Vitreal pharmacokinetics of peptide-transporter-targeted prodrugs of ganciclovir in conscious animals

Journal of Ocular Pharmacology and Therapeutics

Volumn 26, Issue 3, 2010, Pages 265-271

  Janoria, Kumar G ^a   Boddu, Sai H S ^b   Natesan, Subramanian ^c   Mitra, Ashim K ^b  

^a Aptuit Inc   (United States)

^b UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^c ANNA UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

GANCICLOVIR; PRODRUG; ANESTHETIC AGENT; ANTIVIRUS AGENT; DIPEPTIDE;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MEAN RESIDENCE TIME; MICRODIALYSIS; NONHUMAN; RABBIT; ANIMAL; CHEMISTRY; CONSCIOUSNESS; METABOLISM; PROCEDURES; VITREOUS BODY;

ANESTHETICS; ANIMALS; ANTIVIRAL AGENTS; AREA UNDER CURVE; CONSCIOUSNESS; DIPEPTIDES; GANCICLOVIR; MALE; MICRODIALYSIS; PRODRUGS; RABBITS; VITREOUS BODY;

EID: 77954211116     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/jop.2009.0123     Document Type: Article

References (31)

1. Pepose, J.S., Holland, G.N., Nestor, M.S., Cochran, A.J., and Foos, R.Y. Acquired immune deficiency syndrome. Pathogenic mechanisms of ocular disease. Ophthalmology 4:472-484, 1985.
2. Bloom, J.N., and Palestine, A.G. The diagnosis of cytomegalovirus retinitis. Ann. Intern. Med. 12:963-969, 1988.
3. Cunningham Jr., E.T., and Margolis, T.P. Ocular manifestations of HIV infection. N. Engl. J. Med. 4:236-244, 1998.
4. Arruda, R.F., Muccioli, C., and Belfort Jr., R. [Ophthalmological findings in HIV infected patients in the post-HAART (Highly Active Anti-retroviral Therapy) era, compared to the pre-HAART era]. Rev. Assoc. Med. Bras. 2:148-152, 2004.
5. Kempen, J.H., Jabs, D.A., Wilson, L.A., Dunn, J.P., West, S.K., and Tonascia, J.A. Risk of vision loss in patients with cytomegalovirus retinitis and the acquired immunodeficiency syndrome. Arch. Ophthalmol. 4:466-476, 2003.
6. Jabs, D.A., Holbrook, J.T., Van Natta, M.L., Clark, R., Jacobson, M.A., Kempen, J.H., and Murphy, R.L. Risk factors for mortality in patients with AIDS in the era of highly active antiretroviral therapy. Ophthalmology 5:771-779, 2005.
7. Crum, N.F., and Blade, K.A. Cytomegalovirus retinitis after immune reconstitution. AIDS Read. 4:186-188, 2005.
8. Freeman, W.R., Lerner, C.W., Mines, J.A., Lash, R.S., Nadel, A.J., Starr, M.B., and Tapper, M.L. A prospective study of the ophthalmologic findings in the acquired immune deficiency syndrome. Am. J. Ophthalmol. 2:133-142, 1984.
9. Bodaghi, B., Slobbe-van Drunen, M.E., Topilko, A., Perret, E., Vossen, R.C., van Dam-Mieras, M.C., Zipeto, D., Virelizier, J.L., LeHoang, P., Bruggeman, C.A., and Michelson, S. Entry of human cytomegalovirus into retinal pigment epithelial and endothelial cells by endocytosis. Invest. Ophthalmol. Vis. Sci. 11:2598-2607, 1999.
10. Bodaghi, B., and Michelson, S. Cytomegalovirus: virological facts for clinicians. Ocul. Immunol. Inflamm. 7:133-137, 1999.
11. Burd, E.M., Pulido, J.S., Puro, D.G., and O'Brien, W.J. Replication of human cytomegalovirus in human retinal glial cells. Invest. Ophthalmol. Vis. Sci. 10:1957-1966, 1996.
12. Rao, N.A., Zhang, J., and Ishimoto, S. Role of retinal vascular endothelial cells in development of CMV retinitis. Trans. Am. Ophthalmol. Soc. 23:124-126, 1998.
13. Magone, M.T., Nussenblatt, R.B., and Whitcup, S.M. Elevation of laser flare photometry in patients with cytomegalovirus retinitis and AIDS. Am. J. Ophthalmol. 2:190-198, 1997.
14. Nussenblatt, R.B., and Lane, H.C. Human immunodeficiency virus disease: changing patterns of intraocular inflammation. Am. J. Ophthalmol. 3:374-382, 1998.
15. Macha, S., Duvvuri, S., and Mitra, A.K. Ocular disposition of novel lipophilic diester prodrugs of ganciclovir following intravitreal administration using microdialysis. Curr. Eye Res. 2:77-84, 2004.
16. Majumdar, S., Kansara, V., and Mitra, A.K. Vitreal pharmacokinetics of dipeptide monoester prodrugs of ganciclovir. J. Ocul. Pharmacol. Ther. 4:231-241, 2006.
17. Dias, C.S., and Mitra, A.K. Posterior segment ocular pharmacokinetics using microdialysis in a conscious rabbit model. Invest. Ophthalmol. Vis. Sci. 1:300-305, 2003.
18. Stempels, N., Tassignon, M.J., and Sarre, S. A removable ocular microdialysis system for measuring vitreous biogenic amines. Graefes Arch. Clin. Exp. Ophthalmol. 11:651-655, 1993.
19. Hughes, P.M., Krishnamoorthy, R., and Mitra, A.K. Vitreous disposition of two acycloguanosine antivirals in the albino and pigmented rabbit models: a novel ocular microdialysis technique. J. Ocul. Pharmacol. Ther. 2:209-224, 1996.
20. Macha, S., and Mitra, A.K. Ocular pharmacokinetics in rabbits using a novel dual probe microdialysis technique. Exp. Eye Res. 3:289-299, 2001.
21. Waga, J., and Ehinger, B. Intravitreal concentrations of some drugs administered with microdialysis. Acta Ophthalmol. Scand. 1:36-40, 1997.
22. Gunnarson, G., Jakobsson, A.K., Hamberger, A., and Sjostrand, J. Free amino acids in the pre-retinal vitreous space. Effect of high potassium and nipecotic acid. Exp. Eye Res. 2:235-244, 1987.
23. Anand, B.S., Atluri, H., and Mitra, A.K. Validation of an ocular microdialysis technique in rabbits with permanently implanted vitreous probes: systemic and intravitreal pharmacokinetics of fluorescein. Int. J. Pharm. 281:79-88, 2004.
24. Waga, J., Nilsson-Ehle, I., Ljungberg, B., Skarin, A., Stahle, L., and Ehinger, B. Microdialysis for pharmacokinetic studies of ceftazidime in rabbit vitreous. J. Ocul. Pharmacol. Ther. 5:455-463, 1999.
25. Waga, J., Ohta, A., and Ehinger, B. Intraocular microdialysis with permanently implanted probes in rabbit. Acta Ophthalmol. (Copenh). 69:618-624, 1991.
26. Rittenhouse, K.D., Peiffer Jr., R.L., and Pollack, G.M. Microdialysis evaluation of the ocular pharmacokinetics of propranolol in the conscious rabbit. Pharm. Res. 5:736-742, 1999.
27. Rittenhouse, K.D., Peiffer Jr., R.L., and Pollack, G.M. Evaluation of microdialysis sampling of aqueous humor for in vivo models of ocular absorption and disposition. J. Pharm. Biomed. Anal. 6:951-959, 1998.
28. Lipman, N.S., Phillips, P.A., and Newcomer, C.E. Reversal of ketamine/xylazine anesthesia in the rabbit with yohimbine. Lab. Anim. Sci. 4:474-477, 1987.
29. Jia, L., Cepurna, W.O., Johnson, E.C., and Morrison, J.C. Effect of general anesthetics on IOP in rats with experimental aqueous outflow obstruction. Invest. Ophthalmol. Vis. Sci. 41:3415-3419, 2000.
30. Majumdar, S., Nashed, Y.E., Patel, K., Jain, R., Itahashi, M., Neumann, D.M., Hill, J.M., and Mitra, A.K. Dipeptide monoester ganciclovir prodrugs for treating HSV-1-induced corneal epithelial and stromal keratitis: in vitro and in vivo evaluations. J. Ocul. Pharmacol. Ther. 6:463-474, 2005.
31. Xu, J., Heys, J.J., Barocas, V.H., and Randolph, T.W. Permeability and diffusion in vitreous humor: implications for drug delivery. Pharm. Res. 6:664-669, 2000.