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Volumn 1, Issue 13, 2010, Pages 1973-1976

Diffusion-influenced transport of ions across a transmembrane channel with an internal binding site

Author keywords

[No Author keywords available]

Indexed keywords

BINDING RATE CONSTANTS; DIFFUSION-INFLUENCED REACTIONS; EXPERIMENTAL DATA; INFLUENZA A; ION FLUXES; ION TRANSPORTS; MICROSCOPIC THEORY; PROTON CHANNELS; STRUCTURE AND DYNAMICS; TRANSMEMBRANES;

EID: 77954247559     PISSN: None     EISSN: 19487185     Source Type: Journal    
DOI: 10.1021/jz100683t     Document Type: Article
Times cited : (22)

References (24)
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    • The M2 protein functions as a tetramer; hence the His37 tetrad provides four protonation sites. The channel becomes activated when viral exterior pH is lowed to ∼6. At this pH, two protons are always bound to the His37 tetrad (ref 7); it is the binding of the third proton that leads to channel conductance. Hence what we model here is the binding/unbinding of a proton to/from a doubly protonated His37 tetrad. That the doubly protonated His37 tetrad has two equivalent protonation sites serves to double the binding and unbinding rate constants. Here we model the two protonation sites together as an absorbing disk.
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    • i -, occurs on the millisecond time scale.
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.