Discovery of sulfonamide-pyrazole γ-secretase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 7, 2010, Pages 2148-2150

  Mattson, Matthew N ^a   Neitzel, Martin L ^a   Quincy, David A ^a   Semko, Christopher M ^a   Garofalo, Albert W ^a   Keim, Pamela S ^a   Konradi, Andrei W ^a   Pleiss, Michael A ^a   Sham, Hing L ^a   Brigham, Elizabeth F ^a   Goldbach, Erich G ^a   Zhang, Hongbin ^a   Sauer, John Michael ^a   Basi, Guriqbal S ^a  

^a ELAN PHARMACEUTICALS   (United States)

Author keywords

secretase inhibitor; Alzheimer's disease; Sulfonamide

Indexed keywords

2 AMINOTHIAZOLE; 4 CHLOROBENZENESULFONAMIDE; BENZENESULFONAMIDE DERIVATIVE; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; ISOXAZOLE; PYRAZOLE; PYRAZOLE DERIVATIVE; SULFONAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN; DRUG CLEARANCE; DRUG METABOLISM; DRUG PENETRATION; DRUG POTENCY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PHARMACOLOGICAL PARAMETERS; PHARMACOPHORE; RAT;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CRYSTALLOGRAPHY, X-RAY; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 77949490430     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.02.050     Document Type: Article

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