Concomitant boost dose escalation plus large-field preoperative chemoradiation in locally advanced carcinoma of the uterine cervix: Results of a phase i study (LARA-CC-1)

Gynecologic Oncology

Volumn 118, Issue 2, 2010, Pages 128-133

  MacChia, Gabriella ^a   Ferrandina, Gabriella ^a   Deodato, Francesco ^a   Ruggieri, Valeria ^b   Massaccesi, Mariangela ^a   Salutari, Vanda ^a   Valentini, Vincenzo ^b   Cellini, Numa ^b   Scambia, Giovanni ^b   Morganti, Alessio G ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

Author keywords

Cervix; Concomitant boost; Dose escalation; Extended field

Indexed keywords

CISPLATIN; FLUOROURACIL;

ADULT; ADVANCED CANCER; ARTICLE; BONE METASTASIS; CANCER CHEMOTHERAPY; CANCER LOCALIZATION; CANCER RELAPSE; CANCER STAGING; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; COHORT ANALYSIS; CONTINUOUS INFUSION; DIARRHEA; DISEASE FREE SURVIVAL; ENTEROCOLITIS; FEMALE; FIBROSIS; FOLLOW UP; HUMAN; LEG EDEMA; LYMPHATIC DRAINAGE; MAXIMUM TOLERATED DOSE; NAUSEA; OVERALL SURVIVAL; PELVIS LYMPHADENECTOMY; PHASE 1 CLINICAL TRIAL; PLANNING; PREOPERATIVE CARE; PREOPERATIVE RADIOTHERAPY; PRIORITY JOURNAL; PROCTITIS; PROSPECTIVE STUDY; RADIATION DOSE; RADICAL HYSTERECTOMY; SALVAGE THERAPY; STANDARD; STUDY DESIGN; TREATMENT RESPONSE; TUMOR VOLUME; URINE RETENTION; UTERINE CERVIX CARCINOMA; VERTEBRA; VOMITING;

ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CISPLATIN; COMBINED MODALITY THERAPY; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; FLUOROURACIL; HUMANS; HYSTERECTOMY; LYMPH NODE EXCISION; MIDDLE AGED; NEOPLASM STAGING; PREOPERATIVE CARE; RADIOTHERAPY DOSAGE; TREATMENT OUTCOME; UTERINE CERVICAL NEOPLASMS;

EID: 77954244586     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2010.04.017     Document Type: Article

References (42)

1. National Cancer Institute Clinical Announcement. Concurrent Chemoradiation for Cervical Cancer. February, 1999. (http://www.cancer.gov/ newscenter/cervicalcancer) (Last Access 11/03/08).
2. B.J. Monk, and K.S.T. Tewari Invasive cervical cancer P.J. DiSaia, W.T. Creasman, Clinical gynecologic oncology. 7th 2007 Elsevier Philadelphia PA 55 124
3. A. Jemal, T. Murray, and E. Ward Cancer statistics CA Cancer J Clin 55 2005 10 30
4. G. Ferrandina, F. Legge, and A. Fagotti Preoperative concomitant chemoradiotherapy in locally advanced cervical cancer: safety, outcome, and prognostic measures Gynecol Oncol 107 2007 S127 S132
5. D. Mariagrazia, F. Anna, and F. Gabriella Preoperative chemoradiotherapy in locally advanced cervical cancer: long-term outcome and complications Gynecol Oncol 99 2005 S166 S170
6. M.L. Berman, H. Keys, and W. Creasman Survival and patterns of recurrence in cervical cancer metastatic to periaortic lymph nodes (a Gynecologic Oncology Group study) Gynecol Oncol 19 1984 8 16
7. M. Rotman, M. John, and J. Boyce Prognostic factors in cervical carcinoma: implications in staging and management Cancer 48 1981 560 567
8. T. Toita, M. Nakano, and M. Higashi Prognostic value of cervical size and pelvic lymph node status assessed by computed tomography for patients with uterine cervical cancer treated by radical radiation therapy Int J Radiat Oncol Biol Phys 33 1995 843 849
9. P.W. Grigsby, C.A. Perez, and K.S. Chao Radiation therapy for carcinoma of the cervix with biopsy-proven positive para-aortic lymph nodes Int J Radiat Oncol Biol Phys 49 2001 733 738
10. B.M. Beadle, A. Jhingran, and S.S. Yom Patterns of regional recurrence after definitive radiotherapy for cervical cancer Int J Radiat Oncol Biol Phys 76 2010 1396 1403
11. M. Rotman, T.F. Pajak, and K. Choi Prophylactic extended-field irradiation of para-aortic lymph nodes in stages IIB and bulky IB and IIA cervical carcinomas. Ten-year treatment results of RTOG 79-20 JAMA 274 1995 387 393
12. C. Haie, M.H. Pejovic, and A. Gerbaulet Is prophylactic para-aortic irradiation worthwhile in the treatment of advanced cervical carcinoma? Results of a controlled clinical trial of the EORTC radiotherapy group Radiother Oncol 11 1988 101 112
13. S. Beriwal, G.N. Gan, and D.E. Heron Early clinical outcome with concurrent chemotherapy and extended-field, intensity-modulated radiotherapy for cervical cancer Int J Radiat Oncol Biol Phys 68 2007 166 171
14. P.J. Eifel, K. Winter, and M. Morris Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer: an update of radiation therapy oncology group trial (RTOG) 90-01 J Clin Oncol 22 2004 872 880 (Pubitemid 41103599)
15. B. Lengelé, and P. Scalliet Anatomical bases for the radiological delineation of lymph node areas. Part III: pelvis and lower limbs Radiother Oncol 92 2009 22 33
16. C.A. Perez, and S. Breaux Radiation therapy alone in the treatment of carcinoma of uterine cervix. I. Analysis of tumor recurrence Cancer 51 8 1983 1393 1402
17. J.M. Classe, P. Rauch, and J.F. Rodier Surgery after concurrent chemoradiotherapy and brachytherapy for the treatment of advanced cervical cancer: morbidity and outcome: results of a multicenter study of the GCCLCC (Group des Chirurgiens de Centre de Lutte contre le Cancer) Gynecol Oncol 102 2006 523 529
18. A. Gasinska, J.F. Fowler, B.K. Lind, and K. Urbanski Influence of overall treatment time and radiobiological parameters on biologically effective doses in cervical cancer patients treated with radiation therapy alone Acta Oncol 43 2004 657 666
19. M. Chun, S. Kang, and H. Ryu Modified partial hyperfractionation in radiotherapy for bulky uterine cervical cancer: reduction of overall treatment time Int J Radiat Oncol Biol Phys 47 2000 973 977
20. N. Cellini, D. Smaniotto, and G. Scambia Chemoradiation with concomitant boost followed by radical surgery in locally advanced cervical cancer: a dose-escalation study Am J Clin Oncol 31 2008 280 284
21. G. Arbuck Workshop on phase I study design. Ninth NCI/EORTC new drug development symposium, Amsterdam, March 12, 1996 Ann Oncol 7 1996 567 573
22. S. Piantadosi Clinical trials: a methodologic perspective 1997 John Wiley New York 151/S 155/S
23. R. Glynne-Jones, D. Sebag-Montefiore, and T.S. Maughan A phase I dose escalation study of continuous oral capecitabine in combination with oxaliplatin and pelvic radiation (XELOX-RT) in patients with locally advanced rectal cancer Ann Oncol 17 1 2006 Jan 50 56
24. A.G. Morganti, M. Balducci, and M. Salvati A phase I dose-escalation study (ISIDE-BT-1) of accelerated IMRT in combination with temozolomide in patients with glioblastoma Int J Radiat Oncol Biol Phys 77 2010 92 97
25. G. Macchia, S. Cilla, G. Ferrandina, G. Padula, F. Deodato, and C. Digesù Postoperative intensity-modulated radiotherapy in low-risk endometrial cancers: final results of a phase I study Int J Radiat Oncol Biol Phys 76 2010 1390 1395
26. H.R. Withers, H.D. Thames, and L.J. Peters A new isoeffect curve for change in dose per fraction Radiat Oncol 1 1983 187 191
27. C. Capirci, C. Polico, and G. Mandoliti Dislocation of small bowel volume within box pelvic treatment fields, using new "up down table" device Int J Radiat Oncol Biol Phys 51 2001 465 473
28. M.S. Piver, F. Rutledge, and J.P. Smith Five classes of extended hysterectomy for women with cervical cancer Obstet Gynecol 44 1974 265 272
29. J.D. Cox, J. Stetz, and T.F. Pajak Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC) Int J Radiat Oncol Biol Phys 31 1995 1341 1346
30. D. Chassagne, P. Sismondi, and J.C. Horiot A glossary for reporting complications of treatment in gynecological cancers Radiother Oncol 26 1993 195 202
31. P. Therasse, S.G. Arbuck, and E.A. Eisenhauer New guidelines to evaluate the response to treatment in solid tumors J Natl Cancer Inst 92 2000 205 216 (Pubitemid 30099779)
32. F.L. Kaplan, and P. Meier Nonparametric estimation from incomplete observations Am J Stat Assoc 53 1958 457 481
33. M.A. Varia, B.N. Bundy, and G. Deppe Cervical carcinoma metastatic to para-aortic nodes: extended field radiation therapy with concomitant 5-fluorouracil and cisplatin chemotherapy: a Gynecologic Oncology Group study Int J Radiat Oncol Biol Phys 42 1998 1015 1023
34. J.L. Walker, A. Morrison, P. DiSilvestro, V.E. von Gruenigen Gynecologic Oncology Group A phase I/II study of extended field radiation therapy with concomitant paclitaxel and cisplatin chemotherapy in patients with cervical carcinoma metastatic to the para-aortic lymph nodes: a Gynecologic Oncology Group study Gynecol Oncol 112 2009 78 84
35. B.M. Sood, G.R. Gorla, and M. Garg Extended-field radiotherapy and high-dose-rate brachytherapy in carcinoma of the uterine cervix: clinical experience with and without concomitant chemotherapy Cancer 97 2003 1781 1788
36. M. Morris, P.J. Eifel, and J. Lu Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high risk cervical cancer N Eng J Med 340 1999 1137 1143
37. P.G. Rose, B.N. Bundy, and E.B. Watkins Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer N Eng J Med 340 1999 1144 1153
38. J.H. Malfetano, H. Keys, and M.J. Cunningham Extended field radiation and cisplatin for stage IIB and IIIB cervical carcinoma Gynecol Oncol 67 1997 203 207
39. R. Lanciano, A. Calkins, and B. Bundy A randomized comparison of radiation plus weekly cisplatin versus protracted venous infusion 5-FU in combination with concurrent radiation in advanced cervix cancer: a GOG study J Clin Oncol 23 2005 8289 8295
40. B.J. Monk, C. Tian, P.G. Rose, and R. Lanciano Which clinical/pathologic factors matter in the era of chemoradiation as treatment for locally advanced cervical carcinoma? Analysis of two Gynecologic Oncology Group (GOG) trials Gynecol Oncol 105 2007 427 433
41. B.D. Kavanagh, H.L. Gieschen, and R.K. Schmidt-Ullrich A pilot study of concomitant boost accelerated superfractionated radiotherapy for stage III cancer of the uterine cervix Int J Radiat Oncol Biol Phys 38 1997 561 568
42. G. Houvenaeghel, L. Lelievre, and M. Buttarelli Contribution of surgery in patients with bulky residual disease after chemoradiation for advanced cervical carcinoma Eur J Surg Oncol 33 2007 498 503