The effects of L-thyroxin replacement therapy on bone minerals and body composition in hypothyroid children

Archives of Medical Science

Volumn 6, Issue 3, 2010, Pages 407-413

  Salama, Hassan M ^a   El Dayem, Soha A ^a   Yousef, Hala ^a   Fawzy, Ashraf ^a   Abou Ismail, Laila ^a   El Lebedy, Dalia Hassan ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Bone density; Bone mineral; Children; Dual energy x ray absorptiometry; Hypothyroid; Levothyroxine 4

Indexed keywords

CALCIUM; COLLAGEN; DEOXYPYRIDINOLINE; LEVOTHYROXINE; OSTEOCALCIN; OSTEOPROTEGERIN; PHOSPHORUS;

ABDOMINAL FAT; ARTICLE; BODY COMPOSITION; BODY FAT; BONE DENSITY; BONE MINERAL; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR NECK; HORMONE SUBSTITUTION; HUMAN; HYPOTHYROIDISM; LUMBAR SPINE; MALE; OSSIFICATION; OSTEOCLAST ACTIVITY; PROTEIN DEGRADATION; SCHOOL CHILD; SCORING SYSTEM; THERAPY EFFECT; URINALYSIS;

EID: 77954260648     PISSN: 17341922     EISSN: None     Source Type: Journal    
DOI: 10.5114/aoms.2010.14264     Document Type: Article

References (34)

1. Devdhar M, Ousman YH, Burman KD. Hypothyroidism. Endocrinol Metabol Clin 2007; 36: 595-615.
2. Numbenjapon N, Costin G, Gilsanz V, Pitukcheewanont P. Low cortical bone density measured by computed tomography in children and adolescents with untreated hyperthyroidism. J Pediatr 2007; 150: 527-30. (Pubitemid 46628813)
3. Wexler JA, Sharretts J. Thyroid and bone. Endocrinol Metabol Clin 2007; 36: 673-705.
4. Kosinska A, Syrenicz A, Kosinski B, Garanty-Bogacka B, Syrenicz M, Gromniak E. Osteoporosis in thyroid diseases. Endokrynol Pol 2005; 56: 185-93.
5. Wiersinga WM. Thyroid hormone replacement therapy. Horm Res 2001; 56 Suppl 1: 74-81. (Pubitemid 34062899)
6. Mikosch P. Effects of thyroid disorders on the bone. Wien Med Wochenschr 2005; 155: 444-53.
7. Briot K. Non-corticosteroid drug-induced metabolic bone disease. Presse Med 2006; 35: 1579-83.
8. Britto JM, Fenton AJ, Holloway WR, Nicholson GC. Osteoblasts mediate thyroid hormone stimulation of osteoclastic bone resorption. Endocrinology 1994; 134: 169-76.
9. Rubin K, Schirduan V, Gendreau P, Sarfarazi M, Mendola R, Dalsky G. Predictors of axial and peripheral bone mineral density in healthy children and adolescents, with special attention to the role of puberty. J Pediatr 1993; 123: 863-70.
10. Pitukcheewanont P, Safani D, Gilsanz V, Klein M, Chongpison Y, Costin G. Quantitative computed tomography measurements of bone mineral density in prepubertal children with congenital hypothyroidism treated with L-thyroxine. J Pediatr Endocrinol Metab 2004; 17: 889-93.
11. Demartini Ade A, Kulak CA, Borba VC, et al. Bone mineral density of children and adolescents with congenital hypothyroidism. Arq Bras Endocrinol Metabol 2007; 51: 1084-92.
12. Ribot C, Tremollieres F, Pouilles JM, Louvet JP. Bone mineral density and thyroid hormone therapy. Clin Endocrinol (Oxf) 1990; 33: 143-53.
13. Tumer L, Hasanoglu A, Cinaz P, Bideci A. Bone mineral density and metabolism in children treated with L-thyroxine. J Pediatr Endocrinol Metab 1999; 12: 519-23.
14. Salerno M, Lettiero T, Esposito-del Puente A, et al. Effect of long-term L-thyroxine treatment on bone mineral density in young adults with congenital hypothyroidism. Eur J Endocrinol 2004; 151: 689-94.
15. Power MJ, Fottrell PF. Osteocalcin: diagnostic methods and clinical applications. Crit Rev Clin Lab Sci 1991; 28: 287-335.
16. Lipton A, Ali SM, Leitzel K, et al. Serum osteoprotegerin levels in healthy controls and cancer patients. Clin Cancer Res 2002; 8: 2306-10.
17. Eastell R, Colwell A, Hampton L, Reeve J. Biochemical markers of bone resorption compared with estimates of bone resorption from radiotracer kinetic studies in osteoporosis. J Bone Miner Res 1997; 12: 59-65.
18. Leger J, Ruiz JC, Guibourdenche J, Kindermans C, Garabedian M, Czernichow P. Bone mineral density and metabolism in children with congenital hypothyroidism after prolonged L-thyroxine therapy. Acta Paediatr 1997; 86: 704-10.
19. Kooh SW, Brnjac L, Ehrlich RM, Qureshi R, Krishnan S. Bone mass in children with congenital hypothyroidism treated with thyroxine since birth. J Pediatr Endocrinol Metab 1996; 9: 59-62.
20. Saggese G, Bertelloni S, Baroncelli GI, Costa S, Ceccarelli C. Bone mineral density in adolescent females treated with L-thyroxine: a longitudinal study. Eur J Pediatr 1996; 155: 452-7. (Pubitemid 26170116)
21. Sampath TK, Simic P, Sendak R, et al. Thyroid-stimulating hormone restores bone volume, microarchitecture, and strength in aged ovariectomized rats. J Bone Miner Res 2007; 22: 849-59. (Pubitemid 351339745)
22. Williams JB. Adverse effects of thyroid hormones. Drugs Aging 1997; 11: 460-9.
23. Toft AD. Thyroxine therapy. N Engl J Med 1994; 331: 174-80.
24. Lee SH, Desai SS, Shetty G, et al. Bone mineral density of proximal femur and spine in Korean children between 2 and 18 years of age. J Bone Miner Metab 2007; 25: 423-30. (Pubitemid 350043695)
25. Brunova J, Kasalicky P, Lanska V. The assessment of body composition using DEXA in patients with thyroid dysfunction. Cas Lek Cesk 2007; 146: 497-502.
26. Lomenick JP, El-Sayyid M, Smith WJ. Effect of levothyroxine treatment on weight and body mass index in children with acquired hypothyroidism. J Pediatr 2008; 152: 96-100. (Pubitemid 350265927)
27. Lim S, Joung H, Shin CS, et al. Body composition changes with age have gender-specific impacts on bone mineral density. Bone 2004; 35: 792-8. (Pubitemid 39141882)
28. Leonard MB, Shults J, Wilson BA, Tershakovec AM, Zemel BS. Obesity during childhood and adolescence augments bone mass and bone dimensions. Am J Clin Nutr 2004; 80: 514-23.
29. Kerr DA, Papalia S, Morton A, Dick I, Dhaliwal S, Prince RL. Bone mass in young women is dependent on lean body mass. J Clin Densitom 2007; 10: 319-26.
30. Qin MW, Yu W, Xu L, et al. Bone mineral and body composition analysis of whole body in 292 normal subjects assessed by dual X-ray absorptio-metry. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2003; 25: 66-9.
31. Jurimae T, Hurbo T, Jurimae J. Relationships between legs bone mineral density, anthropometry and jumping height in prepubertal children. Coll Antropol 2008; 32: 61-6.
32. Ebina K, Fukuhara A, Shimomura I. The role of adipo cytokine in bone metabolism. Clin Calcium 2008; 18: 623-30.
33. Leunissen RW, Stijnen T, Boot AM, Hokken-Koelega AC. Influence of birth size and body composition on bone mineral density in early adulthood. The PROGRAM-study. Clin Endocrinol (Oxf) 2009; 70: 245-51.
34. Matsuo T, Douchi T, Nakae M, Uto H, Oki T, Nagata Y. Relationship of upper body fat distribution to higher regional lean mass and bone mineral density. J Bone Miner Metab 2003; 21: 179-83.