In rat renal fibroblasts, mycophenolic acid inhibits proliferation and production of the chemokine CCL2, stimulated by tumour necrosis factor-

British Journal of Pharmacology

Volumn 160, Issue 7, 2010, Pages 1611-1620

  Chang, Hong Wei ^a   Wu, Vin Cent ^a   Wu, Kwan Dun ^a   Huang, Hong Yu ^a   Hsieh, Bor Shen ^a   Chen, Yung Ming ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

apoptosis; mitogen activated protein kinase; monocyte chemoattractant protein 1; mycophenolic acid

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; BROXURIDINE; CASPASE 3; CYCLIN D2; CYCLIN E; DNA; INOSINATE DEHYDROGENASE INHIBITOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; MYCOPHENOLIC ACID; PROTEIN P21; PROTEIN P27; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA FRAGMENTATION; DOWN REGULATION; DRUG ACTIVITY; DRUG INHIBITION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; FLOW CYTOMETRY; IMMUNOBLOTTING; KIDNEY CELL; KIDNEY DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; STEADY STATE; TUMOR SUPPRESSOR GENE; UPREGULATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CELL CULTURE TECHNIQUES; CELL LINE; CELL PROLIFERATION; CHEMOKINE CCL2; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBROBLASTS; FLOW CYTOMETRY; KIDNEY; MYCOPHENOLIC ACID; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77954324864     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00837.x     Document Type: Article

References (28)

1. Alexander SPH, Mathie A, Peters JA (2009). Guide to Receptors and Channels (GRAC), 4th edn. Br J Pharmacol 158 (Suppl. 1 S1 S254.
2. Badid C, Vincent M, McGregor B, Melin M, Hadj-Aissa A, Veysseyre C et al. (2000). Mycophenolate mofetil reduces myofibroblast infiltration and collagen III deposition in rat remnant kidney. Kidney Int 58:51 61.
3. Boldt A, Barten MJ, Sagner A, Mohr FW, Adams V, Dhein S et al. (2006). The influence of immunosuppressive drugs on T- and B-cell apoptosis via p53-mediated pathway in vitro and in vivo. Transplantation 82:422 427.
4. Chiara M, Menegatti E, Di Simone D, Davit A, Bellis D, Sferch D et al. (2005). Mycophenolate mofetil and roscovitine decrease cyclin expression and increase p27(kip1) expression in anti Thy1 mesangial proliferative nephritis. Clin Exp Immunol 139:225 235.
5. Cox LS (1997). Multiple pathways control cell growth and transformation: overlapping and independent activities of p53 and p21Cip1/WAF1/Sdi1. J Pathol 183:134 140.
6. Farivar AS, MacKinnon-Patterson B, Barnes AD, Mulligan MS (2005). The effect of anti-inflammatory properties of mycophenolate mofetil on the development of lung reperfusion injury. J Heart Lung Transplant 24:2235 2242.
7. Gagliardini E, Benigni A (2007). Therapeutic potential of TGF-beta inhibition in chronic renal failure. Expert Opin Biol Ther 7:293 304.
8. Gartel AL, Tyner AL (2002). The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Mol Cancer Ther 1:639 649.
9. Guo H, Leung JC, Chan LY, Lui SL, Tsang AW, Lai KN (2005). Modulation of intra-pulmonary TGF-beta expression by mycophenolate mofetil in lupus prone MRL/lpr mice. Lupus 14:583 592.
10. Ha H, Kim MS, Park J, Huh JY, Huh KH, Ahn HJ et al. (2006). Mycophenolic acid inhibits mesangial cell activation through p38 MAPK inhibition. Life Sci 79:1561 1567.
11. Kim JY, Huh KH, Park YJ, Fang Y, Kang CM, Kim YS (2008). Molecular mechanisms of cell death of mycophenolic acid-treated primary isolated rat islets: implication of mitogen-activated protein kinase activation. Transplant Proc 40:2575 2577.
12. Laliberté J, Yee A, Xiong Y, Mitchell BS (1998). Effects of guanine nucleotide depletion on cell cycle progression in human T lymphocytes. Blood 91:2896 2904.
13. Lin SL, Chen YM, Chien CT, Chiang WC, Tsai CC, Tsai TJ (2002). Pentoxifylline attenuated the renal disease progression in rats with remnant kidney. J Am Soc Nephrol 13:3024 3026.
14. Ma LJ, Fogo AB (2007). Modulation of glomerulosclerosis. Semin Immunopathol 29:385 395.
15. Morath C, Schwenger V, Beimler J, Mehrabi A, Schmidt J, Zeier M et al. (2006). Antifibrotic actions of mycophenolic acid. Clin Transplant 20 (Suppl. 17 25 29.
16. Okada H, Kalluri R (2005). Cellular and molecular pathways that lead to progression and regression of renal fibrogenesis. Curr Mol Med 5:467 474.
17. Qi W, Chen X, Poronnik P, Pollock CA (2006). The renal cortical fibroblast in renal tubulointerstitial fibrosis. Int J Biochem Cell Biol 38:1 5.
18. Qian Y, Feldman E, Pennathur S, Kretzler M, Brosius FC 3rd. (2008). From fibrosis to sclerosis: mechanisms of glomerulosclerosis in diabetic nephropathy. Diabetes 57:1439 1445.
19. Romero F, Rodríguez-Iturbe B, Parra G, González L, Herrera-Acosta J, Tapia E (1999). Mycophenolate mofetil prevents the progressive renal failure induced by 5/6 renal ablation in rats. Kidney Int 55:945 955.
20. Sepe V, Libetta C, Giuliano MG, Adamo G, Dal Canton A (2008). Mycophenolate mofetil in primary glomerulopathies. Kidney Int 73:154 162.
21. Sherr CJ, Roberts JM (1999). CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 13:1501 1512.
22. Takebe N, Cheng X, Fandy TE, Srivastava RK, Wu S, Shankar S et al. (2006). IMP dehydrogenase inhibitor mycophenolate mofetil induces caspase-dependent apoptosis and cell cycle inhibition in multiple myeloma cells. Mol Cancer Ther 5:457 466.
23. Toyoshima H, Hunter T (1994). p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell 78:64 74.
24. Utimura R, Fujihara CK, Mattar AL, Malheiros DM, Noronha IL, Zatz R (2003). Mycophenolate mofetil prevents the development of glomerular injury in experimental diabetes. Kidney Int 63:209 216. (Pubitemid 35463923)
25. Végso G, Sebestyén A, Paku S, Barna G, Hajdu M, Tóth M et al. (2007). Antiproliferative and apoptotic effects of mycophenolic acid in human B-cell non-Hodgkin lymphomas. Leuk Res 31:1003 1008.
26. Wu YG, Lin H, Qi XM, Wu GZ, Qian H, Zhao M et al. (2006). Prevention of early renal injury by mycophenolate mofetil and its mechanism in experimental diabetes. Int Immunopharmacol 6:445 453.
27. Yamaguchi T, Hashiguchi K, Katsuki S, Iwamoto W, Tsuruhara S, Terada S (2008). Activation of the intrinsic and extrinsic pathways in high pressure-induced apoptosis of murine erythroleukemia cells. Cell Mol Biol Lett 13:49 57.
28. Zoja C, Abbate M, Remuzzi G (2006). Progression of chronic kidney disease: insights from animal models. Curr Opin Nephrol Hypertens 15:250 257.