Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious γ-secretase inhibitors (Part II)

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 12, 2010, Pages 3502-3506

  Ye, Xiaocong M ^a   Konradi, Andrei W ^a   Smith, Jenifer ^a   Aubele, Danielle L ^a   Garofalo, Albert W ^a   Marugg, Jennifer ^a   Neitzel, Marty L ^a   Semko, Chris M ^a   Sham, Hing L ^a   Sun, Minghua ^a   Truong, Anh P ^a   Wu, Jing ^a   Zhang, Hongbin ^a   Goldbach, Erich ^a   Sauer, John Michael ^a   Brigham, Elizabeth F ^a   Bova, Michael ^a   Basi, Guriqbal S ^a  

^a ELAN PHARMACEUTICALS   (United States)

Author keywords

Secretase; Secretase inhibitor; Alzheimer's disease; Amyloid precursor protein

Indexed keywords

GAMMA SECRETASE INHIBITOR; PIPERIDINE DERIVATIVE; SULFONAMIDE;

ANIMAL EXPERIMENT; ARTICLE; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; DRUG STABILITY; DRUG STRUCTURE; IN VIVO STUDY; MOUSE; NONHUMAN; SINGLE DRUG DOSE;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; DRUG DISCOVERY; DRUG STABILITY; MICROSOMES, LIVER; PIPERIDINES; PROTEASE INHIBITORS; SULFONAMIDES;

EID: 77954215194     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.04.148     Document Type: Article

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