Posterior segment ocular pharmacokinetics using microdialysis in a conscious rabbit model

Investigative Ophthalmology and Visual Science

Volumn 44, Issue 1, 2003, Pages 300-305

  Dias, Clapton S ^a   Mitra, Ashim K ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EYE PROTEIN; GANCICLOVIR; KETAMINE; MANNITOL; POLYACRYLONITRILE; TRITIUM; TROPICAMIDE; XYLAZINE;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; MALE; MICRODIALYSIS; NONHUMAN; POSTERIOR EYE CHAMBER; PRIORITY JOURNAL; PROTEIN SECRETION; RABBIT; RETINITIS; VITREOUS BODY;

ANESTHETICS, DISSOCIATIVE; ANIMALS; ANTIVIRAL AGENTS; BIOLOGICAL AVAILABILITY; CATHETERS, INDWELLING; CONSCIOUSNESS; GANCICLOVIR; HALF-LIFE; KETAMINE; MALE; MICRODIALYSIS; MODELS, ANIMAL; RABBITS; VITREOUS BODY;

EID: 0037247606     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.02-0566     Document Type: Article

References (20)

1. Gunnarson G, Jakobsson AK, Hamberger A, Sjostrand J. Free amino acids in the pre-retinal vitreous space: effect of high potassium and nipecotic acid. Exp Eye Res. 1987;44:235-244.
2. Waga J, Ehinger B. Intravitreal concentrations of some drugs administered with microdialysis. Acta Ophthalmol Scand. 1997;75:36-40.
3. Stempels N, Tassignon MJ, Sarre S. A removable ocular microdialysis system for measuring vitreous biogenic amines. Graefes Arch Clin Exp Ophthalmol. 1993;231:651-655.
4. Hughes PM, Krishnamoorthy R, Mitra AK. Vitreous disposition of two acycloguanosine antivirals in the albino and pigmented rabbit models: a novel ocular microdialysis technique. J Ocul Pharmacol Ther. 1996;12:209-224.
5. Macha S, Mitra AK. Ocular pharmacokinetics in rabbits using a novel dual probe microdialysis technique. Exp Eye Res. 2001;72:289-299.
6. Waga J, Ohta A, Ehinger B. Intraocular microdialysis with permanently implanted probes in rabbit. Acta Ophthalmol (Copenh). 1991;69:618-624.
7. Waga J, Nilsson-Ehle I, Ljungberg B, et al. Microdialysis for pharmacokinetic studies of ceftazidime in rabbit vitreous. J Ocul Pharmacol Ther. 1999;15:455-463.
8. Rittenhouse KD, Peiffer RL Jr, Pollack GM. Evaluation of microdialysis sampling of aqueous humor for in vivo models of ocular absorption and disposition. J Pharm Biomed Anal. 1998;16:951-959.
9. Rittenhouse KD, Peiffer RL Jr, Pollack GM. Assessment of ascorbate ocular disposition in the conscious rabbit: an approach using the microdialysis technique. Curr Eye Res. 2000;20:351-360.
10. Sanford TD, Colby ED. Effect of xylazine and ketamine on blood pressure, heart rate and respiratory rate in rabbits. Lab Anim Sci. 1980;30:519-523.
11. Lipman NS, Phillips PA, Newcomer CE. Reversal of ketamine/xylazine anesthesia in the rabbit with yohimbine. Lab Anim Sci. 1987;37:474-477.
12. Burke JA, Potter DE. The ocular effects of xylazine in rabbits, cats, and monkeys. J Ocul Pharmacol. 1986;2:9-21.
13. Trim CM, Colbern GT, Martin CL. Effect of xylazine and ketamine on intraocular pressure in horses. Vet Rec. 1985;117:442-443.
14. Jia L, Cepurna WO, Johnson EC, Morrison JC. Effect of general anesthetics on IOP in rats with experimental aqueous outflow obstruction. Invest Ophthalmol Vis Sci. 2000;41:3415-3419.
15. Heery S, Hollows F. High-dose intravitreal gancyclovir for cytomegaloviral (CMV) retinitis. Aust NZJ Ophthalmol. 1989;17:405-408.
16. Hoffman VF, Skiest DJ. Therapeutic developments in cytomegalo-virus retinitis. Expert Opin Invest Drugs. 2000;9:207-220.
17. Rittenhouse KD, Peiffer RL Jr, Pollack GM. Microdialysis evaluation of the ocular pharmacokinetics of propranolol in the conscious rabbit. Pharm Res. 1999;16:736-742.
18. Xu J, Heys JJ, Barocas VH, Randolph TW. Permeability and diffusion in vitreous humor: implications for drug delivery. Pharm Res. 2000;17:664-669.
19. Lopez-Cortes LF, Pastor-Ramos MT, Ruiz-Valderas R, et al. Intravitreal pharmacokinetics and retinal concentrations of ganciclovir and foscarnet after intravitreal administration in rabbits. Invest Ophthalmol Vis Sci. 2001;42:1024-1028.
20. Macha S, Mitra AK. Ocular disposition of ganciclovir and its monoester prodrugs following intravitreal administration using microdialysis. Drug Metab Dispos. 2002;30:670-675.