphate-induced activation of phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. J Immunol 2001, 167:173-180.
16. Billich A, Bornancin F, Mechtcheriakova D, Natt F, Huesken D, Baumruker T. Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators. Cell Signal 2005, 17:1203-1217. 10.1016/j.cellsig.2004.12.005, 16038795.
17. Meyer zu Heringdorf D, Lass H, Kuchar I, Lipinski M, Alemany R, Rumenapp U, Jakobs KH. Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors. Eur J Pharmacol 2001, 414:145-154. 10.1016/S0014-2999(01)00789-0, 11239914.
18. Blom T, Slotte JP, Pitson SM, Törnquist K. Enhancement of intracellular sphingosine-1-phosphate production by inositol 1,4,5-trisphosphate-evoked calcium mobilization in HEK-293 cells: endogenous sphingosine-1-phosphate as a modulator of the calcium response. Cell Signal 2005, 17:827-836. 10.1016/j.cellsig.2004.11.022, 15763425.
19. Pitson SM, Moretti PA, Zebol JR, Lynn HE, Xia P, Vadas MA, Wattenberg BW. Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation. EMBO J 2003, 22:5491-5500. 10.1093/emboj/cdg540, 213794, 14532121.
20. Sutherland CM, Moretti PA, Hewitt NM, Bagley CJ, Vadas MA, Pitson SM. The calmodulin-binding site of sphingosine kinase and its role in agonist-dependent translocation of sphingosine kinase 1 to the plasma membrane. J Biol Chem 2006, 281:11693-11701. 10.1074/jbc.M601042200, 16522638.
21. Young KW, Willets JM, Parkinson MJ, Bartlett P, Spiegel S, Nahorski SR, Chaliss RA. Ca2+/calmodulin-dependent translocation of sphingosine kinase: role in plasma membrane relocation but not activation. Cell Calcium 2003, 33:119-128. 10.1016/S0143-4160(02)00205-1, 12531188.
22. Stahelin RV, Hwang JH, Kim J-H, Park Z-Y, Johnson KR, Obeid LM, Cho W. The mechanism of membrane targeting of human sphingosine kinase 1. J Biol Chem 2005, 280:43030-43038. 10.1074/jbc.M507574200, 16243846.
23. Delon C, Manifava M, Wood E, Thompson D, Krugmann S, Ktistakis NT. Sphingosine kinase 1 is an intracellular effector of phosphatidic acid. J Biol Chem 2004, 279:44763-44764. 10.1074/jbc.M405771200, 15310762.
24. Anelli V, Bassi R, Tettamanti G, Viani P, Riboni L. Extracellular release of newly synthesized sphingosine-1-phosphate by cerebellar granule cells and astrocytes. J Neurochem 2005, 92:1204-1215. 10.1111/j.1471-4159.2004.02955.x, 15715670.
25. Weigert A, Johann AM, von Knethen A, Schmidt H, Geisslinger G, Brune B. Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate. Blood 2006, 108:1635-1642. 10.1182/blood-2006-04-014852, 16690965.
26. Kim RH, Takabe K, Milstien S, Spiegel S. Export and functions of sphingosine-1-phosphate. Biochim Biophys Acta 2009, 1791:692-696. 2763566, 19268560.
27. Ancellin N, Colmont C, Su J, Li Q, Mitterreder N, Chae SS, Stefansson S, Liau G, Hla T. Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation. J Biol Chem 2002, 277:6667-6675. 10.1074/jbc.M102841200, 11741921.
28. Venkataraman K, Thangada S, Michaud J, Oo ML, Ai Y, Lee YM, Wu M, Parikh NS, Khan F, Proia RL, Hla T. Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient. Biochem J 2006, 397:461-471. 10.1042/BJ20060251, 1533315, 16623665.
29. Johnson KR, Becker KP, Faccinetti MM, Hannun YA, Obeid LM. PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). J Biol Chem 2002, 277:35257-35262. 10.1074/jbc.M203033200, 12124383.
30. Pitson SM, Moretti PA, Zebol JR, Xia P, Gamble JR, Vadas MA, D'Andrea RJ, Wattenberg BW. Expression of a catalytic inactive sphingosine kinase mutant blocks agonist-induced sphingosine kinase activation. A dominant-negative sphingosine kinase. J Biol Chem 2000, 275:33945-33950. 10.1074/jbc.M006176200, 10944534.
31. Shatrov VA, Lehmann V, Chouaib S. Sphingosine-1-phosphate mobilizes intracellular calcium and activates transcription factor NF-kappa B in U937 cells. Biochem Biophys Res Commun 1997, 234:121-124. 10.1006/bbrc.1997.6598, 9168973.
32. Siehler S, Wang Y, Fan X, Windh RT, Manning DR. Sphingosine 1-phosphate activates nuclear factor-kappa B through Edg receptors. Activation through Edg-3 and Edg-5, but not Edg-1, in human embryonic kidney 293 cells. J Biol Chem 2001, 276:48733-48739. 10.1074/jbc.M011072200, 11673450.
33. Ki SH, Choi MJ, Lee CH, Kim SG. Gα12 specifically regulates COX-2 induction by sphingosine 1-phosphate. J Biol Chem 2007, 282:1938-1947. 10.1074/jbc.M606080200, 17098744.
34. Wang F, Van Brocklyn JR, Hobson JP, Movafagh S, Zukowska-Grojec Z, Milstien S, Spiegel S. Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis. J Bio Chem 1999, 274:35343-35350.
35. Katsuma S, Hada Y, Ueda T, Shiojima S, Hirasawa A, Tanoue A, Takagaki K, Ohgi T, Yano J, Tsujimoto G. Signalling mechanisms in sphingosine 1-phosphate-promoted mesangial cell proliferation. Genes Cells 2002, 7:1217-1230. 10.1046/j.1365-2443.2002.00594.x, 12485162.
36. Jolly PS, Bektas M, Watterson KW, Sankala H, Payne SG, Milstien S, Spiegel S. Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors. Blood 2005, 105:4736-4742. 10.1182/blood-2004-12-4686, 1894993, 15741218.
37. Hsieh HL, Wu CB, Sun CC, Liao CH, Lau YT, Yang CM. Sphingosine-1-phosphate induces COX-2 expression via PI3K/Akt and p42/p44 MAPK pathways in rat vascular smooth muscle cells. J Cell Physiol 2006, 207:757-766. 10.1002/jcp.20621, 16508949.
38. Hanafusa N, Yatomi Y, Yamada K, Hori Y, Nangaku M, Okuda T, Fujita T, Fukagawa M. Sphingosine 1-phosphate stimulates rat mesangial cell proliferation from outside the cells. Nephrol Dial Transplant 2002, 17:580-586. 10.1093/ndt/17.4.580, 11917049.
39. Chae SS, Paik JH, Furneaux H, Hla T. Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference. J Clin Invest 2004, 114:1082-1089. 522258, 15489955.