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Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 12, 2010, Pages 3742-3745

Synthesis and evaluation of azabicyclo[3.2.1]octane derivatives as potent mixed vasopressin antagonists

(10) Crombie, Aimee L a Antrilli, Thomas M b Campbell, Brandon A b Crandall, David L b Failli, Amedeo A c He, Yanan b Kern, Jeffrey C a Moore, William J a Nogle, Lisa M b Trybulski, Eugene J a

a PFIZER INC (United States)

b PGRD (United States)

c Chemical Sciences (United States)

Author keywords

Azabicyclo 3.2.1 octane; V1a receptor antagonist; V2 receptor antagonist; Vasopressin

Indexed keywords

AMIDE; AZABICYCLO[3.2.1]OCTANE DERIVATIVE; CONIVAPTAN; OCTANE; UNCLASSIFIED DRUG; VASOPRESSIN ANTAGONIST;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN; RAT; RECEPTOR BINDING;

ANIMALS; ARGININE VASOPRESSIN; AZA COMPOUNDS; BENZAZEPINES; BICYCLO COMPOUNDS; HUMANS; MOLECULAR STRUCTURE; OCTANES; RECEPTORS, VASOPRESSIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77954219094 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2010.04.068 Document Type: Article

Times cited : (20)

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