Investigation on the synergistic effect of a combination of chemical enhancers and modulated iontophoresis for transdermal delivery of insulin

Drug Development and Industrial Pharmacy

Volumn 36, Issue 8, 2010, Pages 993-1004

  Rastogi, Rachna ^a,b   Anand, Sneh ^a,b   Dinda, Amit K ^b   Koul, Veena ^a,b  

^a INDIAN INSTITUTE OF TECHNOLOGY DELHI   (India)

^b ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Chemical enhancers; Confocal microscopy; In vivo evaluation; Insulin; Second derivative FTIR; Transdermal iontophoresis

Indexed keywords

ALCOHOL; CINEOLE; DEOXYCHOLATE SODIUM; INSULIN; OLEIC ACID; PROPYLENE GLYCOL; ANTIDIABETIC AGENT; CYCLOHEXANOL DERIVATIVE; DEOXYCHOLIC ACID; DRUG VEHICLE; GLUCOSE BLOOD LEVEL; HYDROGEL; TERPENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DRUG DELIVERY SYSTEM; EPIDERMIS; GLUCOSE BLOOD LEVEL; IONTOPHORESIS; NONHUMAN; RAT; STRATUM CORNEUM; STREPTOZOCIN DIABETES; ADULT; ANALYSIS; ANIMAL; CHEMICALLY INDUCED; CHEMISTRY; COMPARATIVE STUDY; DEVICES; DIABETES MELLITUS, EXPERIMENTAL; DRUG FORMULATION; FEMALE; HUMAN; HYDROGEL; INTRADERMAL DRUG ADMINISTRATION; MALE; METABOLISM; PERMEABILITY; PROCEDURES; SWINE; TIME; ULTRASTRUCTURE; WISTAR RAT; YOUNG ADULT;

ADMINISTRATION, CUTANEOUS; ADULT; ANIMALS; BLOOD GLUCOSE; CYCLOHEXANOLS; DEOXYCHOLIC ACID; DIABETES MELLITUS, EXPERIMENTAL; DRUG COMPOUNDING; EPIDERMIS; FEMALE; HUMANS; HYDROGELS; HYPOGLYCEMIC AGENTS; INSULIN; IONTOPHORESIS; MALE; MONOTERPENES; OLEIC ACID; PERMEABILITY; PHARMACEUTICAL VEHICLES; RATS; RATS, WISTAR; SUS SCROFA; TIME FACTORS; YOUNG ADULT;

EID: 77954203949     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639041003682012     Document Type: Article

References (43)

1. Naik A, Kalia YN, Guy RH. (2000). Transdermal drug delivery: Overcoming the skin's barrier function. Pharm Sci Technol Today, 3:318-326
2. Barry BW. (2001). Novel mechanisms and devices to enable successful transdermal drug delivery. Eur J Pharm Sci, 14:101-114
3. Gan D, ed. (2003). Diabetic atlas. 2nd ed. Brussels, Belgium: International Diabetes Federation.
4. King H, Rewers M. (1993). Global estimates for prevalence of diabetes mellitus and impaired glucose tolerance in adults. WHO ad hoc diabetes reporting group. Diabetes Care, 16:157-177
5. Onkamo P, Vaananen S, Karvonen M, Tuomilehto J. (1999). Worldwide increase in incidence of Type I diabetes-the analysis of the data on published incidence trends. Diabetologia, 42:1395-1403
6. Flood T. (2006). Advances in insulin delivery systems and devices: Beyond the vial and syringe. Insulin, 1:99-108.
7. Khafagy ES, Morishita M, Onuki Y, Takayama K. (2007). Current challenges in non-invasive insulin delivery systems: A comparative review. Adv Drug Deliv Rev, 59:1521-1546
8. Kligman AM, Chistophers E. (1963). Preparation of isolated sheets of human stratum corneum. Arch Dermatol, 88:702-705
9. Joshi DP, Lan-Chun-Fung YL, Pritchard JG. (1979). Determination of poly (vinyl alcohol) via its complex with boric acid and iodine. Anal Chim Acta, 104:153-160
10. Banga AK, Chien YW. (1993). Hydrogel based iontotherapeutic delivery device for transdermal delivery of peptide/protein drugs. Pharm Res, 10:697-702.
11. Anand S, Koul V, Rastogi R. (2006). Modulated DC ionto-phoretic device. Ind. patent application 710/DEL/2006.
12. Scheuplein RJ. (1978). Skin as barrier. In: Jarret A, ed. The physiology and pathophysiology of skin. New York: Academic Press, 1693-1730
13. Junod A, Lambert AE, Stauffacher W, Renold AE. (1969). Diabe-togenic action of streptozotocin: Relationship of dose to metabolic response. J Clin Invest, 48:2129-2139
14. Davies DJ, Ward RJ, Heylings JR. (2004). Multi-species assessment of electrical resistance as a skin integrity marker for in vitro percutaneous absorption studies. Toxicol In Vitro, 18:351-358
15. Wester RC, Maibach HI. (1989). In vivo animal models for percutaneous absorption. In: Bronaugh RL, Maibach HI, eds. Percutaneous absorption, mechanisms-methodology-drug delivery. New York: Marcel Dekker, 221-238
16. Craane-van-Hinsberg WHM, Bax L, Flinterman NHM, Verhoef J, Junginger HE, Bodde HE. (1994). Iontophoresis of a model peptide across human skin in vitro: Effects of iontophoresis protocol, pH, and ionic strength on peptide flux and skin impedance. Pharm Res, 11:1296-1300
17. Raiman J, Koljonen M, Huikko K, Kostiainen R, Hirvonen J. (2004). Delivery and stability of LHRH and nafarelin in human skin: The effect of constant/pulsed iontophoresis. Eur J Pharm Sci, 21:371-377
18. Prasad R, Koul V, Anand S, Khar RK. (2007). Effect of DC/mDC iontophoresis and terpenes on transdermal permeation of methotrexate: In vitro study. Int J Pharm, 333:70-78
19. Nazzaro-Porro M, Passi S, Boniforti L, Belsito F. (1979). Effects of aging on fatty acids in skin surface lipids. J Invest Dermatol, 73:112-117
20. Sauermann K, Clemann S, Jaspers S, Gambichler T, Altmeyer P, Hoffmann K, et al. (2002). Age related changes of human skin investigated with histometric measurements by confocal laser scanning microscopy in vivo. Skin Res Technol, 8:52-56
21. Bhattacharyya TK, Thomas JR. (2004). Histomorphologic changes in aging skin, observations in the CBA mouse model. Arch Facial Plast Surg, 6:21-25
22. van de Weert M, Haris PI, Hennink WE, Crommelin DJA. (2001). Fourier transform infrared spectrometric analysis of protein conformation: Effect of sampling method and stress factors. Anal Biochem, 297:160-169
23. Goates CY, Knutson K. (1994). Enhanced permeation of polar compounds through human epidermis. I. Permeability and membrane structural changes in the presence of short chain alcohols. Biochim Biophys Acta, 1195:169-179
24. Bunow MR, Levin IW. (1977). Comment on the carbon-hydrogen stretching region of vibrational Raman spectra of phospholipids. Biochim Biophys Acta, 487:388-394
25. Raffy S, Teissié J. (1999). Control of lipid membrane stability by cholesterol content. Biophys J, 76:2072-2080
26. Baden HP, Bonar L, Katz E. (1968). The fibrous protein of epidermis. J Invest Dermatol, 50:301-305
27. Baden HP, Goldsmith LA, Bonar L. (1973). Conformational changes in the a-fibrous protein of epidermis. J Invest Dermatol, 60:215-218
28. Oertel RP. (1977). Protein conformational changes induced in human stratum corneum by organic sulfoxides: An infra-red spectroscopic investigation. Biopolymers, 16:2329-2345
29. Byler DM, Susi H. (1986). Examination of the secondary structure of proteins by deconvolved FTIR spectra. Biopolymers, 25:469-487
30. Bendit EG. (1966). Infrared absorption spectrum of keratin. I. Spectra of a-, b-, and supercontracted keratin. Biopolymers, 4:539-559
31. Chirgadze YN, Shestopalov BV, Venyaminov SY. (1973). Intensities and other spectral parameters of infrared amide bands of polypeptides in the beta-and random forms. Biopoly-mers, 12:1337-1351
32. Tatulian SA. (2003). ATR-FTIR: A method of choice for studying membrane proteins and lipids. Biochemistry, 42:11898-11907
33. Khurana R, Fink AL. (2000). Do parallel b-helix proteins have a unique Fourier transform infrared spectrum? Biophys J, 78:994-1000.
34. Hirsch IB. (1999). Type 1 diabetes mellitus and the use of flexible iInsulin regimens. Am Fam Physician, 60:2343-2356
35. Pillai O, Nair V, Poduri R, Panchagnula R. (1999). Transdermal iontophoresis. Part II: Peptide and protein delivery. Methods Find Exp Clin Pharmacol, 21:229-241
36. Chien YW, Siddiqui Y, Sun Y, Shi WM, Liu JC. (1987). Transder-mal iontophoretic delivery of therapeutic peptides/proteins (I) Insulin. In: Juliano RL, ed. Biological approaches in controlled delivery of drugs. Ann NY Acad Sci, 507:32-50.
37. Pillai O, Panchagnula R. (2003). Transdermal iontophoresis of insulin V. Effect of terpenes. J Control Release, 88:287-296
38. Pillai O, Panchagnula R. (2004). Transdermal iontophoresis of insulin. VI. Influence of pretreatment with fatty acids on permeation across rat skin. Skin Pharmacol Physiol, 17:289-297
39. Narishetty STK, Panchagnula R. (2004). Transdermal delivery of zidovudine: Effect of terpenes and their mechanism of action. J Control Release, 95:367-379 (Pubitemid 38340488)
40. Rastogi SK, Singh J. (2005). Effect of chemical penetration enhancer and iontophoresis on the in vitro percutaneous absorption enhancement of insulin through porcine epidermis. Pharm Dev Technol, 1:97-104.
41. Hayakawa E, Chien DS, Inagaki K, Yamamoto A, Wang W, Lee VHL. (1992). Conjunctival penetration of insulin and peptide drugs in the albino rabbit. Pharm Res, 9:769-775
42. Johansson F, Hjertberg E, Eirefelt S, Tronde A, Bengtsson UH. (2002). Mechanisms for absorption enhancement of inhaled insulin by sodium taurocholate. Eur J Pharm Sci, 17:63-71.
43. Rastogi SK, Singh J. (2002). Transepidermal transport enhancement of insulin by lipid extraction and iontophoresis. Pharm Res, 19:427-433