A Phase I Dose-Escalation Study (ISIDE-BT-1) of Accelerated IMRT With Temozolomide in Patients With Glioblastoma

International Journal of Radiation Oncology Biology Physics

Volumn 77, Issue 1, 2010, Pages 92-97

  Morganti, Alessio G ^a   Balducci, Mario ^b   Salvati, Maurizio ^c   Esposito, Vincenzo ^c   Romanelli, Pantaleo ^c   Ferro, Marica ^a   Calista, Franco ^a   Digesù, Cinzia ^a   Macchia, Gabriella ^a   Ianiri, Massimo ^d   Deodato, Francesco ^a   Cilla, Savino ^a   Piermattei, Angelo ^a   Valentini, Vincenzo ^b   Cellini, Numa ^b   Cantore, Gian Paolo ^c  

^a CATHOLIC UNIVERSITY   (Italy)

^b FONDAZIONE POLICLINICO UNIVERSITARIO A GEMELLI IRCCS   (Italy)

^c IRCCS NEUROMED   (Italy)

^d Cardarelli Hospital   (Italy)

Author keywords

Glioblastoma; IMRT; Phase I; Radiotherapy; Temozolomide

Indexed keywords

ADVERSE EFFECT; CLINICAL TARGET VOLUMES; CLINICAL TRIAL; DISEASE PROGRESSION; DOSE ESCALATION; DOSE LIMITING TOXICITY; DOSE-ESCALATION STUDY; GLIOBLASTOMAS; IMRT; INTENSITY-MODULATED RADIOTHERAPY; INVERSE APPROACH; MAXIMUM TOLERATED DOSE; PHASE I; PLANNING TARGET VOLUMES; RADIATION THERAPY ONCOLOGY GROUPS; SKIN TOXICITY; STEP-AND-SHOOT; TARGET VOLUMES; TEMOZOLOMIDE; TUMOR BED; UP TIME;

PHYSICAL THERAPY; RADIATION EFFECTS; RADIOTHERAPY; TARGETS;

TOXICITY;

FOTEMUSTINE; TEMOZOLOMIDE;

ADULT; AGED; ARTICLE; BRAIN BIOPSY; CANCER GROWTH; CANCER RADIOTHERAPY; CANCER SURGERY; CLINICAL ARTICLE; CLINICAL TRIAL; CONJUNCTIVITIS; EDEMA; EYE TOXICITY; FEMALE; FOLLOW UP; GLIOBLASTOMA; HEADACHE; HUMAN; INTENSITY MODULATED RADIATION THERAPY; MALE; MAXIMUM TOLERATED DOSE; NAUSEA; NEUROTOXICITY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RADIATION DOSE FRACTIONATION; SKIN TOXICITY; THROMBOCYTOPENIA; TUMOR BIOPSY;

ADULT; AGED; ANTINEOPLASTIC AGENTS, ALKYLATING; BRAIN NEOPLASMS; DACARBAZINE; DOSE FRACTIONATION; DRUG ADMINISTRATION SCHEDULE; FEMALE; GLIOBLASTOMA; HUMANS; MALE; MAXIMUM TOLERATED DOSE; MIDDLE AGED; PROSPECTIVE STUDIES; RADIOTHERAPY, INTENSITY-MODULATED; TUMOR BURDEN;

EID: 77950578979     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.04.064     Document Type: Article

References (21)

1. Fuller C.D., Choi M., Forthuber B., et al. Standard fractionation intensity modulated radiation therapy (IMRT) of primary and recurrent glioblastoma multiforme. Radiat Oncol 2 (2007) 26
2. Chang C.H., Horton J., Schoenfeld D., et al. Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A joint Radiation Therapy Oncology Group and Eastern Cooperative Oncology Group study. Cancer 52 (1983) 997-1007
3. Nakagawa K., Aoki Y., Fujimaki T., et al. High-dose conformal radiotherapy influenced the pattern of failure but did not improve survival in glioblastoma multiforme. Int J Radiat Oncol Biol Phys 40 (1998) 1141-1149
4. Kristiansen K., Hagen S., Kollevold T., et al. Combined modality therapy of operated astrocytomas Grade III and IV. Confirmation of the value of postoperative irradiation and lack of potentiation of bleomycin on survival time: a prospective multicenter trial of the Scandinavian Glioblastoma Study Group. Cancer 47 (1981) 649-652
5. Stupp R., Mason W.P., van den Bent M.J., et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352 (2005) 987-996
6. Hermanto U., Frija E.K., Lii M.J., et al. Intensity-modulated radiotherapy (IMRT) and conventional three-dimensional conformal radiotherapy for high-grade gliomas: Does IMRT increase the integral dose to normal brain?. Int J Radiat Oncol Biol Phys 67 (2007) 1135-1144
7. Chan M.F., Schupak K., Burman C., et al. Comparison of intensity-modulated radiotherapy with three-dimensional conformal radiation therapy planning for glioblastoma multiforme. Med Dosim 28 (2003) 261-265
8. Floyd N.S., Woo S.Y., Teh B.S., et al. Hypofractionated intensity-modulated radiotherapy for primary glioblastoma multiforme. Int J Radiat Oncol Biol Phys 58 (2004) 721-726
9. Iuchi T., Hatano K., Narita Y., et al. Hypofractionated high-dose irradiation for the treatment of malignant astrocytomas using simultaneous integrated boost technique by IMRT. Int J Radiat Oncol Biol Phys 64 (2006) 1317-1324
10. Narayana A., Yamada J., Berry S., et al. Intensity-modulated radiotherapy in high-grade gliomas: Clinical and dosimetric results. Int J Radiat Oncol Biol Phys 64 (2006) 892-897
11. Sultanem K., Patrocinio H., Lambert C., et al. The use of hypofractionated intensity-modulated irradiation in the treatment of glioblastoma multiforme: Preliminary results of a prospective trial. Int J Radiat Oncol Biol Phys 58 (2004) 247-252
12. Suzuki M., Nakamatsu K., Kanamori S., et al. Feasibility study of the simultaneous integrated boost (SIB) method for malignant gliomas using intensity-modulated radiotherapy (IMRT). Jpn J Clin Oncol 33 (2003) 271-277
13. Thilmann C., Zabel A., Grosser K.H., et al. Intensity-modulated radiotherapy with an integrated boost to the macroscopic tumor volume in the treatment of high-grade gliomas. Int J Cancer 96 (2001) 341-349
14. Cox J.D., Stetz J., and Pajak T.F. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 31 (1995) 1341-1346
15. Withers H.R. Biological basis of radiation therapy. In: Perez C.A., and Brady L.W. (Eds). Principles and practice of radiation oncology (1992), Lippincott, Philadelphia 64-69
16. Kaplan F.L., and Meier P. Nonparametric estimation from incomplete observations. Am J Stat Assoc 53 (1958) 457-481
17. Al-Ghazi M., Kwon R., Kuo J., et al. The University of California, Irvine experience with tomotherapy using the Peacock system. Med Dosim 26 (2001) 17-27
18. Chan J.L., Lee S.W., Fraass B.A., et al. Survival and failure patterns of high-grade gliomas after three-dimensional conformal radiotherapy. J Clin Oncol 20 (2002) 1635-1642
19. Hulshof M.C., Shimmel E.C., Andries Bosch D., and Gonzalez Gonzalez D. Hypofractionation in glioblastoma multiforme. Radiother Oncol 54 (2000) 143-148
20. Panet-Raymond V., Souhami L., Roberge D., et al. Accelerated hypofractionated intensity-modulated radiotherapy with concurrent and adjuvant temozolomide for patients with glioblastoma multiforme: A safety and efficacy analysis. Int J Radiat Oncol Biol Phys 73 (2009) 473-478
21. Curran Jr. W.J., Scott C.B., Horton J., et al. Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials. J Natl Cancer Inst 85 (1993) 704-710