-
1
-
-
0036562364
-
From the analyst's couch, Trends in development cycles
-
Bolten BM and Degregorio T, From the analyst's couch, Trends in development cycles, Nat Rev Drug Discov1: pp335-336, 2002
-
(2002)
Nat Rev Drug Discov
, vol.1
, pp. 335-336
-
-
Bolten, B.M.1
Degregorio, T.2
-
2
-
-
0037374498
-
The price of innovation: New estimates of drug development costs
-
Dimasi JA, Hansen RW and Grabowski HG, The price of innovation: new estimates of drug development costs, J Health Econ 22: pp151-185, 2003
-
(2003)
J Health Econ
, vol.22
, pp. 151-185
-
-
Dimasi, J.A.1
Hansen, R.W.2
Grabowski, H.G.3
-
3
-
-
14644438916
-
-
Truhlar DG, Howe WJ, Hopfinger AJ, Blaney J and Dammkoehler RE, Rational Drug Design, 1999
-
(1999)
Rational Drug Design
-
-
Truhlar, D.G.1
Howe, W.J.2
Hopfinger, A.J.3
Blaney, J.4
Dammkoehler, R.E.5
-
5
-
-
4043062916
-
De novo drug design: Integration of structure-based and ligand-based methods
-
Dean PM, Lloyd DG and Todorov NP, De novo drug design: integration of structure-based and ligand-based methods, Curr Opin Drug Discov Devel 7: pp347-353, 2004
-
(2004)
Curr Opin Drug Discov Devel
, vol.7
, pp. 347-353
-
-
Dean, P.M.1
Lloyd, D.G.2
Todorov, N.P.3
-
6
-
-
0037082199
-
The emerging importance of predictive ADME simulation in drug discovery
-
Selick HE, Beresford AP and Tarbit MH, The emerging importance of predictive ADME simulation in drug discovery, Drug Discov Today 7: pp109-116, 2002
-
(2002)
Drug Discov Today
, vol.7
, pp. 109-116
-
-
Selick, H.E.1
Beresford, A.P.2
Tarbit, M.H.3
-
9
-
-
0031552362
-
Development and validation of a genetic algorithm for flexible docking
-
Jones G, Willett P, Glen RC, Leach AR and Taylor R, Development and validation of a genetic algorithm for flexible docking, J Mol Biol 267: pp727-748, 1997
-
(1997)
J Mol Biol
, vol.267
, pp. 727-748
-
-
Jones, G.1
Willett, P.2
Glen, R.C.3
Leach, A.R.4
Taylor, R.5
-
10
-
-
0003955925
-
Fundamentals and Applications in Chemistry and Biology
-
Hansch C and Leo A, Exploring QSAR Volume 1: Fundamentals and Applications in Chemistry and Biology, 1995
-
(1995)
Exploring QSAR
, vol.1
-
-
Hansch, C.1
Leo, A.2
-
11
-
-
0037364162
-
ADMET in silico modelling: Towards prediction paradise?
-
Van de Waterbeemd H and Gifford E, ADMET in silico modelling: towards prediction paradise? Nat Rev Drug Discov 2: pp192-204, 2003
-
(2003)
Nat Rev Drug Discov
, vol.2
, pp. 192-204
-
-
Van De Waterbeemd, H.1
Gifford, E.2
-
12
-
-
0031024171
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinski CA, Lombardo F, Dominy BW and Feeney PJ, Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings, Adv Drug Deliv Rev 23: pp3-25, 1997
-
(1997)
Adv Drug Deliv Rev
, vol.23
, pp. 3-25
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
-
13
-
-
0036136527
-
Computational models for cytochrome P450: A predictive electronic model for aromatic oxidation and hydrogen atom abstraction
-
Jones JP, Mysinger M and Korzewka KR, Computational models for cytochrome P450: a predictive electronic model for aromatic oxidation and hydrogen atom abstraction, Drug Metab Dispos 30: pp7-12, 2002
-
(2002)
Drug Metab Dispos
, vol.30
, pp. 7-12
-
-
Jones, J.P.1
Mysinger, M.2
Korzewka, K.R.3
-
14
-
-
21744446063
-
Predictive models for hERG potassium channel blockers
-
Cianchetta G, Li Y, Kang J, Rampe D, Fravolini A, Cruciani G and Vaz RJ: Predictive models for hERG potassium channel blockers, Bioorg Med Chem Lett 15: pp3,637-3,642, 2005
-
(2005)
Bioorg Med Chem Lett
, vol.15
-
-
Cianchetta, G.1
Li, Y.2
Kang, J.3
Rampe, D.4
Fravolini, A.5
Cruciani, G.6
Vaz, R.J.7
-
16
-
-
33846020720
-
Focus on Success: Using a Probabilistic Approach to Achieve an Optimal Balance of Compound Properties in Drug Discovery
-
Segall MD, Beresford AP, Gola JMR, Hawksley D and Tarbit MH, Focus on Success: Using a Probabilistic Approach to Achieve an Optimal Balance of Compound Properties in Drug Discovery, Expert Opin Drug Metab Toxicology, 2: pp325-337, 2006
-
(2006)
Expert Opin Drug Metab Toxicology
, vol.2
, pp. 325-337
-
-
Segall, M.D.1
Beresford, A.P.2
Gola, J.M.R.3
Hawksley, D.4
Tarbit, M.H.5
|