Nociceptin inhibits uterine contractions in term-pregnant rats by signaling through multiple pathways

Biology of Reproduction

Volumn 83, Issue 1, 2010, Pages 36-41

  Klukovits, A ^a   Tekes, K ^b   Gunduz Cinar O ^c   Benyhe, S ^c   Borsodi, A ^c   Deak B H ^a   Hajagos Toth J ^a   Verli, J ^a   Falkay, G ^a   Gáspár, Róbert ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Cyclic adenosine monophosphate; Neuropeptides; Pregnancy; Signal transduction; Uterus

Indexed keywords

CALCIUM ACTIVATED POTASSIUM CHANNEL; CYCLIC AMP; FORSKOLIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATE; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; ISOBUTYLMETHYLXANTHINE; NALOXONE; NOCICEPTIN; NOCICEPTIN RECEPTOR; OXYTOCIN; PAXILLIN; PERTUSSIS TOXIN; POTASSIUM CHANNEL; POTASSIUM CHLORIDE; RADIOLIGAND; SULFUR 35; TETRYLAMMONIUM; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); KCNMA1 PROTEIN, RAT; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNIT; OPIATE PEPTIDE; OPIATE RECEPTOR; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; SULFUR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME IMMUNOASSAY; FEMALE; LIGAND BINDING; MYOMETRIUM; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RAT; SIGNAL TRANSDUCTION; TERM BIRTH; UTERUS CONTRACTION; ANIMAL; IN VITRO STUDY; METABOLISM; RADIOASSAY; SPRAGUE DAWLEY RAT; UTERUS;

RATTUS;

ANIMALS; CYCLIC AMP; FEMALE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); IN VITRO TECHNIQUES; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNITS; OPIOID PEPTIDES; PREGNANCY; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID; SIGNAL TRANSDUCTION; SULFUR RADIOISOTOPES; UTERINE CONTRACTION; UTERUS;

EID: 77954208850     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.109.082222     Document Type: Article

References (41)

1. Meunier JC, Mollereau C, Toll L, Suaudeau C, Moisand C, Alvinerie P, Butour JL, Guillemot JC, Ferrara P, Monsarrat B. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature 1995; 377:532-535.
2. Reinscheid RK, Nothacker HP, Bourson A, Ardati A, Henningsen RA, Bunzow JR, Grandy DK, Langen H, Monsma FJ Jr, Civelli O. Orphanin FQ: a neuropeptide that activates an opioid-like G protein-coupled receptor. Science 1995; 270:792-794.
3. Lachowicz JE, Shen Y, Monsma FJ Jr, Sibley DR. Molecular cloning of a novel G protein-coupled receptor related to the opiate receptor family. J Neurochem 1995; 64:34-40.
4. Mogil JS, Pasternak GW. The molecular and behavioral pharmacology of the orphanin FQ/nociceptin peptide and receptor family. Pharmacol Rev 2001; 53:381-415.
5. An XF, Chen HP, Ma SL, Feng Y, Hao JW, Chen BY. Involvement of nociceptin/orphanin FQ in release of hypothalamic GnRH mediated by ORL1 receptor in ovariectomized rats. Acta Pharmacol Sin 2005; 26:1039-1044.
6. Flau K, Redmer A, Liedtke S, Kathmann M, Schlicker E. Inhibition of striatal and retinal dopamine release via nociceptin/orphanin FQ receptors. Br J Pharmacol 2002; 137:1355-1361. (Pubitemid 36071754)
7. Lippl F, Schusdziarra V, Huepgens K, Allescher HD. Inhibitory effect of nociceptin on somatostatin secretion of the isolated perfused rat stomach. Regul Pept 2002; 107:37-42. (Pubitemid 34876443)
8. Basso M, Risse PA, Naline E, Calo G, Guerrini R, Regoli D, Advenier C. Nociceptin/orphanin FQ inhibits electrically induced contractions of the human bronchus via NOP receptor activation. Peptides 2005; 26:1492-1496. (Pubitemid 41021486)
9. Gündüz O, Rizzi A, Baldisserotto A, Guerrini R, Spagnolo B, Gavioli EC, Kocsis L, Magyar A, Benyhe S, Borsodi A, Calò G. In vitro and in vivo pharmacological characterization of the nociceptin/orphanin FQ receptor ligand Ac-RYYRIK-ol. Eur J Pharmacol 2006; 539:39-48.
10. Williams JP, Thompson JP, McDonald J, Barnes TA, Cote T, Rowbotham DJ, Lambert DG. Human peripheral blood mononuclear cells express nociceptin/orphanin FQ, but not mu, delta, or kappa opioid receptors. Anesth Analg 2007; 105:998-1005. (Pubitemid 47479313)
11. Burmeister MA, Ansonoff MA, Pintar JE, Kapusta DR. Nociceptin/orphanin FQ (N/OFQ)-evoked bradycardia, hypotension, and diuresis are absent in N/OFQ peptide (NOP) receptor knockout mice. J Pharmacol Exp Ther 2008; 326:897-904.
12. Peiser C, Undem BJ, Fischer A. Nociceptin effects in the airways. Peptides 2000; 21:995-998.
13. Broccardo M, Agostini S, Petrella C, Guerrini R, Improta G. Central and peripheral role of the nociceptin/orphanin FQ system on normal and disturbed colonic motor function and fecal pellet output in the rat. Neurogastroenterol Motil 2008; 20:939-948. (Pubitemid 352019713)
14. Gimpl G, Fahrenholz F. The oxytocin receptor system: structure, function, and regulation. Physiol Rev 2001; 81:629-683. (Pubitemid 32267075)
15. Shew RL, Papka RE, McNeill DL. Galanin and calcitonin gene-related peptide immunoreactivity in nerves of the rat uterus: localization, colocalization, and effects on uterine contractility. Peptides 1992; 13:273-279.
16. Collins JJ, Usip S, McCarson KE, Papka RE. Sensory nerves and neuropeptides in uterine cervical ripening. Peptides 2002; 23:167-183. (Pubitemid 34113777)
17. Pennefather JN, Reynoldson NA, Handberg GM. Inhibition of rat uterine contractions by rat and human CGRP. Peptides 1990; 11:903-906.
18. Shew RL, Papka RE, McNeill DL. Substance P and calcitonin gene-related peptide immunoreactivity in nerves of the rat uterus: localization, colocalization and effects on uterine contractility. Peptides 1991; 12:593-600.
19. Klukovits A, Gáspár R, Sántha P, Jancsó G, Falkay G. Role of capsaicin-sensitive nerve fibers in uterine contractility in the rat. Biol Reprod 2004;70:184-190. (Pubitemid 38063566)
20. Tekes K, Hantos M, Gyenge M, Bizderi B, Kecskeméti V. Diabetes and endogenous orphanin FQ/nociceptin levels in rat CSF and plasma. Int J Diab Metabol 2005; 513:147-153. (Pubitemid 44783786)
21. Ligeti M, Gündüz O, Magyar A, Kató E, Rónai AZ, Vita C, Varga I, Hudecz F, Tóth G, Borsodi A, Benyhe S. Synthesis and biological studies of nociceptin derivatives containing the DTPA chelating group for further labeling with therapeutic radionuclides. Peptides 2005; 26:1159-1166. (Pubitemid 40798072)
22. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72:248-254.
23. Sim LJ, Selley DE, Childers SR. In vitro autoradiography of receptor-activated G proteins in rat brain by agonist-stimulated guanylyl 5′-[gamma-[35S]thio]-triphosphate binding. Proc Natl Acad Sci U S A 1995; 92:7242-7246.
24. Traynor JR, Nahorski SR. Modulation by mu-opioid agonists of guanosine-5′-O-(3-[35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells. Mol Pharmacol 1995; 47:848-854.
25. Gaspar R, Gal A, Galik M, Ducza E, Minorics R, Kolarovszki-Sipiczki Z, Klukovits A, Falkay G. Different roles of alpha2-adrenoceptor subtypes in nonpregnant and late-pregnant uterine contractility in vitro in the rat. Neurochem Int 2007; 51:311-318. (Pubitemid 47374324)
26. Foradori CD, Amstalden M, Coolen LM, Singh SR, McManus CJ, Handa RJ, Goodman RL, Lehman MN. Orphanin FQ: evidence for a role in the control of the reproductive neuroendocrine system. Endocrinology 2007; 148:4993-5001. (Pubitemid 47481534)
27. Sinchak K, Romeo HE, Micevych PE. Site-specific estrogen and progestin regulation of orphanin FQ/nociceptin and nociceptin opioid receptor mRNA expression in the female rat limbic hypothalamic system. J Comp Neurol 2006; 496:252-268.
28. Vértes Z, Környei JL, Kovács S, Vértes M. Opioids regulate cell proliferation in the developing rat uterus: effects during the period of sexual maturation. J Steroid Biochem Mol Biol 1996; 59:173-178. (Pubitemid 27036269)
29. Wittert G, Hope P, Pyle D. Tissue distribution of opioid receptor gene expression in the rat. Biochem Biophys Res Commun 1996; 218:877-881. (Pubitemid 26050757)
30. Arletti R, Benelli A, Bertolini A. Influence of oxytocin on nociception and morphine antinociception. Neuropeptides 1993; 24:125-129. (Pubitemid 23090206)
31. Ge Y, Lundeberg T, Yu LC. Blockade effect of mu and kappa opioid antagonists on the anti-nociception induced by intra-periaqueductal grey injection of oxytocin in rats. Brain Res 2002; 927:204-207. (Pubitemid 34124127)
32. Agostini S, Eutamene H, Broccardo M, Improta G, Petrella C, Theodorou V, Bueno L. Peripheral anti-nociceptive effect of nociceptin/orphanin FQ in inflammation and stress-induced colonic hyperalgesia in rats. Pain 2009; 141:292-299.
33. Leo CP, Pisarska MD, Hsueh AJW. DNA array analysis of changes in preovulatory gene expression in the rat ovary. Biol Reprod 2001; 65:269-276. (Pubitemid 32574809)
34. Clarke S, Chen Z, Hsu MS, Hill RG, Pintar JE, Kitchen I. Nociceptin/orphanin FQ knockout mice display up-regulation of the opioid receptor-like 1 receptor and alterations in opioid receptor expression in the brain. Neuroscience 2003; 117:157-168. (Pubitemid 36246513)
35. New DC, Wong YH. The ORL1 receptor: molecular pharmacology and signaling mechanisms. Neurosignals 2002; 11:197-212. (Pubitemid 37494399)
36. Abrão KC, Francisco RP, Miyadahira S, Cicarelli DD, Zugaib M. Elevation of uterine basal tone and fetal heart rate abnormalities after labor analgesia: a randomized controlled trial. Obstet Gynecol 2009; 113:41-47.
37. Hawes BE, Graziano MP, Lambert DG. Cellular actions of nociceptin: transduction mechanisms. Peptides 2000; 21:961-967.
38. Lefkowitz RJ, Pierce KL, Luttrell LM. Dancing with different partners: protein kinase A phosphorylation of seven membrane-spanning receptors regulates their G protein-coupling specificity. Mol Pharmacol 2002; 62:971-974.
39. Knollman PE, Conn PM. Multiple G proteins compete for binding with the human gonadotropin releasing hormone receptor. Arch Biochem Biophys 2008; 477:92-97.
40. Chanrachakul B, Pipkin FB, Khan RN. Contribution of coupling between human myometrial beta2-adrenoreceptor and the BK(Ca) channel to uterine quiescence. Am J Physiol Cell Physiol 2004; 287:C1747-C1752.
41. Lambert DG. The nociceptin/orphanin FQ receptor: a target with broad therapeutic potential. Nat Rev Drug Discov 2008; 7:694-710.