Increasing parvovirus filter throughput of monoclonal antibodies using ion exchange membrane adsorptive pre-filtration

Biotechnology and Bioengineering

Volumn 106, Issue 4, 2010, Pages 627-637

  Brown, Arick ^a   Bechtel, Charity ^a   Bill, Jerome ^a   Liu, Hui ^a   Liu, Jun ^a   McDonald, Dan ^a   Pai, Satyan ^a   Radhamohan, Asha ^a   Renslow, Ryan ^a   Thayer, Brooke ^a   Yohe, Stefan ^a   Dowd, Chris ^a  

^a GENENTECH INC   (United States)

Author keywords

Filter fouling; Ion exchange membrane; Monoclonal antibody; Nanofiltration; Parvovirus; Pre filtration; Virus filtration

Indexed keywords

ADSORBERS; COST EFFECTIVE; FILTER FOULING; FOULANTS; HIGH MOLECULAR WEIGHT; HYDRODYNAMIC RADIUS; MEMBRANE CHROMATOGRAPHY; MONOCLONAL ANTIBODIES (MABS); PARVOVIRUS; PRE-FILTRATION; SEDIMENTATION VELOCITIES; TRACE LEVEL;

ADSORPTION; ALLERGIES; ION EXCHANGE; IONS; MERGERS AND ACQUISITIONS; MICROFILTRATION; MONOCLONAL ANTIBODIES; NANOFILTRATION; SURFACE PLASMON RESONANCE; THROUGHPUT; VIRUSES;

ION EXCHANGE MEMBRANES;

ADSORBENT; MONOCLONAL ANTIBODY;

ADSORPTION; ARTICLE; CONDUCTANCE; COST EFFECTIVENESS ANALYSIS; ELUTION; HYDRODYNAMICS; ION EXCHANGE; MEMBRANE FILTER; MOLECULAR WEIGHT; NONHUMAN; PARVOVIRUS; PH; POROSITY; SEDIMENTATION RATE;

ANTIBODIES, MONOCLONAL; CULTURE MEDIA; ELECTRIC CONDUCTIVITY; FILTRATION; HYDROGEN-ION CONCENTRATION; ION EXCHANGE; MEMBRANES; PARVOVIRUS;

PARVOVIRUS;

EID: 77954298804     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22729     Document Type: Article

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