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Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 12, 2010, Pages 3561-3564

MMP-13 selective isonipecotamide α-sulfone hydroxamates

(10) Kolodziej, Stephen A a Hockerman, Susan L a Decrescenzo, Gary A a McDonald, Joseph J a Mischke, Debbie A a Munie, Grace E a Fletcher, Theresa R a Stehle, Nathan a Swearingen, Craig a Becker, Daniel P a,b

a PFIZER INC (United States)

b LOYOLA UNIVERSITY CHICAGO (United States)

Author keywords

Hydroxamate; Matrix metalloproteinase inhibitor; Metalloenzyme; MMP inhibitor; MMP 13 selective

Indexed keywords

COLLAGENASE 3; HYDROXAMIC ACID DERIVATIVE; ISONIPECOTAMIDE ALPHA SULFONE HYDROXAMATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL BOND; CHEMICAL STRUCTURE; DRUG HALF LIFE; IC 50; MOLECULAR WEIGHT; NONHUMAN; RAT; SYNTHESIS;

ADMINISTRATION, ORAL; AMIDES; ANIMALS; HYDROXAMIC ACIDS; INHIBITORY CONCENTRATION 50; MATRIX METALLOPROTEINASE 13; RATS; SMALL MOLECULE LIBRARIES; SOLUBILITY; SUBSTRATE SPECIFICITY; SULFONES;

EID: 77954219818 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2010.04.111 Document Type: Article

Times cited : (28)

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