ADVANCED CANCER;
CANCER CHEMOTHERAPY;
CANCER PATIENT;
CANCER RESISTANCE;
CANCER SURVIVAL;
COLORECTAL CANCER;
DRUG EFFICACY;
DRUG TARGETING;
ENZYME ACTIVITY;
GENE SILENCING;
HUMAN;
NONHUMAN;
NOTE;
PRIORITY JOURNAL;
PROTEIN FUNCTION;
TREATMENT RESPONSE;
ADAM PROTEINS;
COLORECTAL NEOPLASMS;
DRUG DELIVERY SYSTEMS;
DRUG RESISTANCE, NEOPLASM;
HUMANS;
RECEPTOR, EPIDERMAL GROWTH FACTOR;
TUMOR MARKERS, BIOLOGICAL;
Chemotherapy-induced activation of ADAM-17: A novel mechanism of drug resistance in colorectal cancer
Kyula JN, Van Schaeybroeck S, Doherty J, Fenning JS, Longley DB, Johnston PG. Chemotherapy-induced activation of ADAM-17: a novel mechanism of drug resistance in colorectal cancer. Clin Cancer Res 2010;16:3378-89.
Targeting the EGFR, VEGFR, and PDGFR on colon cancer cells and stromal cells is required for therapy
Kuwai T, Nakamura T, Sasaki T, et al. Targeting the EGFR, VEGFR, and PDGFR on colon cancer cells and stromal cells is required for therapy. Clin Exp Metastasis 2008;25:477-89.
The discovery of receptor tyrosine kinases: Targets for cancer therapy
Gschwind A, Fischer OM, Ullrich A. The discovery of receptor tyrosine kinases: targets for cancer therapy. Nat Rev Cancer 2004;4:361-70. (Pubitemid 38579482)
Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha
Moss ML, Jin SL, Milla ME, et al. Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha. Nature 1997;385:733-6.
Oxidative and osmotic stress signaling in tumor cells is mediated by ADAM proteases and heparin-binding epidermal growth factor
Fischer OM, Hart S, Gschwind A, Prenzel N, Ullrich A. Oxidative and osmotic stress signaling in tumor cells is mediated by ADAM proteases and heparin-binding epidermal growth factor. Mol Cell Biol 2004;24:5172-83.
TACE/ADAM-17: A component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer
Merchant NB, Voskresensky I, Rogers CM, et al. TACE/ADAM-17: a component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer. Clin Cancer Res 2008;14:1182-91.
Implications for KRAS status and EGFR-targeted therapies in metastatic CRC
Normanno N, Tejpar S, Morgillo F, De Luca A, Van Cutsem E, Ciardiello F. Implications for KRAS status and EGFR-targeted therapies in metastatic CRC. Nat Rev Clin Oncol 2009;6:519-27.