Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption

Alcohol and Alcoholism

Volumn 45, Issue 4, 2010, Pages 303-311

  Kovanen, Leena ^a   Saarikoski, Sirkku T ^a   Haukka, Jari ^a   Pirkola, Sami ^a,b   Aromaa, Arpo ^a   Lönnqvist, Jouko ^a,c   Partonen, Timo ^a  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL ABUSE; ALCOHOL CONSUMPTION; ALCOHOLISM; ALLELE; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; POPULATION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; ADULT; DRINKING BEHAVIOR; GENE FREQUENCY; GENETICS; MIDDLE AGED; PSYCHOLOGIC TEST;

ADCYAP1 PROTEIN, HUMAN; ARNTL PROTEIN, HUMAN; ARNTL2 PROTEIN, HUMAN; CLOCK PROTEIN, HUMAN; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; TRANSCRIPTION FACTOR ARNTL; TRANSCRIPTION FACTOR CLOCK; VASOACTIVE INTESTINAL POLYPEPTIDE;

ADULT; ALCOHOL DRINKING; ALCOHOLISM; ARNTL TRANSCRIPTION FACTORS; CIRCADIAN RHYTHM; CLOCK PROTEINS; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; INTERVIEW, PSYCHOLOGICAL; MALE; MIDDLE AGED; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; POLYMORPHISM, SINGLE NUCLEOTIDE; VASOACTIVE INTESTINAL PEPTIDE;

EID: 77954250323     PISSN: 07350414     EISSN: 14643502     Source Type: Journal    
DOI: 10.1093/alcalc/agq035     Document Type: Article

References (78)

1. Acimovic J, Fink M, Pompon D et al. (2008) CREM modulates the circadian expression of CYP51, HMGCR and cholesterogenesis in the liver. Biochem Biophys Res Commun 376:206-10.
2. Asher G, Schibler U. (2006) A CLOCK-less clock. Trends Cell Biol 16:547-9.
3. Aston-Jones G, Smith RJ, Moorman DE et al. (2008) Role of lateral hypothalamic orexin neurons in reward processing and addiction. Neuropharmacology 56:112-21.
4. Badia-Elder NE, Gilpin NW, Stewart RB. (2007) Neuropeptide Y modulation of ethanol intake: effects of ethanol drinking history and genetic background. Peptides 28:339-44.
5. Barrett JC, Fry B, Maller J et al. (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263-5.
6. Blum K, Noble EP, Sheridan PJ et al. (1991) Association of the A1 allele of the D2 dopamine receptor gene with severe alcoholism. Alcohol 8:409-16.
7. Blum K, Noble EP, Sheridan PJ et al. (1990) Allelic association of human dopamine D2 receptor gene in alcoholism. JAMA 263:2055-60.
8. Brainard GC, MorganWW. (1987) Light-induced stimulation of retinal dopamine: a dose-response relationship. Brain Res 424:199-203.
9. Chen CP, Kuhn P, Advis JP et al. (2004) Chronic ethanol consumption impairs the circadian rhythm of pro-opiomelanocortin and period genes mRNA expression in the hypothalamus of the male rat. J Neurochem 88:1547-54.
10. Cheng HY, Dziema H, Papp J et al. (2006) The molecular gatekeeper Dexras1 sculpts the photic responsiveness of the mammalian circadian clock. J Neurosci 26:12984-95.
11. Cheng HY, Obrietan K, Cain SW et al. (2004) Dexras1 potentiates photic and suppresses nonphotic responses of the circadian clock. Neuron 43:715-28.
12. Cleck JN, Blendy JA. (2008) Making a bad thing worse: adverse effects of stress on drug addiction. J Clin Invest 118:454-61.
13. Colwell CS, Michel S, Itri J et al. (2004) Selective deficits in the circadian light response in mice lacking PACAP. Am J Physiol Regul Integr Comp Physiol 287:R1194-201.
14. Comasco E, Nordquist N, Göktürk C et al. (2010) The clock gene PER2 and sleep problems: association with alcohol consumption among Swedish adolescents. Ups J Med Sci 115:41-8.
15. Dardente H, Fortier EE, Martineau V et al. (2007) Cryptochromes impair phosphorylation of transcriptional activators in the clock: a general mechanism for circadian repression. Biochem J 402:525-36.
16. Dawson DA. (2000) Alcohol consumption, alcohol dependence, and all-cause mortality. Alcohol Clin Exp Res 24:72-81.
17. Dawson DA, Goldstein RB, Grant BF. (2007) Rates and correlates of relapse among individuals in remission from DSM-IV alcohol dependence: a 3-year follow-up. Alcohol Clin Exp Res 31:2036-45.
18. Duan J, Wainwright MS, Comeron JM et al. (2003) Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. Hum Mol Genet 12:205-16.
19. Epstein EE, Labouvie E, McCrady BS et al. (2004) Development and validity of drinking pattern classification: binge, episodic, sporadic, and steady drinkers in treatment for alcohol problems. Addict Behav 29:1745-61.
20. Farnell YZ, Allen GC, Neuendorff N et al. (2009) Effects of neonatal alcohol exposure on vasoactive intestinal polypeptide neurons in the rat suprachiasmatic nucleus. Alcohol 43:387-96.
21. Gonzalez MM, Aston-Jones G. (2008) Light deprivation damages monoamine neurons and produces a depressive behavioral phenotype in rats. Proc Natl Acad Sci USA 105:4898-903.
22. Hallikainen T, Hietala J, Kauhanen J et al. (2003) Ethanol consumption and DRD2 gene TaqI a polymorphism among socially drinking males. Am J Med Genet A 119:152-5.
23. Hampp G, Ripperger JA, Houben T et al. (2008) Regulation of monoamine oxidase A by circadian-clock components implies clock influence on mood. Curr Biol 18:678-83.
24. Hannibal J. (2006) Roles of PACAP-containing retinal ganglion cells in circadian timing. Int Rev Cytol 251:1-39.
25. Heath AC, Madden PA, Bucholz KK et al. (1999) Genetic differences in alcohol sensitivity and the inheritance of alcoholism risk. Psychol Med 29:1069-81.
26. Hietala J, West C, Syvalahti E et al. (1994) Striatal D2 dopamine receptor binding characteristics in vivo in patients with alcohol dependence. Psychopharmacology (Berl) 116:285-90.
27. Hill SY, Hoffman EK, Zezza N et al. (2008) Dopaminergic mutations: within-family association and linkage in multiplex alcohol dependence families. Am J Med Genet B Neuropsychiatr Genet 147B:517-26.
28. Hughes AT, Piggins HD. (2008) Behavioral responses of Vipr2-/-mice to light. J Biol Rhythms 23:211-9.
29. Ikeda M, Nomura M. (1997) cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS protein (BMAL1) and identification of alternatively spliced variants with alternative translation initiation site usage. Biochem Biophys Res Commun 233:258-64.
30. Ikeda M, Yu W, Hirai M et al. (2000) cDNA cloning of a novel bHLH-PAS transcription factor superfamily gene, BMAL2: its mRNA expression, subcellular distribution, and chromosomal localization. Biochem Biophys Res Commun 275:493-502.
31. Ilveskoski E, Kajander OA, Lehtimaki T et al. (2001) Association of neuropeptide y polymorphism with the occurrence of type 1 and type 2 alcoholism. Alcohol Clin Exp Res 25:1420-2.
32. Johansson C, Willeit M, Smedh C et al. (2003) Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference. Neuropsychopharmacology 28:734-9.
33. Kauhanen J, Karvonen MK, Pesonen U et al. (2000) Neuropeptide Y polymorphism and alcohol consumption in middle-aged men. Am J Med Genet 93:117-21.
34. Ko CH, Takahashi JS. (2006) Molecular components of the mammalian circadian clock. Hum Mol Genet 15:R271-7.
35. Lamont EW, Robinson B, Stewart J et al. (2005) The central and basolateral nuclei of the amygdala exhibit opposite diurnal rhythms of expression of the clock protein Period2. Proc Natl Acad Sci USA 102:4180-4.
36. Lappalainen J, Kranzler HR, Malison R et al. (2002) A functional neuropeptide Y Leu7Pro polymorphism associated with alcohol dependence in a large population sample from the United States. Arch Gen Psychiatry 59:825-31.
37. Lu Y, Dollé ME, Imholz S et al. (2008) Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. J Lipid Res 49:2582-9.
38. Lynch WJ, Girgenti MJ, Breslin FJ et al. (2008) Gene profiling the response to repeated cocaine self-administration in dorsal striatum: a focus on circadian genes. Brain Res 1213:166-77.
39. Malison RT, Kranzler HR, Yang BZ et al. (2006) Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoia. Psychiatr Genet 16:245-9.
40. Mansour HA, Wood J, Logue T et al. (2006) Association study of eight circadian genes with bipolar I disorder, schizoaffective disorder and schizophrenia. Genes Brain Behav 5:150-7.
41. McClung CA, Sidiropoulou K, Vitaterna M et al. (2005) Regulation of dopaminergic transmission and cocaine reward by the Clock gene. Proc Natl Acad Sci USA 102:9377-81.
42. Mottagui-Tabar S, Prince JA, Wahlestedt C et al. (2005) A novel single nucleotide polymorphism of the neuropeptide Y (NPY) gene associated with alcohol dependence. Alcohol Clin Exp Res 29:702-7.
43. Munafo MR, Johnstone EC, Welsh KI et al. (2005) Association between the DRD2 gene Taq1A (C32806T) polymorphism and alcohol consumption in social drinkers. Pharmacogenomics J 5:96-101.
44. Munafo MR, Matheson IJ, Flint J. (2007) Association of the DRD2 gene Taq1A polymorphism and alcoholism: a meta-analysis of case-control studies and evidence of publication bias. Mol Psychiatry 12:454-61.
45. Nestler EJ. (2005) Is there a common molecular pathway for addiction? Nat Neurosci 8:1445-9.
46. Nievergelt CM, Kripke DF, Barrett TB et al. (2006) Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 141B:234-41.
47. Park D, Lee S, Jun K et al. (2003) Translation of clock rhythmicity into neural firing in suprachiasmatic nucleus requires mGluRPLCbeta4 signaling. Nat Neurosci 6:337-8.
48. Partonen T, Treutlein J, Alpman A et al. (2007) Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression. Ann Med 39:229-38.
49. Perreau-Lenz S, Spanagel R. (2008) The effects of drugs of abuse on clock genes. Drug News Perspect 21:211-7.
50. Piggins HD, Cutler DJ. (2003) The roles of vasoactive intestinal polypeptide in the mammalian circadian clock. J Endocrinol 177:7-15.
51. Ponce G, Perez-Gonzalez R, Aragues M et al. (2009) The ANKK1 kinase gene and psychiatric disorders. Neurotox Res 16:50-9.
52. Purcell S, Cherny SS, Sham PC. (2003) Genetic power calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 19:149-50.
53. Purcell S, Neale B, Todd-Brown K et al. (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81:559-75.
54. Retey JV, Adam M, Honegger E et al. (2005) A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans. Proc Natl Acad Sci USA 102:15676-81.
55. Sakurai T. (2007) The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness. Nat Rev Neurosci 8:171-81.
56. Sangoram AM, Saez L, Antoch MP et al. (1998) Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription. Neuron 21:1101-13.
57. Sasaki M, Yoshitane H, Du NH et al. (2009) Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription. J Biol Chem 284:25149-59.
58. Shaper AG. (1990) Alcohol and mortality: a review of prospective studies. Br J Addict 85:837-47discussion 849-61.
59. Sher L. (2004) Alcoholism and seasonal affective disorder. Compr Psychiatry 45:51-6.
60. Sipila T, Kananen L, Greco D et al. (2010) An association analysis of circadian genes in anxiety disorders. Biol Psychiatry 67:1163-70.
61. Smith L, Watson M, Gates S et al. (2008) Meta-analysis of the association of the Taq1A polymorphism with the risk of alcohol dependency: a HuGE gene-disease association review. Am J Epidemiol 167:125-38.
62. Smith NL, Bis JC, Biagiotti S et al. (2008) Variation in 24 hemostatic genes and associations with non-fatal myocardial infarction and ischemic stroke. J Thromb Haemost 6:45-53.
63. Smith NL, Hindorff LA, Heckbert SR et al. (2007) Association of genetic variations with nonfatal venous thrombosis in postmenopausal women. JAMA 297:489-98.
64. Spanagel R, Pendyala G, Abarca C et al. (2005) The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption. Nat Med 11:35-42.
65. Spanagel R, Rosenwasser AM, Schumann G et al. (2005) Alcohol consumption and the body's biological clock. Alcohol Clin Exp Res 29:1550-7.
66. Storey JD. (2003) The positive false discovery rate: a Bayesian interpretation and the q-value. Ann Stat 31:2013-35.
67. Szabo G, Macsai M, Schek E et al. (1998) The effect of vasoactive intestinal polypeptide and pituitary adenylate cyclase activating polypeptide on tolerance to morphine and alcohol in mice. Ann N Y Acad Sci 865:566-9.
68. Tafti M, Petit B, Chollet D et al. (2003) Deficiency in short-chain fatty acid beta-oxidation affects theta oscillations during sleep. Nat Genet 34:320-5.
69. Thanos PK, Volkow ND, Freimuth P et al. (2001) Overexpression of dopamine D2 receptors reduces alcohol self-administration. J Neurochem 78:1094-103.
70. Ukai H, Kobayashi TJ, Nagano M et al. (2007) Melanopsin-dependent photo-perturbation reveals desynchronization underlying the singularity of mammalian circadian clocks. Nat Cell Biol 9:1327-34.
71. Vitaterna MH, King DP, Chang AM et al. (1994) Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science 264:719-25.
72. Volkow ND, Wang GJ, Maynard L et al. (2002) Effects of alcohol detoxification on dopamine D2 receptors in alcoholics: a preliminary study. Psychiatry Res 116:163-72.
73. Wittchen HU, Lachner G, Wunderlich U et al. (1998) Test-retest reliability of the computerized DSM-IV version of the Munich-Composite International Diagnostic Interview (M-CIDI). Soc Psychiatry Psychiatr Epidemiol 33:568-78.
74. Yujnovsky I, Hirayama J, Doi M et al. (2006) Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1. Proc Natl Acad Sci U S A 103:6386-91.
75. Zhou YD, Barnard M, Tian H et al. (1997) Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system. Proc Natl Acad Sci USA 94:713-8.
76. Zhu G, Pollak L, Mottagui-Tabar S et al. (2003) NPY Leu7Pro and alcohol dependence in Finnish and Swedish populations. Alcohol Clin Exp Res 27:19-24.
77. Zill P, Preuss UW, Koller G et al. (2008) Analysis of single nucleotide polymorphisms and haplotypes in the neuropeptide Y gene: no evidence for association with alcoholism in a German population sample. Alcohol Clin Exp Res 32:430-4.
78. Zimmermann P, Wittchen HU, Hofler M et al. (2003) Primary anxiety disorders and the development of subsequent alcohol use disorders: a 4-year community study of adolescents and young adults. Psychol Med 33:1211-22.