Quantitative Ultrasound in Osteoporosis and Bone Metabolism Pathologies

Radiologic Clinics of North America

Volumn 48, Issue 3, 2010, Pages 577-588

  Guglielmi, Giuseppe ^a,b   Scalzo, Giacomo ^b   de Terlizzi, Francesca ^c   Peh, Wilfred C G ^d,e  

^a UNIVERSITY OF FOGGIA   (Italy)

^b CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^c IGEA Srl   (Italy)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e ALEXANDRA HOSPITAL   (Singapore)

Author keywords

Amplitude dependent speed of sound; Bone quality; Broadband ultrasound attenuation; Osteoporosis; Quantitative ultrasound; Quantitative ultrasound index; Speed of sound; Stiffness

Indexed keywords

ALENDRONIC ACID; CALCITONIN; PARATHYROID HORMONE[1-34]; RALOXIFENE;

BONE DENSITY; BONE MATURATION; BONE TURNOVER; CALCANEUS; CALIBRATION; CLINICAL EFFECTIVENESS; DIAGNOSTIC ACCURACY; DUAL ENERGY X RAY ABSORPTIOMETRY; FRAGILITY FRACTURE; HIP FRACTURE; HORMONE SUBSTITUTION; HUMAN; METABOLIC BONE DISEASE; MICRO-COMPUTED TOMOGRAPHY; OSTEOPOROSIS; PHALANX; POSTMENOPAUSE; PREDICTION; PREMATURITY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; QUANTITATIVE ULTRASOUND; RADIUS; REPRODUCIBILITY; REVIEW; RISK ASSESSMENT; TIBIA; TRABECULAR BONE; ULTRASOUND; VERTEBRA FRACTURE; ECHOGRAPHY; FINGER; RADIOGRAPHY;

BONE DENSITY; CALCANEUS; FINGERS; HUMANS; OSTEOPOROSIS; RADIUS; TIBIA;

EID: 77954168705     PISSN: 00338389     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rcl.2010.02.013     Document Type: Review

References (95)

1. Nieh CF, Hans D, Fuerst, et al. Quantitative ultrasound: assessment of osteoporosis and bone status 1999, Martin Dunitz Ltd, London, p. 1-20.
2. Hans D., Njeh C.F., Genant H.K., et al. Quantitative ultrasound in bone status assessment. Rev Rhum Engl Ed 1998, 65(7-9):489-498.
3. Gluer C.C., The International Quantitative Ultrasound Consensus Group Quantitative ultrasound techniques for the assessment of osteoporosis: expert agreement on current status. J Bone Miner Res 1997, 12:1280-1288.
4. Hans D., Dargent-Molina P., Schott A.M., et al. Ultrasonographic heel measurements to predict hip fracture in elderly women: the EPIDOS prospective study. Lancet 1996, 348:511-514.
5. Bauer D.C., Gluer C.C., Cauley J.A., et al. Broadband ultrasound attenuation predict fractures strongly and independently of densitometry in older women. A prospective study. Arch Intern Med 1997, 157:629-634.
6. Khaw K.T., Reeve J., Luben R., et al. Prediction of total and hip fracture risk in men and women by quantitative ultrasound of the calcaneus: EPIC-Norfolk prospective population study. Lancet 2004, 363:197-202.
7. Guglielmi G., Njeh C.F., de Terlizzi F., et al. Phalangeal quantitative ultrasound, phalangeal morphometric variables, and vertebral fracture discrimination. Calcif Tissue Int 2003, 72(4):469-477.
8. Roben P., Barkmann R., Ullrich S., et al. Assessment of phalangeal bone loss and erosions in patients with rheumatoid arthritis by quantitative ultrasound. Ann Rheum Dis 2001, 60:670-677.
9. Birkett V., Ring E.F., Elvins D.M., et al. A comparison of bone loss in early and late rheumatoid arthritis using quantitative phalangeal ultrasound. Clin Rheumatol 2003, 22:203-207.
10. Pluskiewicz W., Nowakowska J. Bone status after long-term anticonvulsant therapy in epileptic patients: evaluation using quantitative ultrasound of calcaneus and phalanxes. Ultrasound Med Biol 1997, 23:553-558.
11. Montagnani A., Gonnelli S., Cepollaro C., et al. Quantitative ultrasound in the assessment of skeletal status in uremic patients. J Clin Densitom 1999, 2:389-395.
12. Tauchmanova L., Rossi R., Nuzzo V., et al. Bone loss determined by quantitative ultrasonometry correlates inversely with disease activity in patients with endogenous glucocorticoid excess due to adrenal mass. Eur J Endocrinol 2001, 145:241-247.
13. Luisetto G., Camozzi V., de Terlizzi F. Use of quantitative ultrasonography in differentiating osteomalacia from osteoporosis: preliminary study. J Ultrasound Med 2000, 19:251-256.
14. Camozzi V., Lumachi F., Mantero F., et al. Phalangeal quantitative ultrasound technology and dual energy X-ray densitometry in patients with primary hyperparathyroidism: influence of sex and menopausal status. Osteoporos Int 2003, 14:602-608.
15. Montagnani A., Gonnelli S., Cepollaro C., et al. Usefulness of bone quantitative ultrasound in management of osteoporosis in men. J Clin Densitom 2001, 4(3):231-237.
16. Zitzmann M., Brune M., Vieth V., et al. Monitoring bone density in hypogonadal men by quantitative phalangeal ultrasound. Bone 2002, 31:422-429.
17. Passeri G., Pini G., Troiano L., et al. Low vitamin D status, high bone turnover, and bone fractures in centenarians. J Clin Endocrinol Metab 2003, 88(11):5109-5115.
18. Baroncelli G.I., Federico G., Bertelloni S., et al. Bone quality assessment by quantitative ultrasound of proximal phalanxes of the hand in healthy subjects aged 3 - 21 years. Pediatr Res 2001, 49:713-718.
19. Baroncelli G.I., Federico G., Vignolo M., et al. The Phalangeal Quantitative Ultrasound Group. Cross-sectional reference data for phalangeal quantitative ultrasound from early childhood to young-adulthood according to gender, age, skeletal growth, and pubertal development. Bone 2006, 39:159-173.
20. Barkmann R., Rohrschenider W., Vierling M., et al. German pediatric reference data for quantitative transverse transmission ultrasound of finger phalanges. Osteoporos Int 2002, 13:55-61.
21. Baroncelli G.I., Federico G., Bertelloni S., et al. Assessment of bone quality by quantitative ultrasound of proximal phalanges of the hand and fracture rate in children and adolescents with bone and mineral disorders. Pediatr Res 2003, 54:125-136.
22. Gonnelli S., Montagnani A., Gennari L., et al. Feasibility of quantitative ultrasound measurements on the humerus of newborn infants for the assessment of the skeletal status. Osteoporos Int 2004, 15(7):541-546.
23. Rubinacci A., Moro G.E., Moehm G., et al. Quantitative ultrasound (QUS) for the assessment of osteopenia in preterm infants. Eur J Endocrinol 2003, 149(4):307-315.
24. Nemet D., Dolfin T., Wolach B., et al. Quantitative ultrasound measurements of bone speed of sound in premature infants. Eur J Pediatr 2001, 160:736-740.
25. Littner Y., Mandel D., Mimouni F.B., et al. Bone ultrasound velocity curves of newly born term and preterm infants. J Pediatr Endocrinol 2003, 16:43-47.
26. Ritschl E., Wehmeijer K., de Terlizzi F., et al. Assessment of skeletal development in preterm and term infants by quantitative ultrasound. Pediatr Res 2005, 58(2):341-346.
27. Montagnani A., Gonnelli S., Cepollaro C., et al. Graphic trace analysis of ultrasound at the phalanges may differentiate between subjects with primary hyperparathyroidism and with osteoporosis: a pilot study. Osteoporos Int 2002, 13:222-227.
28. Kleerekoper M., Nelson D.A., Flynn M.J., et al. Comparison of radiologic absorptiometry with dual energy X-ray absorptiometry and quantitative computed tomography in normal older white and black women. J Bone Miner Res 1994, 9:1745-1750.
29. Barkmann R., Kantorovich E., Singal C., et al. A new method for quantitative ultrasound measurements at multiple skeletal sites. J Clin Densitom 2000, 3:1-7.
30. Thijssen J.M., Weijers G., de Korte C.L. Objective performance testing and quality assurance of medical ultrasound equipment. Ultrasound Med Biol 2007, 33(3):460-471.
31. Paggiosi M.A., Blumsohn A., Barkmann R., et al. Effect of temperature on the longitudinal variability of quantitative ultrasound variables. J Clin Densitom 2005, 8(4):436-444.
32. Krieg M.A., Cornuz J., Hartl F., et al. Quality controls for two heel bone ultrasounds used in the Swiss Evaluation of the Methods of Measurement of Osteoporotic Fracture Risk Study. J Clin Densitom 2002, 5(4):335-341.
33. Hans D., Wacker W., Genton L., et al. Longitudinal quality control methodology for the quantitative ultrasound Achilles+ in clinical trial settings. Osteoporos Int 2002, 13(10):788-795.
34. Hans D., Alekxandrova I., Njeh C., et al. Appropriateness of internal digital phantoms for monitoring the stability of the UBIS 5000 quantitative ultrasound device in clinical trials. Osteoporos Int 2005, 16(4):435-445.
35. Glüer C.C., Eastell R., Reid D.M., et al. Association of five quantitative ultrasound devices and bone densitometry with osteoporotic vertebral fractures in a population-based sample: the OPUS Study. J Bone Miner Res 2004, 19(5):782-793.
36. Glüer C.C., Wu C.Y., Jergas M., et al. Three quantitative ultrasound parameters reflect bone structure. Calcif Tissue Int 1994, 55:46-52.
37. de Terlizzi F., Battista S., Cavani F., et al. Influence of bone tissue density and elasticity on ultrasound propagation: an in vitro study. J Bone Miner Res 2000, 15:2458-2466.
38. Cadossi R., Canè V. Pathways of transmission of ultrasound energy through the distal metaphysis of the second phalanx of pigs: an in vitro study. Osteoporos Int 1996, 6:196-206.
39. Wuster C., de Terlizzi F., Becker S., et al. Usefulness of quantitative ultrasound in evaluating structural and mechanical properties of bone: comparison of ultrasound, dual-energy X-ray absorptiometry, micro-computed tomography, and mechanical testing of human phalanges in vitro. Technol Health Care 2005, 13:1-14.
40. Barkmann R., Lüsse S., Stampa B., et al. Assessment of the geometry of human finger phalanges using quantitative ultrasound in vivo. Osteoporos Int 2000, 11:745-755.
41. McKelvie M.L., Palmer S.B. The interaction of ultrasound with cancellous bone. Phys Med Biol 1991, 36:1331-1340.
42. Barkmann R., Laugier P., Moser U., et al. A method for the estimation of femoral bone mineral density from variables of ultrasound transmission through the human femur. Bone 2007, 40(1):37-44.
43. Dencks S., Barkmann R., Padilla F., et al. Wavelet-based signal processing of in vitro ultrasonic measurements at the proximal femur. Ultrasound Med Biol 2007, 33(6):970-980.
44. Haïat G., Padilla F., Peyrin F., et al. Variation of ultrasonic parameters with microstructure and material properties of trabecular bone: a 3D model simulation. J Bone Miner Res 2007, 22:665-674.
45. Sasso M., Haïat G., Yamato Y., et al. Dependence of ultrasonic attenuation on bone mass and microstructure in bovine cortical bone. J Biomech 2008, 41(2):347-355.
46. Wüster C., Albanese C., de Aloysio D., et al. Phalangeal osteosonogrammetry study (PhOS): age related changes, diagnostic sensitivity and discrimination power. J Bone Miner Res 2000, 15(8):1603-1614.
47. Guglielmi G., Cammisa M., De Serio A., et al. Phalangeal US velocity discriminates between normal and vertebrally fractured subjects. Eur Radiol 1999, 9:1632-1637.
48. Hartl F., Tyndall A., Kraenzlin M., et al. Discriminatory ability of quantitative ultrasound parameters and bone mineral density in a population-based sample of postmenopausal women with vertebral fractures: result of the Basel Osteoporosis Study. J Bone Miner Res 2002, 17:321-330.
49. Krieg M.A., Cornuz J., Ruffieux C., et al. Burckhardt. Comparison of three bone ultrasounds for the discrimination of subjects with and without osteoporotic fractures among 7562 elderly women. J Bone Miner Res 2003, 18:1261-1266.
50. Camozzi V., De Terlizzi F., Zangari M., et al. Quantitative bone ultrasound at phalanges and calcanues in osteoporotic postmenopausal women: influence of age and measurement site. Ultrasound Med Biol 2007, 33(7):1039-1045.
51. Rosenthall L., Tenehouse A., Camijnis J. A correlative study of ultrasound calcaneal and dual-energy X-ray absorptiometry bone measurements of the lumbar spine and femur in 1000 women. Eur J Nucl Med 1995, 22:402-406.
52. Schott A.M., Weill-Engerer S., Hans D., et al. Ultrasound discriminates patients with hip fracture equally well as dual energy X-ray absorptiometry and independently of bone mineral density. J Bone Miner Res 1995, 10(2):243-249.
53. Kanis J.A., Johnell O., Oden A., et al. Ten-year probabilities of clinical vertebral fractures according to phalangeal quantitative ultrasonography. Osteoporos Int 2005, 16:1065-1070.
54. Hans D., Krieg M.A. Quantitative ultrasound for the detection and management of osteoporosis. Salud Publica Mex 2009, 51(Suppl 1):S25-S37.
55. National Osteoporosis Society. The use of quantitative ultrasound in the management of osteoporosis. Position statement of 31st January 2002.
56. Schattauer GmbH. Evidence-Based DVO Guidelines Osteoporosis in Germany; prophylaxis, diagnosis and therapy in postmenopausal women and men over 60 years. Verlag fur medizin und naturwissenschaften, 70174 Stuttgart 2006.
57. Agenzia Italiana Del Farmaco. Note AIFA 2006-2007 per l'uso appropriato dei farmaci. Supplemento ordinario alla " Gazzetta Ufficiale" n. 7 del 10 gennaio 20-Serie generale, Nota 79. 4 Gennaio 2007.
58. Montagnani A., Gonnelli S., Cepollaro C., et al. Quantitative ultrasound at the phalanges in healthy Italian men. Osteoporos Int 2000, 11:499-504.
59. Drozdzowska B., Pluskiewicz W. Skeletal status in males aged 7-80 years assessed by quantitative ultrasound at the hand phalanges. Osteoporos Int 2003, 14:295-300.
60. Ekman A., Michaelsson K., Petrén-Mallmin M., et al. Dual X-ray absorptiometry of hip, heel ultrasound, and densitometry of fingers can discriminate male patients with hip fractures from controls subjects: a comparison of four different methods. J Clin Densitom 2002, 5(1):79-85.
61. Mauloni M., Rovati L.C., Cadossi R., et al. Monitoring bone effect of transdermal hormone replacement therapy by ultrasound investigation at the phalanx. A four year follow up study. Menopause 2000, 7:402-412.
62. Ingle B.M., Machado A.B.C., Pereda C.A., et al. Monitoring alendronate and oestradiol therapy with quantitative ultrasound and bone mineral density. J Clin Densitom 2005, 8:278-286.
63. Agostinelli D., de Terlizzi F. QUS in monitoring raloxifene and estrogen-progestogens: a 4-year longitudinal study. Ultrasound Med Biol 2007, 33(8):1184-1190.
64. Gonnelli S., Martini G., Caffarelli C., et al. Teriparatide's effects on quantitative ultrasound parameters and bone density in women with established osteoporosis. Osteoporos Int 2006, 17(10):1524-1531.
65. Gonnelli S., Cepollaro C., Pondrelli C. Ultrasound parameters in osteoporotic patients treated with salmon calcitonin: a longitudinal study. Osteoporos Int 1996, 6:303-307.
66. Giorgino R., Lorusso D., Paparella P. Ultrasound bone densitometry and 2-year hormonal replacement therapy efficacy in the prevention of early postmenopausal bone loss. Osteoporos Int 1996, 6(Suppl 1):S341.
67. Halaba Z., Pluskiewicz W. The assessment of development of bone mass in children by quantitative ultrasound through the proximal phalanxes of the hand. Ultrasound Med Biol 1997, 23:1331-1335.
68. Gimeno Ballester J., Azcona San Julián C., Sierrasesúmaga Ariznabarreta L. Bone mineral density determination by osteosonography in healthy children and adolescents: normal values. An Esp Pediatr 2001, 54(6):540-546.
69. Sawyer A., Moore S., Fielding K.T., et al. Calcaneus ultrasound measurements in a convenience sample of healthy youth. J Clin Densitom 2001, 4(2):111-120.
70. Sundberg M., Gardsell P., Johnell O., et al. Comparison of quantitative ultrasound measurements in calcaneus with DXA and SXA at other skeletal sites: a population-based study on 280 children aged 11-16 years. Osteoporos Int 1998, 8:410-427.
71. Zadik Z., Price D., Diamond G. Pediatric reference curves for multi-site quantitative ultrasound and its modulators. Osteoporos Int 2003, 14:857-862.
72. Eliakim A., Nemet D., Wolach B. Quantitative ultrasound measurements of bone strength in obese children and adolescents. J Pediatr Endocrinol Metab 2001, 14:159-164.
73. Hartman C., Brik R., Tamir A., et al. Bone quantitative ultrasound and nutritional status in severely handicapped institutionalized children and adolescents. Clin Nutr 2004, 23:89-98.
74. Damilakis J., Galanakis E., Mamoulakis D., et al. Quantitative ultrasound measurements in children and adolescents with type 1 diabetes. Calcif Tissue Int 2004, 74(5):424-428.
75. Litmanovitz I., Dolfin T., Friedland O., et al. Early physical activity intervention prevents decrease of bone strength in very low birth weight infants. Pediatrics 2003, 112:15-19.
76. Pluskiewicz W., Adamczyk P., Drozdzowska B., et al. Skeletal status in children, adolescents and young adults with end-stage renal failure treated with hemo- or peritoneal dialysis. Osteoporos Int 2002, 13:353-357.
77. Pluskiewicz W., Adamczyk P., Drozdzowska B. Skeletal status in children and adolescents with chronic renal failure before onset of dialysis or on dialysis. Osteoporos Int 2003, 14:283-288.
78. Pluskiewicz W., Adamczyk P., Drozdzowska B., et al. Skeletal status in adolescents with end-stage renal failure: a longitudinal study. Osteoporos Int 2005, 16:289-295.
79. Rico H., Aguado F., Revilla M., et al. Ultrasound bone velocity and metacarpal radiogrammetry in hemodialyzed patients. Miner Electrolyte Metab 1994, 20:103-106.
80. Przedlacki J., Pluskiewicz W., Wieliczko M., et al. Quantitative ultrasound of phalanxes and dual-energy X-ray absorptiometry of forearm and hand in patients with end-stage renal failure treated with dialysis. Osteoporos Int 1999, 10:1-6.
81. Taal M.W., Cassidy M.J., Pearson D., et al. Usefulness of quantitative heel ultrasound compared with dual-energy X-ray absorptiometry in determining bone mineral density in chronic haemodialysis patients. Nephrol Dial Transplant 1999, 14:1917-1921.
82. Arici M., Ertuk H., Altun B. Bone mineral density in haemodialysis patients: a comparative study of dual-energy X-ray absorptiometry and quantitative ultrasound. Nephrol Dial Transplant 2000, 15:1847-1851.
83. Peretz A., Penaloza A., Mesquita M., et al. Quantitative ultrasound and dual X-ray absorptiometry measurements of the calcaneus in patients on maintenance hemodialysis. Bone 2000, 27:287-292.
84. Pluskiewicz W., Przedlacki J., Drozdzowska B., et al. Quantitative ultrasound at hand phalanges in adults with end-stage renal failure. Ultrasound Med Biol 2004, 30(4):455-459.
85. Guglielmi G., de Terlizzi F., Aucella F., et al. Quantitative ultrasound technique at the phalanges in discriminating between uremic and osteoporotic patients. Eur J Radiol 2006, 60(1):108-114.
86. Azcona C., Burghard E., Ruza E., et al. Reduced bone mineralization in adolescent survivors of malignant bone tumors: comparison of quantitative ultrasound and dual-energy x-ray absorptiometry. J Pediatr Hematol Oncol 2003, 25(4):297-302.
87. Pluskiewicz W., Luszczynska A., Halaba Z., et al. Skeletal status in survivors of childhood acute lymphoblastic leukemia assessed by quantitative ultrasound: a pilot cross-sectional study. Ultrasound Med Biol 2002, 28:1279-1284.
88. Pluskiewicz W., Pyrkosz A., Drozdzowska B., et al. Quantitative ultrasound of the hand phalanges in patients with genetic disorders: a pilot case-control study. Osteoporos Int 2003, 14:787-792.
89. Guglielmi G., de Terlizzi F., Torrente I., et al. Quantitative ultrasound of the hand phalanges in a cohort of monozygotic twins: influence of genetic and environmental factors. Skeletal Radiol 2005, 34(11):727-735.
90. Halaba Z., Pyrkosz A., Adamczyk P., et al. Longitudinal changes in ultrasound measurements: a parallel study in subjects with genetic disorders and healthy controls. Ultrasound Med Biol 2006, 32:409-413.
91. Filosa A., de Terlizzi F. Quantitative ultrasound (QUS): a new approach to evacuate bone status in thalassemic patients. Ital J Pediatr 2002, 28:310-318.
92. Cepollaro C., Gonnelli S., Pondrelli C., et al. Osteogenesis Imperfecta: bone turnover, bone density, and ultrasound parameters. Calcif Tissue Int 1999, 65:129-132.
93. Gonnelli S., Montagnani A., Cepollaro C., et al. Quantitative ultrasound and bone mineral density in patients with primary hyperparathyroidism before and after surgical treatment. Osteoporos Int 2000, 11:255-260.
94. Taccari E., Sensi F., Spadaro A., et al. Ultrasound measurements at the proximal phalanges in male patients with psoriatic arthritis. Osteoporos Int 2001, 12:412-416.
95. Rossini M., Viapiana O., Del Marco A., et al. Quantitative ultrasound in adults with cystic fibrosis: correlation with bone mineral density and risk of vertebral fractures. Calcif Tissue Int 2007, 80(1):44-49.