A noveland practical synthesis of substituted 2-ethoxy benzimidazole: Candesartan cilexetil

Tetrahedron

Volumn 66, Issue 29, 2010, Pages 5402-5406

  Wang, Ping ^a   Zheng, Guo Jun ^b   Wang, Ya Ping ^b   Wang, Xiang Jing ^a   Li, Yan ^a   Xiang, Wen Sheng ^a  

^a NORTHEAST AGRICULTURAL UNIVERSITY   (China)

^b Zhejiang Hisun Pharmaceutical Co Ltd Company   (China)

Author keywords

Antihypertensive; Candesartan cilexetil; Receptor antagonist; Synthesis

Indexed keywords

2 ETHOXY BENZIMIDAZOLE; BENZIMIDAZOLE DERIVATIVE; BENZOIC ACID; CANDESARTAN HEXETIL; METHYL 2 AMINO 3 NITROBENZOATE; METHYL 2 BROMO 3 (DIETHOXY METHYLENEAMINO) BENZOATE; METHYLAMINE; NITROBENZOIC ACID DERIVATIVE; UNCLASSIFIED DRUG; [2' (1 TRIYL 1H TETRAZOL 5 YL) BIPHENYL 4 YL]METHANAMINE;

ARTICLE; ARYLATION; DRUG STRUCTURE; DRUG SYNTHESIS; PRIORITY JOURNAL; RING CLOSING METATHESIS;

EID: 77954312650     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2010.05.037     Document Type: Article

References (26)

1. Elliott, M.E.; Catt, K.J.; Goodfriend, T.L.N.Engl.J.Med.1996, 334, 1649-1654.
2. Shibouta, Y.; Inada, Y.; Ojima, M.; Wada, T.; Noda, M.; Sanada, T.; Kubo, K.; Kohara, Y.; Naka, T.; Nishikawa, K.J.Pharmacol.Exp.Ther.1993, 266, 114-120.
3. Ferreiros, N.; Dresen, S.; Alonso, R.M.; Weinmann, W.J.Chromatogr., B 2007, 855, 134-138.
4. Nishikawa, K.; Naka, T.; Chatani, F.; Yoshimura, Y.J.Hum.Hypertens 1997, 11, S9-S18.
5. van Lier, J.J.; van Heiningen, P.N.M.; Sunzel, M.J.Hum.Hypertens 1997, 11, S27-S28.
6. Elmfeldt, D.; George, M.; Hubner, R.; Olofsson, B.J.Hum.Hypertens 1997, 11, S49-S53
7. Buhlmayer, P.; Furet, P.; Criscione, L.; De Gasparo, M.; Whitebread, S.; Schmi-dlin, T.; Lattmann, R.; Wood, J.Bioorg.Med.Chem.Lett.1994, 4, 29-34
8. Bernhart, C.A.; Perreaut, P.M.; Ferrari, B.P.; Muneaux, Y.A.; Assens, J.L.A.; Muneaux, C.F.; Taillades, J.E.J.Med.Chem.1993, 36, 3371-3380.
9. Carini, D.J.; Duncia, J.V.; Aldrich, P.E.; Chiu, A.T.; Johnson, A.L.; Pierce, M.E.; Price, W.A.; M, E.; Santella, J.B., III; Wells, G.J.; Wexler, R.R.; Wong, P.C.; Yoo, S.E.; Timmermans, P.B.M.W.M.J.Med.Chem.1991, 34, 2525-2547.
10. Vauquelin, G.; Fierens, F.; van Liefde, I.J.Hypertens.2006, 24, S23-S30.
11. Garcia-Donaire, J.A.; Ruilope, L.M.Diabetes Res.Clin.Pract.2007, 76S, S22-S30.
12. Naka, T.; Nishikawa, K.; Kato, T.EP, 459136, 1991.
13. Etinger, M.Y.; Boris, F.WO, 2005037821, 2005.
14. Diaz Martinez, A.; Rafecas Jane, L.; Riera Escale, A.; Pasto Aguila, M.; Ecija Queralt, M.WO, 2006067215, 2006
15. Kubo, K.; Kohara, Y.; Yoshimura, Y.; Inada, Y.; Shibouta, Y.; Furukawa, Y.; Kato, T.; Nishikawa, K.; Nakd, T.J.Med.Chem.1993, 36, 2182-2195.
16. Kobe, T.N.; Kyoto, K.N.; Higashiosaka, T.K.U.S.Patent 5,196,444, 1993
17. Kubo, K.; Kohara, Y.; Yoshimura, Y.; Inada, Y.; Shibouta, Y.; Furukawa, Y.; Kato, T.; Nishikawa, K.; Nakd, T.J.Med.Chem.1993, 36, 2343-2349.
18. Wang, Y.P.; Li, Y.G.; Li, Y.L.; Zheng, G.J.; Li, Y.; Koecher, S.U.S.Patent 2,008,114,045, 2008.
19. Wang, Y.P.; Li, Y.G.; Li, Y.L.; Zheng, G.J.; Li, Y.; Koecher, S.WO, 06063578, 2006.
20. March, J.Advanced Organic Chemistry, 4th ed.; Wiley: New York, NY,1992; p 723.
21. Krolski, M.E.; Renaldo, A.F.; Rudisill, D.E.; Stille, J.K.J.Org.Chem.1988, 53, 117 0-117 6.
22. Tieckelmann, H.; Post, H.W.J.Org.Chem.1948, 13, 268-274.
23. Murru, S.; Patel, B.K.; Bras, J.L.; Muzart, J.J.Org.Chem.2009, 74, 2217-2220.
24. Zou, B.L.; Yuan, Q.L.; Ma, D.W.Angew.Chem., Int.Ed.2007, 46, 2598-2601.
25. Maheswaran, H.; Krishna, G.G.; Prasanth, K.L.; Srinivas, V.; Chaitanya, G.K.; Bhanuprakash, K.Tetrahedron 2008, 64, 2471-2479.
26. Rohde, J.J.; Szczepankiewicz, B.G.; Kurukulasuriya, R.Org.Lett.2005, 7,1833-18 3 5.