Synthesis of ortho-functionalized 4-aminomethylpyridazines as substrate-like semicarbazide-sensitive amine oxidase inhibitors

Chemical and Pharmaceutical Bulletin

Volumn 58, Issue 7, 2010, Pages 964-970

  Haider, Norbert ^a   Hochholdinger, Iris ^a   Mátyus, Péter ^b   Wobus, Andrea ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

4 Aminomethylpyridazine; Diaza benzylamine; Selective debenzylation; Semicarbazide sensitive amine oxidase inhibitor; Semicarbazide sensitive amine oxidase vascular adhesion protein 1

Indexed keywords

4 (AMINOMETHYL) N,N' DIETHYLPYRIDAZINE 3,5 DIAMINE; AMINE OXIDASE (COPPER CONTAINING); BENZYL DERIVATIVE; DIAMINE; ENZYME INHIBITOR; LEWIS ACID; NITRILE; NITROGEN; PYRIDAZINE DERIVATIVE; PYRIDAZINONE DERIVATIVE; SEMICARBAZIDE; UNCLASSIFIED DRUG; 4-(AMINOMETHYL)-N,N'-DIETHYLPYRIDAZINE-3,5-DIAMINE; RECOMBINANT PROTEIN;

ARTICLE; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HYDROGENATION; NUCLEAR OVERHAUSER EFFECT; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; GENETICS; METABOLISM; SYNTHESIS;

AMINE OXIDASE (COPPER-CONTAINING); DIAMINES; ENZYME INHIBITORS; HUMANS; PYRIDAZINES; RECOMBINANT PROTEINS;

EID: 77954301471     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.58.964     Document Type: Article

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